The duplex and G-quadruplex DNA-binding of six nickel(II) and zinc(II) complexes of three salphen-like ligands (salphen = N,N′-bis-salicylidene-1,2-phenylenediaminato) was investigated by UV–visible absorption and circular dichroism spectroscopy. The results obtained, in particular the values of the DNA-binding constants, Kb, point out that the nickel(II) complexes show a higher affinity toward both duplex and G-quadruplex DNA, compared to the analogous zinc(II) complexes. Interestingly, the zinc(II) complexes possess high selectivity toward G-quadruplex DNA, being negligible their binding with duplex DNA. Molecular dynamics (MD) simulations provided atomistic models for the interpretation of the binding of the zinc(II) complexes with G-quadruplex DNA, allowing a structural comparison of the three salphen-like ligands, due to the presence of different substituents (H, F, CF3) on the position 4 of the phenyl ring on the N,N′ bridge.

Bonsignore, R., Russo, F., Terenzi, A., Spinello, A., Lauria, A., Gennaro, G., et al. (2018). The interaction of Schiff Base complexes of nickel(II) and zinc(II) with duplex and G-quadruplex DNA. JOURNAL OF INORGANIC BIOCHEMISTRY, 178, 106-114 [10.1016/j.jinorgbio.2017.10.010].

The interaction of Schiff Base complexes of nickel(II) and zinc(II) with duplex and G-quadruplex DNA

Bonsignore, Riccardo
Membro del Collaboration Group
;
Terenzi, Alessio
Membro del Collaboration Group
;
Spinello, Angelo
Membro del Collaboration Group
;
Lauria, Antonino
Membro del Collaboration Group
;
Gennaro, Giuseppe
Membro del Collaboration Group
;
Almerico, Anna Maria
Membro del Collaboration Group
;
Barone, Giampaolo
Membro del Collaboration Group
2018-01-01

Abstract

The duplex and G-quadruplex DNA-binding of six nickel(II) and zinc(II) complexes of three salphen-like ligands (salphen = N,N′-bis-salicylidene-1,2-phenylenediaminato) was investigated by UV–visible absorption and circular dichroism spectroscopy. The results obtained, in particular the values of the DNA-binding constants, Kb, point out that the nickel(II) complexes show a higher affinity toward both duplex and G-quadruplex DNA, compared to the analogous zinc(II) complexes. Interestingly, the zinc(II) complexes possess high selectivity toward G-quadruplex DNA, being negligible their binding with duplex DNA. Molecular dynamics (MD) simulations provided atomistic models for the interpretation of the binding of the zinc(II) complexes with G-quadruplex DNA, allowing a structural comparison of the three salphen-like ligands, due to the presence of different substituents (H, F, CF3) on the position 4 of the phenyl ring on the N,N′ bridge.
2018
Settore CHIM/03 - Chimica Generale E Inorganica
Bonsignore, R., Russo, F., Terenzi, A., Spinello, A., Lauria, A., Gennaro, G., et al. (2018). The interaction of Schiff Base complexes of nickel(II) and zinc(II) with duplex and G-quadruplex DNA. JOURNAL OF INORGANIC BIOCHEMISTRY, 178, 106-114 [10.1016/j.jinorgbio.2017.10.010].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/252304
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