Parasitic diseases caused by protozoarian agents are still relevant today more than ever. Recently, we synthesized several polycondensed diazine derivatives by means 1,3-dipolar cycloaddition reactions. A broad selection of these compounds were submitted to in vitro biological screening against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei, and Trypanosoma cruzi, resulting active at micromolar level. Induced Fit Docking/MM-GBSA studies were performed giving interesting indications about the probable mechanism of action of the most active compounds

ALMERICO, A.M., TUTONE, M., GUARCELLO, A., LAURIA, A. (2012). In vitro and in silico studies of polycondensed diazine systems as anti-parasitic agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22, 1000-1004 [10.1016/j.bmcl.2011.12.004].

In vitro and in silico studies of polycondensed diazine systems as anti-parasitic agents

ALMERICO, Anna Maria;TUTONE, Marco;GUARCELLO, Annalisa;LAURIA, Antonino
2012-01-01

Abstract

Parasitic diseases caused by protozoarian agents are still relevant today more than ever. Recently, we synthesized several polycondensed diazine derivatives by means 1,3-dipolar cycloaddition reactions. A broad selection of these compounds were submitted to in vitro biological screening against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei, and Trypanosoma cruzi, resulting active at micromolar level. Induced Fit Docking/MM-GBSA studies were performed giving interesting indications about the probable mechanism of action of the most active compounds
2012
Settore CHIM/08 - Chimica Farmaceutica
ALMERICO, A.M., TUTONE, M., GUARCELLO, A., LAURIA, A. (2012). In vitro and in silico studies of polycondensed diazine systems as anti-parasitic agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22, 1000-1004 [10.1016/j.bmcl.2011.12.004].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/64913
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