Archivio istituzionale della ricerca dell'Università degli Studi di Palermo

SPINELLO, Angelo
 Distribuzione geografica
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Continente #
NA - Nord America 2.853
EU - Europa 1.117
AS - Asia 499
AF - Africa 24
SA - Sud America 9
Continente sconosciuto - Info sul continente non disponibili 1
Totale 4.503
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Nazione #
US - Stati Uniti d'America 2.840
IT - Italia 526
SG - Singapore 228
CN - Cina 198
FI - Finlandia 144
IE - Irlanda 94
DE - Germania 93
GB - Regno Unito 54
RU - Federazione Russa 50
SE - Svezia 47
IN - India 30
FR - Francia 21
UA - Ucraina 21
CI - Costa d'Avorio 15
RO - Romania 11
ES - Italia 10
HK - Hong Kong 10
NL - Olanda 10
BE - Belgio 9
IL - Israele 9
PL - Polonia 9
CA - Canada 8
AT - Austria 5
BR - Brasile 5
KR - Corea 5
CY - Cipro 4
SA - Arabia Saudita 4
SC - Seychelles 4
CH - Svizzera 3
IR - Iran 3
JP - Giappone 3
MX - Messico 3
CL - Cile 2
CO - Colombia 2
CU - Cuba 2
CZ - Repubblica Ceca 2
LB - Libano 2
MA - Marocco 2
NG - Nigeria 2
PT - Portogallo 2
A1 - Anonimo 1
AE - Emirati Arabi Uniti 1
AL - Albania 1
BG - Bulgaria 1
DZ - Algeria 1
HR - Croazia 1
KZ - Kazakistan 1
LT - Lituania 1
MN - Mongolia 1
NO - Norvegia 1
SK - Slovacchia (Repubblica Slovacca) 1
Totale 4.503
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Città #
Fairfield 415
Ashburn 248
Chandler 244
Woodbridge 219
Singapore 194
Seattle 175
Ann Arbor 168
Houston 166
Wilmington 162
Cambridge 144
Palermo 140
Dublin 94
Medford 82
Altamura 62
Santa Clara 62
Princeton 56
Lawrence 47
Nanjing 40
San Diego 29
Dearborn 27
Rome 23
Boardman 22
New York 21
Piscataway 20
Ludwigshafen am Rhein 19
Beijing 18
Changsha 16
Milan 16
Abidjan 15
Nanchang 15
London 14
San Paolo di Civitate 14
Munich 13
Ningbo 13
Shenyang 12
Helsinki 11
Tianjin 11
Des Moines 10
Kumar 10
Sciacca 10
Brussels 9
Naples 9
Napoli 9
Trieste 9
Frankfurt 8
Jacksonville 8
Jinan 8
Kilburn 8
Aversa 7
Berlin 7
Chicago 7
Derio 7
Hebei 7
Redwood City 7
Saint Petersburg 7
Atlanta 6
Kolkata 6
Los Angeles 6
Verona 6
Hong Kong 5
Jiaxing 5
Paris 5
Phoenix 5
Taizhou 5
Tulsa 5
Cagliari 4
Central 4
Guangzhou 4
Haikou 4
Hangzhou 4
Lappeenranta 4
Moscow 4
Nicosia 4
North Kansas City 4
Polska 4
Riyadh 4
Seongnam 4
Siano 4
Toronto 4
Zhengzhou 4
Bangalore 3
Bremen 3
Campinas 3
Columbus 3
Düsseldorf 3
Erice 3
Falls Church 3
Ivry-sur-Seine 3
Little Rock 3
Monreale 3
Muenster 3
Orange 3
Partinico 3
Philadelphia 3
Taiyuan 3
Vienna 3
Washington 3
Acton 2
Amsterdam 2
Auburn Hills 2
Totale 3.365
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Nome #
Antimicrobial and Antibiofilm Activity of a Recombinant Fragment of β-Thymosin of Sea Urchin Paracentrotus lividus 219
DNA-Binding and Anticancer Activity of Pyrene-Imidazolium Derivatives 210
A Synthetic Derivative of Antimicrobial Peptide Holothuroidin 2 from Mediterranean Sea Cucumber (Holothuria tubulosa) in the Control of Listeria monocytogenes 192
Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives 187
Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay 184
(Dipyrido[3,2-a:2',3'-c]phenazine)(glycinato)copper(II) perchlorate: A novel DNA-intercalator with anti-proliferative activity against thyroid cancer cell lines 174
The Interaction of Metal Complexes with G-quadruplex DNA 174
The Binding Mechanism of Epolactaene to Hsp60 Unveiled by in Silico Modelling 172
A peptide from human β thymosin as a platform for the development of new anti-biofilm agents for Staphylococcus spp. and Pseudomonas aeruginosa 155
G-quadruplex vs. duplex-DNA binding of nickel(II) and zinc(II) Schiff base complexes 151
Paracentrin 1, a synthetic antimicrobial peptide from the sea-urchin Paracentrotus lividus, interferes with staphylococcal and Pseudomonas aeruginosa biofilm formation 142
The interaction of Schiff Base complexes of nickel(II) and zinc(II) with duplex and G-quadruplex DNA 138
A Theoretical and Experimental Investigation of the Spectroscopic Properties of a DNA-Intercalator Salphen-Type ZnIIComplex 137
Nickel(II), copper(II) and zinc(II) metallo-intercalators: structural details of the DNA-binding by a combined experimental and computational investigation 134
Circular Dichroism of DNA G-Quadruplexes: Combining Modeling and Spectroscopy to Unravel Complex Structures 131
Quaternary structures of GroEL and naïve-Hsp60 chaperonins in solution: A combined SAXS-MD study 130
Metal ions and metal complexes in Alzheimer’s disease 119
Molecular recognition of naphthalene diimide ligands by telomeric quadruplex-DNA: The importance of the protonation state and mediated hydrogen bonds 112
The Right Answer for the Right Electrostatics: Force Field Methods Are Able to Describe Relative Energies of DNA Guanine Quadruplexes 106
Metal Complex–DNA Binding: Insights from Molecular Dynamics and DFT/MM Calculations 102
The inhibition of glycerol permeation through aquaglyceroporin-3 induced by mercury(II): A molecular dynamics study 101
Targeting G-quadruplexes with organic dyes: Chelerythrine–DNA binding elucidated by combining molecular modeling and optical spectroscopy 88
The Interaction of Small Molecules with Biomolecules 87
Selective G-Quadruplex Stabilizers: Schiff-base Metal Complexes with Anticancer Activity 87
Novel half Salphen cobalt(III) complexes: synthesis, DNA binding and anticancer studies 85
G4-DNA vs. B-DNA binding of Schiff base transition metal complexes 68
The interaction of DNA with metal complexes: experimental and computational studies 66
NiII, and ZnII Schiff Base Complexes: Telomeric G-quadruplex Stabilizers 65
Frontiers of metal-coordinating drug design 65
DNA-Binding of NiII, CuII and ZnII Complexes of Salen Derivatives 55
Ni(II) and Zn(II) Schiff Base complexes: B-DNA vs G4-DNA binding 52
Allosteric Cross-Talk among Spike’s Receptor-Binding Domain Mutations of the SARS-CoV-2 South African Variant Triggers an Effective Hijacking of Human Cell Receptor 49
The catalytic mechanism of steroidogenic cytochromes P450 from all-atom simulations: Entwinement with membrane environment, redox partners, and post-transcriptional regulation 48
The interaction of DNA with metal complexes: computational investigations 47
Exploiting Cryo-EM Structural Information and All-Atom Simulations to Decrypt the Molecular Mechanism of Splicing Modulators 44
Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer 44
All-Atom simulations disclose how cytochrome reductase reshapes the substrate access/egress routes of its partner cyp450s 43
A Novel Peptide with Antifungal Activity from Red Swamp Crayfish Procambarus clarkii 39
How the Metal Ion Affects the 1H NMR Chemical Shift Values of Schiff Base Metal Complexes: Rationalization by DFT Calculations 39
A Dehydrogenase Dual Hydrogen Abstraction Mechanism Promotes Estrogen Biosynthesis: Can We Expand the Functional Annotation of the Aromatase Enzyme? 39
Recent advances in computational design of potent aromatase inhibitors: open-eye on endocrine-resistant breast cancers 39
All-atom simulations to studying metallodrugs/target interactions 39
A Computational Assay of Estrogen Receptor α Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers 38
Molecular Basis of SARS-CoV-2 Nsp1-Induced Immune Translational Shutdown as Revealed by All-Atom Simulations 37
Computing Metal-Binding Proteins for Therapeutic Benefit 36
Can multiscale simulations unravel the function of metallo-enzymes to improve knowledge-based drug discovery? 33
All-atom simulations disentangle the functional dynamics underlying gene maturation in the intron lariat spliceosome 33
How Can Interleukin-1 Receptor Antagonist Modulate Distinct Cell Death Pathways? 32
Is the Rigidity of SARS-CoV-2 Spike Receptor-Binding Motif the Hallmark for Its Enhanced Infectivity? Insights from All-Atom Simulations 29
An omics perspective to the molecular mechanisms of anticancer metallo-drugs in the computational microscope era 28
Switching from Aromatase Inhibitors to Dual Targeting Flavonoid-Based Compounds for Breast Cancer Treatment 26
Anticancer Activity, Reduction Mechanism and G-Quadruplex DNA Binding of a Redox-Activated Platinum(IV)–Salphen Complex 24
Predicting the Three-Dimensional Structure of the c-KIT Proto-Oncogene Promoter and the Dynamics of Its Strongly Coupled Guanine Quadruplexes 24
Mechanism of the Covalent Inhibition of Human Transmembrane Protease Serine 2 as an Original Antiviral Strategy 23
Molecular basis for endocrine disruption by pesticides targeting aromatase and estrogen receptor 23
Investigating the molecular mechanism of h3b‐8800: A splicing modulator inducing preferential lethality in spliceosome‐mutant cancers 23
Targeting Orthosteric and Allosteric Pockets of Aromatase via Dual-Mode Novel Azole Inhibitors 22
Molecular Mechanisms of the Blockage of Glioblastoma Motility 22
Role of computational and structural biology in the development of small-molecule modulators of the spliceosome 20
Post-Translational Regulation of CYP450s Metabolism As Revealed by All-Atoms Simulations of the Aromatase Enzyme 20
The avidin-theophylline complex: A structural and computational study 19
Structural, Thermodynamic, and Kinetic Traits of Antiestrogen-Compounds Selectively Targeting the Y537S Mutant Estrogen Receptor α Transcriptional Activity in Breast Cancer Cell Lines 19
Rational design of allosteric modulators of the aromatase enzyme: An unprecedented therapeutic strategy to fight breast cancer 18
Cancer-Related Mutations Alter RNA-Driven Functional Cross-Talk Underlying Premature-Messenger RNA Recognition by Splicing Factor SF3b 17
Single-digit nanomolar inhibitors lock the aromatase active site via a dualsteric targeting strategy 16
Metal centers and aromatic moieties in Schiff base complexes: impact on G-quadruplex stabilization and oncogene downregulation 14
Resolving the Structure of a Guanine Quadruplex in TMPRSS2 Messenger RNA by Circular Dichroism and Molecular Modeling 1
Unraveling the molecular basis for G‐quadruplex‐binders to ALS/FTD‐associated G4C2 repeats of the C9orf72 gene 1
Totale 4.956
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Categoria #
all - tutte 23.706
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 23.706
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020457 0 0 0 0 0 0 107 78 101 61 77 33
2020/2021527 31 42 46 53 38 35 27 47 55 79 33 41
2021/2022783 33 87 31 17 6 26 17 221 49 90 68 138
2022/2023821 79 179 11 60 72 144 15 59 106 8 57 31
2023/2024446 32 50 45 31 31 61 70 17 3 3 25 78
2024/2025594 78 209 110 106 53 38 0 0 0 0 0 0
Totale 4.956