Archivio istituzionale della ricerca dell'Università degli Studi di Palermo

TUTONE, Marco
 Distribuzione geografica
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Continente #
NA - Nord America 9.174
EU - Europa 6.903
AS - Asia 5.499
SA - Sud America 959
AF - Africa 223
OC - Oceania 27
Continente sconosciuto - Info sul continente non disponibili 17
Totale 22.802
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Nazione #
US - Stati Uniti d'America 8.974
IT - Italia 2.263
SG - Singapore 1.695
RU - Federazione Russa 1.603
CN - Cina 1.417
BR - Brasile 711
VN - Vietnam 548
HK - Hong Kong 514
FI - Finlandia 483
DE - Germania 476
PL - Polonia 352
FR - Francia 331
UA - Ucraina 322
JP - Giappone 284
GB - Regno Unito 271
IN - India 248
IE - Irlanda 239
BD - Bangladesh 164
NL - Olanda 124
KR - Corea 100
ES - Italia 87
MX - Messico 86
AR - Argentina 79
CA - Canada 74
TR - Turchia 74
AT - Austria 71
SE - Svezia 70
IQ - Iraq 67
CI - Costa d'Avorio 66
BE - Belgio 45
IR - Iran 44
PK - Pakistan 44
ZA - Sudafrica 44
ID - Indonesia 42
EC - Ecuador 41
RO - Romania 38
UZ - Uzbekistan 37
IL - Israele 31
CH - Svizzera 29
VE - Venezuela 28
AU - Australia 27
CL - Cile 27
PY - Paraguay 25
CO - Colombia 24
DZ - Algeria 24
SA - Arabia Saudita 23
MA - Marocco 22
MY - Malesia 22
PT - Portogallo 21
EG - Egitto 20
CZ - Repubblica Ceca 15
NP - Nepal 14
PH - Filippine 14
BG - Bulgaria 13
JO - Giordania 13
TN - Tunisia 13
TW - Taiwan 13
XK - ???statistics.table.value.countryCode.XK??? 13
AE - Emirati Arabi Uniti 11
JM - Giamaica 11
GR - Grecia 10
LT - Lituania 10
KZ - Kazakistan 9
BO - Bolivia 8
LB - Libano 8
NG - Nigeria 8
PE - Perù 8
SY - Repubblica araba siriana 8
BH - Bahrain 7
TH - Thailandia 7
UY - Uruguay 7
AL - Albania 6
KE - Kenya 6
PA - Panama 6
DK - Danimarca 5
QA - Qatar 5
ET - Etiopia 4
GE - Georgia 4
HN - Honduras 4
KH - Cambogia 4
LK - Sri Lanka 4
NO - Norvegia 4
PS - Palestinian Territory 4
AZ - Azerbaigian 3
BB - Barbados 3
BN - Brunei Darussalam 3
CR - Costa Rica 3
DO - Repubblica Dominicana 3
EU - Europa 3
OM - Oman 3
RS - Serbia 3
AM - Armenia 2
BS - Bahamas 2
BY - Bielorussia 2
CY - Cipro 2
GA - Gabon 2
KG - Kirghizistan 2
KW - Kuwait 2
LU - Lussemburgo 2
LV - Lettonia 2
Totale 22.769
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Città #
Ashburn 1.148
Singapore 1.131
Palermo 804
Fairfield 751
San Jose 695
Hong Kong 473
Chandler 463
Woodbridge 418
Houston 391
Ann Arbor 349
Wilmington 336
Zgierz 312
Seattle 299
Cambridge 260
Moscow 254
Dublin 233
Tokyo 223
Beijing 218
Council Bluffs 215
Ho Chi Minh City 207
Medford 163
Jacksonville 158
Helsinki 146
Los Angeles 145
Dallas 144
Lauterbourg 142
New York 142
Santa Clara 125
Nanjing 121
Hanoi 114
Frankfurt am Main 113
Hefei 110
Princeton 107
Rome 100
Boardman 96
Milan 85
Des Moines 81
The Dalles 80
Buffalo 73
Altamura 67
Abidjan 65
São Paulo 63
Hyderabad 61
Dearborn 55
San Diego 55
Lawrence 51
London 50
Tulsa 46
Shenyang 45
Jinan 44
Columbus 41
Amsterdam 40
Ludwigshafen am Rhein 40
Changsha 38
Hebei 38
Philadelphia 38
Chicago 37
Orem 35
Paris 35
Da Nang 34
Redwood City 32
Tianjin 31
Atlanta 30
Chennai 30
Brussels 29
Nanchang 29
Munich 28
Nuremberg 28
Partanna 27
Vienna 27
Barcelona 26
Zhengzhou 26
Guangzhou 25
Tashkent 25
Jiaxing 24
Warsaw 24
Bremen 23
Catania 23
Corciano 22
Mexico City 22
Naples 22
Rio de Janeiro 22
Brooklyn 21
Mumbai 21
Napoli 21
Phoenix 21
Tel Aviv 21
Belo Horizonte 20
Johannesburg 20
Lappeenranta 20
Perugia 20
Ha Kwai Chung 19
Istanbul 19
Redondo Beach 19
Toronto 19
Birmingham 18
Haiphong 18
Montreal 18
Stockholm 18
Baghdad 17
Totale 13.328
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Nome #
Deciphering the Nonsense Readthrough Mechanism of Action of Ataluren: An in Silico Compared Study 319
Inhibition of FTSJ1, a tryptophan tRNA-specific 2’-O-methyltransferase as possible mechanism to readthrough premature termination codons (UGAs) of the CFTR mRNA 291
In vitro and in silico studies of polycondensed diazine systems as anti-parasitic agents 286
P015 Translational readthrough inducing drugs: a study of toxicity in mice models and in vitro safety validation of the specific readthrough process. 279
A Multivariate Analysis of HIV-1 Protease Inhibitors and Resistance Induced by Mutation 278
3D-QSAR Pharmacophore Modeling and in Silico Screening of new Bcl-xl Inhibitors 258
Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies 241
A comprehensive computational analysis of NR2F2/6 receptors for drug repurposing 240
A3 adenosine receptor: Homology modeling and 3D-QSAR studies 236
A multivariate analysis on non-nucleoside HIV-1 reverse transcriptase inhibitors and resistance induced by mutation 234
A multivariate analysis on HIV-1 protease inhibitors and resistance induced by mutation 232
Uno studio comparativo in silico sui possibili target di Ataluren e analoghi farmaci promotori di readthrough di codoni di stop prematuri 230
Molecular Dynamics studies on Mdm2 complexes: an analysis of the inhibitor influence 225
Does ligand symmetry play a role in the stabilization of DNA g-quadruplex host-guest complexes? 223
Derivati Ossadiazolici per il trattamento della fibrosi cistica: Readthrough di mutazioni nonsense 223
Trans-epithelial transport of the betalain pigments indicaxanthin and betanin across Caco-2 cell monolayers and influence of food matrix 220
Receptor-guided 3D-QSAR approach for the discovery of c-kit tyrosine kinase inhibitors 217
Studies on a new potential dopaminergic agent: in vitro BBB permeability, in vivo behavioural effects and molecular docking evaluation 217
A QSAR study investigating the potential anti-HIV-1 effect of some Acyclovir and Ganciclovir analogs 215
Molecular modelling and QSAR in the discovery of HIV-1 integrase inhibitors 214
A3 Adenosine Receptor: homology modeling and 3D-QSAR studies 213
Phytochemical Indicaxanthin Inhibits Colon Cancer Cell Growth and Affects the DNA Methylation Status by Influencing Epigenetically Modifying Enzyme Expression and Activity 211
Indicaxanthin from Opuntia ficus-indica Crosses the Blood−Brain Barrier and Modulates Neuronal Bioelectric Activity in Rat Hippocampus at Dietary-Consistent Amounts. 209
Predicting Skin Permeability by Means of Computational Approaches: Reliability and Caveats in Pharmaceutical Studies 205
Micelles of the chiral biocompatible surfactant (1R,2S)-dodecyl-(2-hydroxy-1-methyl-2-phenylethyl)dimethylammonium bromide (DMEB): Molecular dynamics and fragmentation patterns in the gas phase 202
Theoretical Determination of the pK a Values of Betalamic Acid Related to the Free Radical Scavenger Capacity: Comparison Between Empirical and Quantum Chemical Methods 199
Biophysical characterization of MMACHC mutants: towards targeted therapies for the vitamin B12 metabolism disorder cblC 198
Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) 198
Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening 197
Pharmacophore-Based Design of New Chemical Scaffolds as Translational Readthrough-Inducing Drugs (TRIDs) 197
Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs 194
Exploring the SARS-CoV-2 proteome in the search of potential inhibitors via structure-based pharmacophore modeling/docking approach 194
A Molecular Dynamics-Shared Pharmacophore Approach to Boost Early-Enrichment Virtual Screening: A Case Study on Peroxisome Proliferator-Activated Receptor α 192
Molecular Modelling on Leptin and the Ob Receptor as anti-obesity target 191
Nonsense codons suppression. An acute toxicity study of three optimized TRIDs in murine model, safety and tolerability evaluation 190
Pharmacophore modelling as useful tool in the lead compounds identification and optimization 190
RESTORING MMACHC EXPRESSION: TRIDs AS A PROMISING APPROACH FOR cblC DEFICIENCY TREATMENT 188
Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution evaluation in mice models 187
Study of the role of “gatekeeper” mutations V654A and T670I of c-kit kinase in the interaction with inhibitors by means mixed molecular dynamics/docking approach 185
In-silico screening of new potential Bcl-2/Bcl-xl inhibitors as apoptosis modulators 183
FTSJ1 INHIBITION AS A STRATEGY FOR NONSENSE MUTATION SUPPRESSION IN TP53: INTEGRATIVE COMPUTATIONAL AND EXPERIMENTAL ANALYSIS 182
Design, synthesis and preliminary evaluation of dopamine-amino acid conjugates as potential D1 dopaminergic modulators 182
NEW TRANSLATIONAL READTHROUGH INDUCING DRUGS RESCUING NONSENSE MUTATED TP53: STRATEGIES AGAINST CANCER 181
Micelles, Rods, Liposomes, and Other Supramolecular Surfactant Aggregates: Computational Approaches 180
IKK-beta inhibitors: An analysis of drug–receptor interaction by using Molecular Docking and Pharmacophore 3D-QSAR approaches 179
INVESTIGATION ON MMACHC-R161Q PATHOLOGICAL MUTANT FROM cblC DISEASE, A RARE METABOLIC DISORDER OF VITAMIN B12 METABOLISM 178
Conf-VLKA: A structure-based revisitation of the Virtual Lock-and-key Approach 177
Targeting nonsense: Optimization of 1,2,4-oxadiazole trids to rescue cftr expression and functionality in cystic fibrosis cell model systems 177
Potential translational readthough inducin drugs: an optimized design and synthesis of new chemical scaffolds 174
IN THE SEARCH OF LEPTIN AGONISTS AS ANTI-OBESITY DRUGS: PROTEIN/PROTEIN DOCKING, MOLECULAR DYNAMICS, AND VIRTUAL SCREENING 171
Bcl-2 come target di farmaci antitumorali modulatori dell'apoptosi 170
Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells 170
A definitive pharmacophore modelling study on CDK2 ATP pocket binders: Tracing the path of new virtual high-throughput screenings 170
Readthrough Inducing Drugs (TRIDs) in human fibroblasts harboring the c.5047 C>T (R1683*) nonsense mutation 164
Investigating the inhibition of FTSJ1 a tryptophan tRNA-specific 2’-O-methyltransferase by NV TRIDs, as a mechanism of readthrough in nonsense mutated CFTR 163
Phytol and heptacosane: the two major components of Euphorbia intisy essential oil with biological activities in drug resistant leukemia cell. 163
Promoting readthrough of nonsense mutations in CF mouse model: Biodistribution and efficacy of NV848 in rescuing CFTR protein expression 162
DOCKING AND MULTIVARIATE METHODS TO EXPLORE HIV-1 DRUG-RESISTANCE: A COMPARATIVE ANALYSIS 161
DA-Phen, a new dopamine aminoacid conjugate: in vivo testing and molecular modeling as dopaminergic modulator 160
INVESTIGATING THE NR2F2 STRUCTURE FOR DRUG REPURPOSING 157
Investigation on MMACHC-R161Q pathological mutant from cblC disease 157
Analisi Multivariata e Docking nello Studio degli Inibitori di HIV-1 Integrasi 157
Design of small molecules and identification of putative anticancer therapeutic targets via in silico tools 156
In Vitro Modulation of P-Glycoprotein Activity by Euphorbia intisy Essential Oil on Acute Myeloid Leukemia Cell Line HL-60R 154
RESCUING P53 BY NEW TRANSLATIONAL READTHROUGH INDUCING DRUGS 153
Virtual lock-and-key approach: The in silico revival of Fischer model by means of molecular descriptors 153
Design of new DNA-interactive agents by molecular docking and QSPR approach 152
Molecular Modeling Approaches in the Discovery of New Drugs for Anti-Cancer Therapy: The Investigation of p53-MDM2 Interaction and its Inhibition by Small Molecules 152
Molecular dynamics, dynamic site mapping, and highthroughput virtual screening on leptin and the Ob receptor as anti-obesity target 151
Multivariate analysis in the identification of biological targets for designed molecular structures: The BIOTA protocol 149
Recent advances on CDK inhibitors: An insight by means of in silico methods 149
CHA on CDK2: a way to identify the best pharmacophore model for the virtual screening of new inhibitors 145
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells 144
METODI CHEMIOMETRICI NELLO STUDIO DEGLI INIBITORI DI HIV-1: TECNICHE STATITICHE MULTIVARIATE E MOLECULAR DOCKING 143
Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs 142
Unlocking Cellular Secrets: Charting Proteomic Frontiers in LRBA Deficiency Through the Lens of Readthrough Promoters 141
A dynamic-common pharmacophore approach to improve virtual screening. A case study on PPAR-alpha 141
Identification of New Translational Readthrough Inducing Drugs 140
CFTR G542X/ G542X mouse model carrying nonsense mutations, useful tool to test the efficacy of translational readthrough-based therapy in Cystic Fibrosis 138
Chaperoning system: Intriguing target to modulate the expression of CFTR in cystic fibrosis 137
A Fragile Protein Strengthened by Vitamin Intake, a Simulation Study of the Mmachc 137
The discovery of new inhibitors of HIF-1 transcriptional activity by virtual screening 136
Natural products as non-covalent and covalent modulators of the KEAP1/NRF2 pathway exerting antioxidant effects 135
Inside c-kit tyrosine kinase: molecular modeling and QSAR in the search of new inhibitors 133
TECNICHE DI MODELLISTICA MOLECOLARE NELLA PROGETTAZIONE DI INIBITORI DELL'ATTIVITÀ TRASCRIZIONALE DI HIF-1 133
In vitro and in silico studies of polycondensed diazine systems as anti-infective agents 132
Aminoquinolines: Fluorescent sensors to DNA – A minor groove probe. Experimental and in silico studies 132
A precision medicine approach to primary immunodeficiency disease: Ataluren strikes nonsense mutations once again 131
A dynamic multiple receptor conformations (MD-MRC) approach to enhance early enrichment in virtual screening. A case study on PPAR-alpha 131
QSAR and molecular docking techniques in the study of HIV-1 inhibitors 130
Leptin and the ob-receptor as anti-obesity target: recent in silico advances in the comprehension of the protein-protein interaction and rational drug design of anti-obesity lead compounds 130
HIV-1 Protease Inhibitors and Resistance Induced by Mutation. Correlation between Multivariate Analysis and Molecular Docking. 129
Studio del ruolo delle mutazioni “gatekeeper” V654A e T670I di c-kit kinase nell’interazione con inibitori attraverso un approccio misto Dinamica Molecolare/Docking 129
Evaluation of the IKKβ Binding of Indicaxanthin by Induced-Fit Docking, Binding Pose Metadynamics, and Molecular Dynamics 128
Identification of a new molecule with readthrough activity to rescue CFTR protein function 127
The in silico fischer lock-and-key model: The combined use of molecular descriptors and docking poses for the repurposing of old drugs 127
Studi di dinamica molecolare su Mdm2 legata a due differenti inibitori 125
Sulfonamide moiety as "molecular chimera" in the design of new drugs 124
Investigation on quantitative structure-activity relationships of 1,3,4-oxadiazole derivatives as potential telomerase inhibitors 124
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the readthrough of PTCs in CF cells 123
Totale 17.772
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Categoria #
all - tutte 76.785
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 76.785
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021148 0 0 0 0 0 0 0 0 0 0 0 148
2021/20221.316 90 236 30 34 21 61 58 86 150 160 94 296
2022/20231.828 202 220 49 239 208 273 102 138 171 47 101 78
2023/20241.261 75 137 57 64 112 192 143 115 22 80 63 201
2024/20253.418 136 135 162 359 160 197 203 327 229 418 367 725
2025/202610.105 713 305 691 975 889 1.377 1.547 1.064 823 1.027 429 265
Totale 23.739