Archivio istituzionale della ricerca dell'Università degli Studi di Palermo

TUTONE, Marco
 Distribuzione geografica
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Continente #
NA - Nord America 11.277
EU - Europa 7.198
AS - Asia 5.669
SA - Sud America 1.075
Continente sconosciuto - Info sul continente non disponibili 993
AF - Africa 230
OC - Oceania 29
Totale 26.471
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Nazione #
US - Stati Uniti d'America 10.945
IT - Italia 2.449
SG - Singapore 1.700
RU - Federazione Russa 1.604
CN - Cina 1.432
BR - Brasile 754
VN - Vietnam 556
HK - Hong Kong 531
DE - Germania 488
FI - Finlandia 483
PL - Polonia 354
FR - Francia 347
UA - Ucraina 323
GB - Regno Unito 291
JP - Giappone 291
IN - India 259
IE - Irlanda 239
BD - Bangladesh 201
CA - Canada 143
KR - Corea 130
NL - Olanda 130
MX - Messico 101
ES - Italia 96
SE - Svezia 95
AR - Argentina 92
TR - Turchia 74
AT - Austria 71
IQ - Iraq 68
CI - Costa d'Avorio 66
EC - Ecuador 54
CO - Colombia 49
PK - Pakistan 49
ID - Indonesia 48
BE - Belgio 45
IR - Iran 44
ZA - Sudafrica 44
VE - Venezuela 41
RO - Romania 38
UZ - Uzbekistan 37
CH - Svizzera 34
IL - Israele 31
AU - Australia 29
CL - Cile 29
PT - Portogallo 27
SA - Arabia Saudita 27
DZ - Algeria 26
MY - Malesia 26
PY - Paraguay 26
MA - Marocco 22
JM - Giamaica 21
EG - Egitto 20
PH - Filippine 19
TW - Taiwan 16
CZ - Repubblica Ceca 15
JO - Giordania 15
NP - Nepal 15
BG - Bulgaria 13
CR - Costa Rica 13
TN - Tunisia 13
XK - ???statistics.table.value.countryCode.XK??? 13
TH - Thailandia 12
AE - Emirati Arabi Uniti 11
PE - Perù 11
GR - Grecia 10
LT - Lituania 10
BO - Bolivia 9
KZ - Kazakistan 9
PA - Panama 9
KE - Kenya 8
LB - Libano 8
NG - Nigeria 8
SY - Repubblica araba siriana 8
UY - Uruguay 8
BH - Bahrain 7
HN - Honduras 7
QA - Qatar 7
TT - Trinidad e Tobago 7
AL - Albania 6
DK - Danimarca 5
NI - Nicaragua 5
OM - Oman 5
RS - Serbia 5
BB - Barbados 4
BY - Bielorussia 4
ET - Etiopia 4
GE - Georgia 4
KH - Cambogia 4
LK - Sri Lanka 4
NO - Norvegia 4
PS - Palestinian Territory 4
SV - El Salvador 4
AZ - Azerbaigian 3
BN - Brunei Darussalam 3
DO - Repubblica Dominicana 3
EU - Europa 3
GT - Guatemala 3
PR - Porto Rico 3
AM - Armenia 2
BS - Bahamas 2
BZ - Belize 2
Totale 25.447
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Città #
Ashburn 1.389
San Jose 1.172
Singapore 1.136
Palermo 840
Fairfield 752
Hong Kong 481
Chandler 463
Woodbridge 418
Houston 396
Ann Arbor 349
Wilmington 337
Council Bluffs 334
Zgierz 312
Seattle 304
Cambridge 261
Moscow 254
Dublin 234
Tokyo 227
Beijing 222
Ho Chi Minh City 211
Los Angeles 182
New York 174
Jacksonville 165
Medford 163
Dallas 161
Helsinki 146
Lauterbourg 142
Santa Clara 137
Nanjing 121
Hanoi 116
Rome 114
Frankfurt am Main 113
Hefei 110
Milan 109
Princeton 107
Boardman 101
Chicago 96
The Dalles 84
Des Moines 81
Buffalo 78
Altamura 67
Abidjan 65
São Paulo 65
Hyderabad 62
San Diego 61
Dearborn 55
Lawrence 52
London 51
Philadelphia 48
Tulsa 46
Shenyang 45
Columbus 44
Jinan 44
Atlanta 43
Phoenix 43
Amsterdam 42
Ludwigshafen am Rhein 40
Brooklyn 38
Changsha 38
Hebei 38
Orem 37
Toronto 36
Paris 35
Da Nang 34
Naples 33
Redwood City 32
Tianjin 31
Chennai 30
Brussels 29
Catania 29
Nanchang 29
Nuremberg 29
Munich 28
Mexico City 27
Partanna 27
Vienna 27
Barcelona 26
Warsaw 26
Zhengzhou 26
Guangzhou 25
Montreal 25
Tashkent 25
Bremen 24
Jiaxing 24
Denver 23
Mumbai 23
Rio de Janeiro 23
Stockholm 23
Belo Horizonte 22
Corciano 22
Napoli 21
Quito 21
Tel Aviv 21
Washington 21
Birmingham 20
Johannesburg 20
Lappeenranta 20
Perugia 20
Ha Kwai Chung 19
Istanbul 19
Totale 14.611
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Nome #
Deciphering the Nonsense Readthrough Mechanism of Action of Ataluren: An in Silico Compared Study 335
In vitro and in silico studies of polycondensed diazine systems as anti-parasitic agents 306
Inhibition of FTSJ1, a tryptophan tRNA-specific 2’-O-methyltransferase as possible mechanism to readthrough premature termination codons (UGAs) of the CFTR mRNA 304
A Multivariate Analysis of HIV-1 Protease Inhibitors and Resistance Induced by Mutation 296
P015 Translational readthrough inducing drugs: a study of toxicity in mice models and in vitro safety validation of the specific readthrough process. 295
3D-QSAR Pharmacophore Modeling and in Silico Screening of new Bcl-xl Inhibitors 281
A comprehensive computational analysis of NR2F2/6 receptors for drug repurposing 275
Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies 255
A3 adenosine receptor: Homology modeling and 3D-QSAR studies 251
Does ligand symmetry play a role in the stabilization of DNA g-quadruplex host-guest complexes? 247
A multivariate analysis on HIV-1 protease inhibitors and resistance induced by mutation 246
A multivariate analysis on non-nucleoside HIV-1 reverse transcriptase inhibitors and resistance induced by mutation 246
Molecular Dynamics studies on Mdm2 complexes: an analysis of the inhibitor influence 243
Uno studio comparativo in silico sui possibili target di Ataluren e analoghi farmaci promotori di readthrough di codoni di stop prematuri 243
Derivati Ossadiazolici per il trattamento della fibrosi cistica: Readthrough di mutazioni nonsense 242
Trans-epithelial transport of the betalain pigments indicaxanthin and betanin across Caco-2 cell monolayers and influence of food matrix 238
A3 Adenosine Receptor: homology modeling and 3D-QSAR studies 237
Receptor-guided 3D-QSAR approach for the discovery of c-kit tyrosine kinase inhibitors 236
A QSAR study investigating the potential anti-HIV-1 effect of some Acyclovir and Ganciclovir analogs 231
Studies on a new potential dopaminergic agent: in vitro BBB permeability, in vivo behavioural effects and molecular docking evaluation 230
Molecular modelling and QSAR in the discovery of HIV-1 integrase inhibitors 229
Indicaxanthin from Opuntia ficus-indica Crosses the Blood−Brain Barrier and Modulates Neuronal Bioelectric Activity in Rat Hippocampus at Dietary-Consistent Amounts. 226
Pharmacophore-Based Design of New Chemical Scaffolds as Translational Readthrough-Inducing Drugs (TRIDs) 226
Phytochemical Indicaxanthin Inhibits Colon Cancer Cell Growth and Affects the DNA Methylation Status by Influencing Epigenetically Modifying Enzyme Expression and Activity 222
Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) 218
Nonsense codons suppression. An acute toxicity study of three optimized TRIDs in murine model, safety and tolerability evaluation 216
Biophysical characterization of MMACHC mutants: towards targeted therapies for the vitamin B12 metabolism disorder cblC 216
Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs 216
Predicting Skin Permeability by Means of Computational Approaches: Reliability and Caveats in Pharmaceutical Studies 214
FTSJ1 INHIBITION AS A STRATEGY FOR NONSENSE MUTATION SUPPRESSION IN TP53: INTEGRATIVE COMPUTATIONAL AND EXPERIMENTAL ANALYSIS 213
Theoretical Determination of the pK a Values of Betalamic Acid Related to the Free Radical Scavenger Capacity: Comparison Between Empirical and Quantum Chemical Methods 213
Micelles of the chiral biocompatible surfactant (1R,2S)-dodecyl-(2-hydroxy-1-methyl-2-phenylethyl)dimethylammonium bromide (DMEB): Molecular dynamics and fragmentation patterns in the gas phase 211
Molecular Modelling on Leptin and the Ob Receptor as anti-obesity target 209
Pharmacophore modelling as useful tool in the lead compounds identification and optimization 207
RESTORING MMACHC EXPRESSION: TRIDs AS A PROMISING APPROACH FOR cblC DEFICIENCY TREATMENT 205
NEW TRANSLATIONAL READTHROUGH INDUCING DRUGS RESCUING NONSENSE MUTATED TP53: STRATEGIES AGAINST CANCER 204
Study of the role of “gatekeeper” mutations V654A and T670I of c-kit kinase in the interaction with inhibitors by means mixed molecular dynamics/docking approach 204
Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening 203
Exploring the SARS-CoV-2 proteome in the search of potential inhibitors via structure-based pharmacophore modeling/docking approach 203
Promoting readthrough of nonsense mutations in CF mouse model: Biodistribution and efficacy of NV848 in rescuing CFTR protein expression 202
A Molecular Dynamics-Shared Pharmacophore Approach to Boost Early-Enrichment Virtual Screening: A Case Study on Peroxisome Proliferator-Activated Receptor α 202
Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution evaluation in mice models 199
In-silico screening of new potential Bcl-2/Bcl-xl inhibitors as apoptosis modulators 199
IKK-beta inhibitors: An analysis of drug–receptor interaction by using Molecular Docking and Pharmacophore 3D-QSAR approaches 197
Design, synthesis and preliminary evaluation of dopamine-amino acid conjugates as potential D1 dopaminergic modulators 197
Bcl-2 come target di farmaci antitumorali modulatori dell'apoptosi 191
Conf-VLKA: A structure-based revisitation of the Virtual Lock-and-key Approach 191
IN THE SEARCH OF LEPTIN AGONISTS AS ANTI-OBESITY DRUGS: PROTEIN/PROTEIN DOCKING, MOLECULAR DYNAMICS, AND VIRTUAL SCREENING 191
Targeting nonsense: Optimization of 1,2,4-oxadiazole trids to rescue cftr expression and functionality in cystic fibrosis cell model systems 190
Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells 188
INVESTIGATION ON MMACHC-R161Q PATHOLOGICAL MUTANT FROM cblC DISEASE, A RARE METABOLIC DISORDER OF VITAMIN B12 METABOLISM 188
Micelles, Rods, Liposomes, and Other Supramolecular Surfactant Aggregates: Computational Approaches 187
Chaperoning system: Intriguing target to modulate the expression of CFTR in cystic fibrosis 186
DA-Phen, a new dopamine aminoacid conjugate: in vivo testing and molecular modeling as dopaminergic modulator 185
INVESTIGATING THE NR2F2 STRUCTURE FOR DRUG REPURPOSING 184
Potential translational readthough inducin drugs: an optimized design and synthesis of new chemical scaffolds 184
A definitive pharmacophore modelling study on CDK2 ATP pocket binders: Tracing the path of new virtual high-throughput screenings 184
METODI CHEMIOMETRICI NELLO STUDIO DEGLI INIBITORI DI HIV-1: TECNICHE STATITICHE MULTIVARIATE E MOLECULAR DOCKING 180
Investigating the inhibition of FTSJ1 a tryptophan tRNA-specific 2’-O-methyltransferase by NV TRIDs, as a mechanism of readthrough in nonsense mutated CFTR 175
DOCKING AND MULTIVARIATE METHODS TO EXPLORE HIV-1 DRUG-RESISTANCE: A COMPARATIVE ANALYSIS 175
Investigation on MMACHC-R161Q pathological mutant from cblC disease 173
Phytol and heptacosane: the two major components of Euphorbia intisy essential oil with biological activities in drug resistant leukemia cell. 173
Readthrough Inducing Drugs (TRIDs) in human fibroblasts harboring the c.5047 C>T (R1683*) nonsense mutation 171
Analisi Multivariata e Docking nello Studio degli Inibitori di HIV-1 Integrasi 170
Design of small molecules and identification of putative anticancer therapeutic targets via in silico tools 169
Molecular Modeling Approaches in the Discovery of New Drugs for Anti-Cancer Therapy: The Investigation of p53-MDM2 Interaction and its Inhibition by Small Molecules 169
RESCUING P53 BY NEW TRANSLATIONAL READTHROUGH INDUCING DRUGS 168
Design of new DNA-interactive agents by molecular docking and QSPR approach 166
Multivariate analysis in the identification of biological targets for designed molecular structures: The BIOTA protocol 164
In Vitro Modulation of P-Glycoprotein Activity by Euphorbia intisy Essential Oil on Acute Myeloid Leukemia Cell Line HL-60R 164
Virtual lock-and-key approach: The in silico revival of Fischer model by means of molecular descriptors 163
Molecular dynamics, dynamic site mapping, and highthroughput virtual screening on leptin and the Ob receptor as anti-obesity target 163
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells 162
Recent advances on CDK inhibitors: An insight by means of in silico methods 162
CHA on CDK2: a way to identify the best pharmacophore model for the virtual screening of new inhibitors 158
Inside c-kit tyrosine kinase: molecular modeling and QSAR in the search of new inhibitors 157
A dynamic-common pharmacophore approach to improve virtual screening. A case study on PPAR-alpha 157
Identification of New Translational Readthrough Inducing Drugs 156
HIV-1 Protease Inhibitors and Resistance Induced by Mutation. Correlation between Multivariate Analysis and Molecular Docking. 154
Studio del ruolo delle mutazioni “gatekeeper” V654A e T670I di c-kit kinase nell’interazione con inibitori attraverso un approccio misto Dinamica Molecolare/Docking 154
Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs 154
Aminoquinolines: Fluorescent sensors to DNA – A minor groove probe. Experimental and in silico studies 151
Unlocking Cellular Secrets: Charting Proteomic Frontiers in LRBA Deficiency Through the Lens of Readthrough Promoters 150
The discovery of new inhibitors of HIF-1 transcriptional activity by virtual screening 150
CFTR G542X/ G542X mouse model carrying nonsense mutations, useful tool to test the efficacy of translational readthrough-based therapy in Cystic Fibrosis 149
A Fragile Protein Strengthened by Vitamin Intake, a Simulation Study of the Mmachc 149
TECNICHE DI MODELLISTICA MOLECOLARE NELLA PROGETTAZIONE DI INIBITORI DELL'ATTIVITÀ TRASCRIZIONALE DI HIF-1 149
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the readthrough of PTCs in CF cells 148
In vitro and in silico studies of polycondensed diazine systems as anti-infective agents 147
A dynamic multiple receptor conformations (MD-MRC) approach to enhance early enrichment in virtual screening. A case study on PPAR-alpha 147
Leptin and the ob-receptor as anti-obesity target: recent in silico advances in the comprehension of the protein-protein interaction and rational drug design of anti-obesity lead compounds 145
Natural products as non-covalent and covalent modulators of the KEAP1/NRF2 pathway exerting antioxidant effects 144
QSAR and molecular docking techniques in the study of HIV-1 inhibitors 142
A precision medicine approach to primary immunodeficiency disease: Ataluren strikes nonsense mutations once again 141
Identification of a new molecule with readthrough activity to rescue CFTR protein function 141
Studi di dinamica molecolare su Mdm2 legata a due differenti inibitori 140
Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells 140
Comparing molecular dynamics-derived pharmacophore models with docking: A study on CDK-2 inhibitors 139
Evaluation of the IKKβ Binding of Indicaxanthin by Induced-Fit Docking, Binding Pose Metadynamics, and Molecular Dynamics 139
Sulfonamide moiety as "molecular chimera" in the design of new drugs 135
Totale 19.440
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Categoria #
all - tutte 84.850
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 84.850
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022960 0 0 0 34 21 61 58 86 150 160 94 296
2022/20231.828 202 220 49 239 208 273 102 138 171 47 101 78
2023/20241.261 75 137 57 64 112 192 143 115 22 80 63 201
2024/20253.418 136 135 162 359 160 197 203 327 229 418 367 725
2025/202610.316 713 305 691 975 889 1.377 1.547 1.064 823 1.027 429 476
2026/20272.521 601 377 1.500 43 0 0 0 0 0 0 0 0
Totale 26.471