Archivio istituzionale della ricerca dell'Università degli Studi di Palermo

TUTONE, Marco
 Distribuzione geografica
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Continente #
NA - Nord America 9.614
EU - Europa 6.961
AS - Asia 5.551
SA - Sud America 983
AF - Africa 224
OC - Oceania 27
Continente sconosciuto - Info sul continente non disponibili 18
Totale 23.378
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Nazione #
US - Stati Uniti d'America 9.373
IT - Italia 2.305
SG - Singapore 1.697
RU - Federazione Russa 1.603
CN - Cina 1.421
BR - Brasile 721
VN - Vietnam 548
HK - Hong Kong 514
FI - Finlandia 483
DE - Germania 476
PL - Polonia 352
FR - Francia 339
UA - Ucraina 323
JP - Giappone 284
GB - Regno Unito 271
IN - India 249
IE - Irlanda 239
BD - Bangladesh 186
NL - Olanda 125
KR - Corea 122
MX - Messico 91
CA - Canada 90
ES - Italia 89
AR - Argentina 84
TR - Turchia 74
AT - Austria 71
SE - Svezia 70
IQ - Iraq 67
CI - Costa d'Avorio 66
BE - Belgio 45
IR - Iran 44
PK - Pakistan 44
ZA - Sudafrica 44
ID - Indonesia 42
EC - Ecuador 41
RO - Romania 38
UZ - Uzbekistan 37
IL - Israele 31
VE - Venezuela 30
CH - Svizzera 29
CL - Cile 29
AU - Australia 27
CO - Colombia 26
PY - Paraguay 26
DZ - Algeria 25
SA - Arabia Saudita 23
MA - Marocco 22
MY - Malesia 22
PT - Portogallo 22
EG - Egitto 20
JM - Giamaica 18
CZ - Repubblica Ceca 15
JO - Giordania 14
NP - Nepal 14
PH - Filippine 14
BG - Bulgaria 13
TN - Tunisia 13
TW - Taiwan 13
XK - ???statistics.table.value.countryCode.XK??? 13
AE - Emirati Arabi Uniti 11
GR - Grecia 10
LT - Lituania 10
PE - Perù 10
KZ - Kazakistan 9
BO - Bolivia 8
LB - Libano 8
NG - Nigeria 8
SY - Repubblica araba siriana 8
BH - Bahrain 7
CR - Costa Rica 7
PA - Panama 7
TH - Thailandia 7
UY - Uruguay 7
AL - Albania 6
KE - Kenya 6
DK - Danimarca 5
HN - Honduras 5
QA - Qatar 5
BY - Bielorussia 4
ET - Etiopia 4
GE - Georgia 4
KH - Cambogia 4
LK - Sri Lanka 4
NO - Norvegia 4
PS - Palestinian Territory 4
AZ - Azerbaigian 3
BB - Barbados 3
BN - Brunei Darussalam 3
DO - Repubblica Dominicana 3
EU - Europa 3
OM - Oman 3
PR - Porto Rico 3
RS - Serbia 3
TT - Trinidad e Tobago 3
AM - Armenia 2
BS - Bahamas 2
CY - Cipro 2
GA - Gabon 2
KG - Kirghizistan 2
KW - Kuwait 2
Totale 23.338
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Città #
Ashburn 1.186
Singapore 1.133
San Jose 872
Palermo 817
Fairfield 751
Hong Kong 473
Chandler 463
Woodbridge 418
Houston 393
Ann Arbor 349
Wilmington 336
Zgierz 312
Seattle 301
Cambridge 260
Moscow 254
Dublin 233
Tokyo 223
Beijing 220
Council Bluffs 215
Ho Chi Minh City 207
Medford 163
Jacksonville 160
Los Angeles 150
Dallas 146
Helsinki 146
New York 143
Lauterbourg 142
Santa Clara 128
Nanjing 121
Hanoi 114
Frankfurt am Main 113
Hefei 110
Princeton 107
Rome 101
Boardman 96
Milan 90
Des Moines 81
The Dalles 81
Buffalo 74
Altamura 67
Abidjan 65
São Paulo 63
Hyderabad 62
San Diego 56
Dearborn 55
Lawrence 51
London 50
Tulsa 46
Shenyang 45
Jinan 44
Chicago 42
Amsterdam 41
Columbus 41
Ludwigshafen am Rhein 40
Philadelphia 40
Changsha 38
Hebei 38
Orem 35
Paris 35
Da Nang 34
Redwood City 32
Tianjin 31
Atlanta 30
Chennai 30
Brussels 29
Nanchang 29
Munich 28
Nuremberg 28
Brooklyn 27
Partanna 27
Vienna 27
Barcelona 26
Zhengzhou 26
Guangzhou 25
Naples 25
Tashkent 25
Jiaxing 24
Warsaw 24
Bremen 23
Catania 23
Mexico City 23
Phoenix 23
Rio de Janeiro 23
Corciano 22
Mumbai 21
Napoli 21
Tel Aviv 21
Belo Horizonte 20
Johannesburg 20
Lappeenranta 20
Perugia 20
Ha Kwai Chung 19
Istanbul 19
Redondo Beach 19
Toronto 19
Birmingham 18
Haiphong 18
Montreal 18
Stockholm 18
Washington 18
Totale 13.609
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Nome #
Deciphering the Nonsense Readthrough Mechanism of Action of Ataluren: An in Silico Compared Study 323
Inhibition of FTSJ1, a tryptophan tRNA-specific 2’-O-methyltransferase as possible mechanism to readthrough premature termination codons (UGAs) of the CFTR mRNA 294
In vitro and in silico studies of polycondensed diazine systems as anti-parasitic agents 289
P015 Translational readthrough inducing drugs: a study of toxicity in mice models and in vitro safety validation of the specific readthrough process. 282
A Multivariate Analysis of HIV-1 Protease Inhibitors and Resistance Induced by Mutation 280
3D-QSAR Pharmacophore Modeling and in Silico Screening of new Bcl-xl Inhibitors 261
Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies 246
A comprehensive computational analysis of NR2F2/6 receptors for drug repurposing 245
A3 adenosine receptor: Homology modeling and 3D-QSAR studies 239
A multivariate analysis on HIV-1 protease inhibitors and resistance induced by mutation 235
A multivariate analysis on non-nucleoside HIV-1 reverse transcriptase inhibitors and resistance induced by mutation 235
Uno studio comparativo in silico sui possibili target di Ataluren e analoghi farmaci promotori di readthrough di codoni di stop prematuri 231
Derivati Ossadiazolici per il trattamento della fibrosi cistica: Readthrough di mutazioni nonsense 228
Molecular Dynamics studies on Mdm2 complexes: an analysis of the inhibitor influence 226
Does ligand symmetry play a role in the stabilization of DNA g-quadruplex host-guest complexes? 226
Receptor-guided 3D-QSAR approach for the discovery of c-kit tyrosine kinase inhibitors 223
Trans-epithelial transport of the betalain pigments indicaxanthin and betanin across Caco-2 cell monolayers and influence of food matrix 222
Studies on a new potential dopaminergic agent: in vitro BBB permeability, in vivo behavioural effects and molecular docking evaluation 221
Molecular modelling and QSAR in the discovery of HIV-1 integrase inhibitors 217
A3 Adenosine Receptor: homology modeling and 3D-QSAR studies 217
A QSAR study investigating the potential anti-HIV-1 effect of some Acyclovir and Ganciclovir analogs 216
Phytochemical Indicaxanthin Inhibits Colon Cancer Cell Growth and Affects the DNA Methylation Status by Influencing Epigenetically Modifying Enzyme Expression and Activity 212
Indicaxanthin from Opuntia ficus-indica Crosses the Blood−Brain Barrier and Modulates Neuronal Bioelectric Activity in Rat Hippocampus at Dietary-Consistent Amounts. 211
Nonsense codons suppression. An acute toxicity study of three optimized TRIDs in murine model, safety and tolerability evaluation 209
Predicting Skin Permeability by Means of Computational Approaches: Reliability and Caveats in Pharmaceutical Studies 207
Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) 205
Theoretical Determination of the pK a Values of Betalamic Acid Related to the Free Radical Scavenger Capacity: Comparison Between Empirical and Quantum Chemical Methods 204
Micelles of the chiral biocompatible surfactant (1R,2S)-dodecyl-(2-hydroxy-1-methyl-2-phenylethyl)dimethylammonium bromide (DMEB): Molecular dynamics and fragmentation patterns in the gas phase 204
Biophysical characterization of MMACHC mutants: towards targeted therapies for the vitamin B12 metabolism disorder cblC 202
Molecular Modelling on Leptin and the Ob Receptor as anti-obesity target 201
Pharmacophore-Based Design of New Chemical Scaffolds as Translational Readthrough-Inducing Drugs (TRIDs) 200
Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening 199
Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs 197
FTSJ1 INHIBITION AS A STRATEGY FOR NONSENSE MUTATION SUPPRESSION IN TP53: INTEGRATIVE COMPUTATIONAL AND EXPERIMENTAL ANALYSIS 196
Pharmacophore modelling as useful tool in the lead compounds identification and optimization 196
Exploring the SARS-CoV-2 proteome in the search of potential inhibitors via structure-based pharmacophore modeling/docking approach 196
A Molecular Dynamics-Shared Pharmacophore Approach to Boost Early-Enrichment Virtual Screening: A Case Study on Peroxisome Proliferator-Activated Receptor α 195
RESTORING MMACHC EXPRESSION: TRIDs AS A PROMISING APPROACH FOR cblC DEFICIENCY TREATMENT 194
Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution evaluation in mice models 189
Study of the role of “gatekeeper” mutations V654A and T670I of c-kit kinase in the interaction with inhibitors by means mixed molecular dynamics/docking approach 188
NEW TRANSLATIONAL READTHROUGH INDUCING DRUGS RESCUING NONSENSE MUTATED TP53: STRATEGIES AGAINST CANCER 187
Design, synthesis and preliminary evaluation of dopamine-amino acid conjugates as potential D1 dopaminergic modulators 187
In-silico screening of new potential Bcl-2/Bcl-xl inhibitors as apoptosis modulators 187
Micelles, Rods, Liposomes, and Other Supramolecular Surfactant Aggregates: Computational Approaches 181
IKK-beta inhibitors: An analysis of drug–receptor interaction by using Molecular Docking and Pharmacophore 3D-QSAR approaches 180
Targeting nonsense: Optimization of 1,2,4-oxadiazole trids to rescue cftr expression and functionality in cystic fibrosis cell model systems 180
INVESTIGATION ON MMACHC-R161Q PATHOLOGICAL MUTANT FROM cblC DISEASE, A RARE METABOLIC DISORDER OF VITAMIN B12 METABOLISM 180
Conf-VLKA: A structure-based revisitation of the Virtual Lock-and-key Approach 179
IN THE SEARCH OF LEPTIN AGONISTS AS ANTI-OBESITY DRUGS: PROTEIN/PROTEIN DOCKING, MOLECULAR DYNAMICS, AND VIRTUAL SCREENING 178
Promoting readthrough of nonsense mutations in CF mouse model: Biodistribution and efficacy of NV848 in rescuing CFTR protein expression 177
Potential translational readthough inducin drugs: an optimized design and synthesis of new chemical scaffolds 176
Bcl-2 come target di farmaci antitumorali modulatori dell'apoptosi 173
A definitive pharmacophore modelling study on CDK2 ATP pocket binders: Tracing the path of new virtual high-throughput screenings 173
Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells 171
INVESTIGATING THE NR2F2 STRUCTURE FOR DRUG REPURPOSING 167
Investigating the inhibition of FTSJ1 a tryptophan tRNA-specific 2’-O-methyltransferase by NV TRIDs, as a mechanism of readthrough in nonsense mutated CFTR 165
Readthrough Inducing Drugs (TRIDs) in human fibroblasts harboring the c.5047 C>T (R1683*) nonsense mutation 165
DOCKING AND MULTIVARIATE METHODS TO EXPLORE HIV-1 DRUG-RESISTANCE: A COMPARATIVE ANALYSIS 164
METODI CHEMIOMETRICI NELLO STUDIO DEGLI INIBITORI DI HIV-1: TECNICHE STATITICHE MULTIVARIATE E MOLECULAR DOCKING 164
DA-Phen, a new dopamine aminoacid conjugate: in vivo testing and molecular modeling as dopaminergic modulator 164
Phytol and heptacosane: the two major components of Euphorbia intisy essential oil with biological activities in drug resistant leukemia cell. 164
Design of small molecules and identification of putative anticancer therapeutic targets via in silico tools 159
Analisi Multivariata e Docking nello Studio degli Inibitori di HIV-1 Integrasi 159
Investigation on MMACHC-R161Q pathological mutant from cblC disease 158
RESCUING P53 BY NEW TRANSLATIONAL READTHROUGH INDUCING DRUGS 157
Molecular Modeling Approaches in the Discovery of New Drugs for Anti-Cancer Therapy: The Investigation of p53-MDM2 Interaction and its Inhibition by Small Molecules 156
Virtual lock-and-key approach: The in silico revival of Fischer model by means of molecular descriptors 156
In Vitro Modulation of P-Glycoprotein Activity by Euphorbia intisy Essential Oil on Acute Myeloid Leukemia Cell Line HL-60R 156
Recent advances on CDK inhibitors: An insight by means of in silico methods 154
Design of new DNA-interactive agents by molecular docking and QSPR approach 153
Molecular dynamics, dynamic site mapping, and highthroughput virtual screening on leptin and the Ob receptor as anti-obesity target 153
Multivariate analysis in the identification of biological targets for designed molecular structures: The BIOTA protocol 151
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells 149
Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs 149
CHA on CDK2: a way to identify the best pharmacophore model for the virtual screening of new inhibitors 148
A dynamic-common pharmacophore approach to improve virtual screening. A case study on PPAR-alpha 146
CFTR G542X/ G542X mouse model carrying nonsense mutations, useful tool to test the efficacy of translational readthrough-based therapy in Cystic Fibrosis 142
Unlocking Cellular Secrets: Charting Proteomic Frontiers in LRBA Deficiency Through the Lens of Readthrough Promoters 142
Chaperoning system: Intriguing target to modulate the expression of CFTR in cystic fibrosis 141
Identification of New Translational Readthrough Inducing Drugs 141
Inside c-kit tyrosine kinase: molecular modeling and QSAR in the search of new inhibitors 141
TECNICHE DI MODELLISTICA MOLECOLARE NELLA PROGETTAZIONE DI INIBITORI DELL'ATTIVITÀ TRASCRIZIONALE DI HIF-1 140
Aminoquinolines: Fluorescent sensors to DNA – A minor groove probe. Experimental and in silico studies 140
A Fragile Protein Strengthened by Vitamin Intake, a Simulation Study of the Mmachc 139
The discovery of new inhibitors of HIF-1 transcriptional activity by virtual screening 138
A dynamic multiple receptor conformations (MD-MRC) approach to enhance early enrichment in virtual screening. A case study on PPAR-alpha 137
Natural products as non-covalent and covalent modulators of the KEAP1/NRF2 pathway exerting antioxidant effects 136
Studio del ruolo delle mutazioni “gatekeeper” V654A e T670I di c-kit kinase nell’interazione con inibitori attraverso un approccio misto Dinamica Molecolare/Docking 136
In vitro and in silico studies of polycondensed diazine systems as anti-infective agents 134
A precision medicine approach to primary immunodeficiency disease: Ataluren strikes nonsense mutations once again 133
QSAR and molecular docking techniques in the study of HIV-1 inhibitors 133
HIV-1 Protease Inhibitors and Resistance Induced by Mutation. Correlation between Multivariate Analysis and Molecular Docking. 133
Leptin and the ob-receptor as anti-obesity target: recent in silico advances in the comprehension of the protein-protein interaction and rational drug design of anti-obesity lead compounds 131
Evaluation of the IKKβ Binding of Indicaxanthin by Induced-Fit Docking, Binding Pose Metadynamics, and Molecular Dynamics 131
Studi di dinamica molecolare su Mdm2 legata a due differenti inibitori 130
Identification of a new molecule with readthrough activity to rescue CFTR protein function 129
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the readthrough of PTCs in CF cells 128
The in silico fischer lock-and-key model: The combined use of molecular descriptors and docking poses for the repurposing of old drugs 128
Investigation on quantitative structure-activity relationships of 1,3,4-oxadiazole derivatives as potential telomerase inhibitors 127
Sulfonamide moiety as "molecular chimera" in the design of new drugs 126
Totale 18.163
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Categoria #
all - tutte 79.106
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 79.106
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.316 90 236 30 34 21 61 58 86 150 160 94 296
2022/20231.828 202 220 49 239 208 273 102 138 171 47 101 78
2023/20241.261 75 137 57 64 112 192 143 115 22 80 63 201
2024/20253.418 136 135 162 359 160 197 203 327 229 418 367 725
2025/202610.316 713 305 691 975 889 1.377 1.547 1.064 823 1.027 429 476
2026/2027367 367 0 0 0 0 0 0 0 0 0 0 0
Totale 24.317