Archivio istituzionale della ricerca dell'Università degli Studi di Palermo

TUTONE, Marco
 Distribuzione geografica
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Continente #
NA - Nord America 5.817
EU - Europa 3.164
AS - Asia 1.231
AF - Africa 86
SA - Sud America 31
OC - Oceania 20
Continente sconosciuto - Info sul continente non disponibili 4
Totale 10.353
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Nazione #
US - Stati Uniti d'America 5.789
IT - Italia 1.515
CN - Cina 595
FI - Finlandia 331
SG - Singapore 325
UA - Ucraina 295
DE - Germania 234
IE - Irlanda 218
GB - Regno Unito 152
IN - India 115
RU - Federazione Russa 75
FR - Francia 67
CI - Costa d'Avorio 64
SE - Svezia 51
JP - Giappone 46
BE - Belgio 41
RO - Romania 37
NL - Olanda 35
ES - Italia 29
KR - Corea 29
IR - Iran 21
TR - Turchia 21
AU - Australia 20
BR - Brasile 18
MX - Messico 18
AT - Austria 15
HK - Hong Kong 15
CH - Svizzera 13
BG - Bulgaria 12
PL - Polonia 11
DZ - Algeria 10
GR - Grecia 10
CA - Canada 9
CZ - Repubblica Ceca 9
TW - Taiwan 9
VN - Vietnam 9
PK - Pakistan 8
UZ - Uzbekistan 7
LB - Libano 6
CL - Cile 5
EG - Egitto 5
JO - Giordania 4
MY - Malesia 4
NO - Norvegia 4
EU - Europa 3
IL - Israele 3
IQ - Iraq 3
PE - Perù 3
PT - Portogallo 3
QA - Qatar 3
ZA - Sudafrica 3
DK - Danimarca 2
EC - Ecuador 2
LK - Sri Lanka 2
LU - Lussemburgo 2
NG - Nigeria 2
SA - Arabia Saudita 2
UY - Uruguay 2
A2 - ???statistics.table.value.countryCode.A2??? 1
BO - Bolivia 1
GL - Groenlandia 1
HU - Ungheria 1
ID - Indonesia 1
KH - Cambogia 1
LT - Lituania 1
MA - Marocco 1
PS - Palestinian Territory 1
RS - Serbia 1
TH - Thailandia 1
TN - Tunisia 1
Totale 10.353
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Città #
Fairfield 751
Palermo 575
Ashburn 541
Chandler 463
Woodbridge 418
Houston 374
Ann Arbor 349
Wilmington 335
Seattle 288
Singapore 275
Cambridge 260
Dublin 212
Medford 163
Jacksonville 157
Nanjing 118
Princeton 107
Des Moines 71
Altamura 67
Abidjan 63
New York 63
Dearborn 55
San Diego 54
Boardman 51
Lawrence 51
Milan 51
Hyderabad 50
Beijing 47
Tulsa 46
Shenyang 43
Jinan 42
Ludwigshafen am Rhein 40
Hebei 38
Santa Clara 38
Redwood City 31
Changsha 30
Nanchang 29
Rome 29
London 27
Tianjin 27
Brussels 26
Columbus 25
Jiaxing 24
Zhengzhou 24
Bremen 23
Napoli 21
Paris 19
Amsterdam 17
Helsinki 17
Los Angeles 17
Philadelphia 17
Catania 16
Taizhou 16
Tokyo 16
Ningbo 15
Berlin 14
Cefalù 14
Seongnam 14
Taiyuan 13
Washington 13
Cagliari 12
Haikou 12
Kilburn 12
Atlanta 11
Auburn Hills 11
Aversa 11
Messina 11
Barcelona 10
Edinburgh 10
Guangzhou 10
Phoenix 10
Saint Petersburg 10
Sofia 10
Verona 10
Florence 9
Kumar 9
Norwalk 9
Seoul 9
Trapani 9
Apeldoorn 8
Hangzhou 8
Sydney 8
Bengaluru 7
Brno 7
Chikmagalūr 7
Foggia 7
Lappeenranta 7
San Paolo di Civitate 7
Southwark 7
Stockholm 7
Baltimore 6
Bonn 6
Brisbane 6
Carini 6
Chicago 6
Frankfurt 6
Hefei 6
Hong Kong 6
Kunming 6
Leuven 6
Naples 6
Totale 7.131
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Nome #
Deciphering the Nonsense Readthrough Mechanism of Action of Ataluren: An in Silico Compared Study 265
In vitro and in silico studies of polycondensed diazine systems as anti-parasitic agents 178
Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies 174
3D-QSAR Pharmacophore Modeling and in Silico Screening of new Bcl-xl Inhibitors 173
Inhibition of FTSJ1, a tryptophan tRNA-specific 2’-O-methyltransferase as possible mechanism to readthrough premature termination codons (UGAs) of the CFTR mRNA 167
Uno studio comparativo in silico sui possibili target di Ataluren e analoghi farmaci promotori di readthrough di codoni di stop prematuri 165
Predicting Skin Permeability by Means of Computational Approaches: Reliability and Caveats in Pharmaceutical Studies 165
Studies on a new potential dopaminergic agent: in vitro BBB permeability, in vivo behavioural effects and molecular docking evaluation 164
Trans-epithelial transport of the betalain pigments indicaxanthin and betanin across Caco-2 cell monolayers and influence of food matrix 163
A Multivariate Analysis of HIV-1 Protease Inhibitors and Resistance Induced by Mutation 162
P015 Translational readthrough inducing drugs: a study of toxicity in mice models and in vitro safety validation of the specific readthrough process. 161
Phytochemical Indicaxanthin Inhibits Colon Cancer Cell Growth and Affects the DNA Methylation Status by Influencing Epigenetically Modifying Enzyme Expression and Activity 160
Theoretical Determination of the pK a Values of Betalamic Acid Related to the Free Radical Scavenger Capacity: Comparison Between Empirical and Quantum Chemical Methods 159
Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening 154
Molecular Dynamics studies on Mdm2 complexes: an analysis of the inhibitor influence 152
A multivariate analysis on non-nucleoside HIV-1 reverse transcriptase inhibitors and resistance induced by mutation 152
Receptor-guided 3D-QSAR approach for the discovery of c-kit tyrosine kinase inhibitors 151
A3 adenosine receptor: Homology modeling and 3D-QSAR studies 147
In-silico screening of new potential Bcl-2/Bcl-xl inhibitors as apoptosis modulators 141
Derivati Ossadiazolici per il trattamento della fibrosi cistica: Readthrough di mutazioni nonsense 139
A multivariate analysis on HIV-1 protease inhibitors and resistance induced by mutation 138
Indicaxanthin from Opuntia ficus-indica Crosses the Blood−Brain Barrier and Modulates Neuronal Bioelectric Activity in Rat Hippocampus at Dietary-Consistent Amounts. 138
Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs 136
Study of the role of “gatekeeper” mutations V654A and T670I of c-kit kinase in the interaction with inhibitors by means mixed molecular dynamics/docking approach 135
Does ligand symmetry play a role in the stabilization of DNA g-quadruplex host-guest complexes? 134
Molecular modelling and QSAR in the discovery of HIV-1 integrase inhibitors 132
DOCKING AND MULTIVARIATE METHODS TO EXPLORE HIV-1 DRUG-RESISTANCE: A COMPARATIVE ANALYSIS 131
A QSAR study investigating the potential anti-HIV-1 effect of some Acyclovir and Ganciclovir analogs 129
Micelles of the chiral biocompatible surfactant (1R,2S)-dodecyl-(2-hydroxy-1-methyl-2-phenylethyl)dimethylammonium bromide (DMEB): Molecular dynamics and fragmentation patterns in the gas phase 125
Conf-VLKA: A structure-based revisitation of the Virtual Lock-and-key Approach 123
Targeting nonsense: Optimization of 1,2,4-oxadiazole trids to rescue cftr expression and functionality in cystic fibrosis cell model systems 123
Design, synthesis and preliminary evaluation of dopamine-amino acid conjugates as potential D1 dopaminergic modulators 116
Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) 115
Micelles, Rods, Liposomes, and Other Supramolecular Surfactant Aggregates: Computational Approaches 114
Recent advances on CDK inhibitors: An insight by means of in silico methods 113
A3 Adenosine Receptor: homology modeling and 3D-QSAR studies 112
Molecular dynamics, dynamic site mapping, and highthroughput virtual screening on leptin and the Ob receptor as anti-obesity target 108
Exploring the SARS-CoV-2 proteome in the search of potential inhibitors via structure-based pharmacophore modeling/docking approach 107
IKK-beta inhibitors: An analysis of drug–receptor interaction by using Molecular Docking and Pharmacophore 3D-QSAR approaches 105
Pharmacophore modelling as useful tool in the lead compounds identification and optimization 105
Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells 104
In Vitro Modulation of P-Glycoprotein Activity by Euphorbia intisy Essential Oil on Acute Myeloid Leukemia Cell Line HL-60R 104
A Molecular Dynamics-Shared Pharmacophore Approach to Boost Early-Enrichment Virtual Screening: A Case Study on Peroxisome Proliferator-Activated Receptor α 103
Pharmacophore-Based Design of New Chemical Scaffolds as Translational Readthrough-Inducing Drugs (TRIDs) 101
Design of new DNA-interactive agents by molecular docking and QSPR approach 100
Molecular Modeling Approaches in the Discovery of New Drugs for Anti-Cancer Therapy: The Investigation of p53-MDM2 Interaction and its Inhibition by Small Molecules 95
Bcl-2 come target di farmaci antitumorali modulatori dell'apoptosi 90
Virtual lock-and-key approach: The in silico revival of Fischer model by means of molecular descriptors 90
IN THE SEARCH OF LEPTIN AGONISTS AS ANTI-OBESITY DRUGS: PROTEIN/PROTEIN DOCKING, MOLECULAR DYNAMICS, AND VIRTUAL SCREENING 89
Reverse Screening on Indicaxanthin from Opuntia ficus-indica as natural chemoactive and chemopreventive agent 88
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells 85
Molecular Modelling on Leptin and the Ob Receptor as anti-obesity target 84
Multivariate analysis in the identification of biological targets for designed molecular structures: The BIOTA protocol 83
Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs 83
CHA on CDK2: a way to identify the best pharmacophore model for the virtual screening of new inhibitors 83
Leptin and the ob-receptor as anti-obesity target: recent in silico advances in the comprehension of the protein-protein interaction and rational drug design of anti-obesity lead compounds 81
Reverse screening on indicaxanthin from Opuntia ficus-indica as natural chemoactive and chemopreventive agent 81
Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution evaluation in mice models 80
QSAR and molecular docking techniques in the study of HIV-1 inhibitors 79
Analisi Multivariata e Docking nello Studio degli Inibitori di HIV-1 Integrasi 79
Identification of a new molecule with readthrough activity to rescue CFTR protein function 79
DA-Phen, a new dopamine aminoacid conjugate: in vivo testing and molecular modeling as dopaminergic modulator 77
METODI CHEMIOMETRICI NELLO STUDIO DEGLI INIBITORI DI HIV-1: TECNICHE STATITICHE MULTIVARIATE E MOLECULAR DOCKING 76
HIV-1 Protease Inhibitors and Resistance Induced by Mutation. Correlation between Multivariate Analysis and Molecular Docking. 75
TECNICHE DI MODELLISTICA MOLECOLARE NELLA PROGETTAZIONE DI INIBITORI DELL'ATTIVITÀ TRASCRIZIONALE DI HIF-1 75
Readthrough Inducing Drugs (TRIDs) in human fibroblasts harboring the c.5047 C>T (R1683*) nonsense mutation 74
A definitive pharmacophore modelling study on CDK2 ATP pocket binders: Tracing the path of new virtual high-throughput screenings 73
Studio del ruolo delle mutazioni “gatekeeper” V654A e T670I di c-kit kinase nell’interazione con inibitori attraverso un approccio misto Dinamica Molecolare/Docking 70
Nonsense codons suppression. An acute toxicity study of three optimized TRIDs in murine model, safety and tolerability evaluation 69
Investigation on MMACHC-R161Q pathological mutant from cblC disease 69
Molecular Modeling and Dynamics of the transcriptionfactor NF-kB complexed with IkB 69
Studi di dinamica molecolare su Mdm2 legata a due differenti inibitori 68
Phytol and heptacosane: the two major components of Euphorbia intisy essential oil with biological activities in drug resistant leukemia cell. 67
Study on the mechanism of action of antitumor photochemotherapic agents by means of docking and QSPR analysis 66
Comparing molecular dynamics-derived pharmacophore models with docking: A study on CDK-2 inhibitors 66
Sulfonamide moiety as "molecular chimera" in the design of new drugs 65
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the readthrough of PTCs in CF cells 64
Computational methodologies in the discovery of inhibitors of HIV-1 63
Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells 63
MOLECULAR DYNAMICS - MULTIPLE RECEPTOR CONFORMATIONS APPROACH TO ENHANCE STRUCTURE-BASED VIRTUAL SCREENING ON PPAR-alpha RECEPTOR 63
MOLECULAR DYNAMICS AND DOCKING IN THE STUDY OF NEW INHIBITORS OF MDM2-p53 INTERACTION 62
The in silico fischer lock-and-key model: The combined use of molecular descriptors and docking poses for the repurposing of old drugs 62
Investigation on quantitative structure-activity relationships of 1,3,4-oxadiazole derivatives as potential telomerase inhibitors 62
Phytol and Heptacosane Are Possible Tools to Overcome Multidrug Resistance in an In Vitro Model of Acute Myeloid Leukemia 62
Consensus modelling and molecular dynamics studies for the identification of novel telomerase inhibitors as anti-cancer agents 58
Immunoproteasome and Non-Covalent Inhibition: Exploration by Advanced Molecular Dynamics and Docking Methods 58
Farmaci anti-HIV-1. Correlazioni tra analisi statistica multivariata e docking molecolare 57
Inside c-kit tyrosine kinase: molecular modeling and QSAR in the search of new inhibitors 57
In vitro and in silico studies of polycondensed diazine systems as anti-infective agents 57
THE DISCOVERY OF NEW HIF-1 INHIBITORS THROUGH MOLECULAR MODELING STUDIES 55
TOWARD ENRICHED VHTS FOR CDK2 INHIBITORS: MOLECULAR DYNAMICS, PHARMACOPHORE MODELLING, AND DOCKING 55
The discovery of new inhibitors of HIF-1 transcriptional activity by virtual screening 54
Virtual lock and key approach: the revival of Fischer model 53
INVESTIGATION ON MMACHC-R161Q PATHOLOGICAL MUTANT FROM cblC DISEASE, A RARE METABOLIC DISORDER OF VITAMIN B12 METABOLISM 53
Synthesis, In Vitro and In Silico Analysis of New Oleanolic Acid and Lupeol Derivatives against Leukemia Cell Lines: Involvement of the NF-κB Pathway 52
Pharmacophore modeling e screening in silico di nuovi inibitori della proteina antiapoptotica Bcl-xl 51
A dynamic multiple receptor conformations (MD-MRC) approach to enhance early enrichment in virtual screening. A case study on PPAR-alpha 51
OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS 50
Exploring the non-covalent ligand-binding mechanism on immunoproteasome by enhanced Molecular Dynamics 49
Computational Approaches: Drug Discovery and Design in Medicinal Chemistry and Bioinformatics 49
Totale 10.011
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Categoria #
all - tutte 42.809
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 42.809
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.561 0 0 0 0 227 312 220 142 202 119 253 86
2020/20211.434 67 119 38 129 190 76 105 110 151 185 116 148
2021/20221.316 90 236 30 34 21 61 58 86 150 160 94 296
2022/20231.828 202 220 49 239 208 273 102 138 171 47 101 78
2023/20241.261 75 137 57 64 112 192 143 115 22 80 63 201
2024/2025866 136 135 162 359 74 0 0 0 0 0 0 0
Totale 11.082