Parasitic diseases caused by protozoarian agents are still relevant today more than ever. Recently, we synthesized several polycondensed diazine derivatives by means 1,3-dipolar cycloaddition reactions. A broad selection of these compounds were submitted to in vitro biological screening against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei, and Trypanosoma cruzi, resulting active at micromolar level. Induced Fit Docking/MM-GBSA studies were performed giving interesting indications about the probable mechanism of action of the most active compounds

ALMERICO, A.M., TUTONE, M., GUARCELLO, A., & LAURIA, A. (2012). In vitro and in silico studies of polycondensed diazine systems as anti-parasitic agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22, 1000-1004 [10.1016/j.bmcl.2011.12.004].

In vitro and in silico studies of polycondensed diazine systems as anti-parasitic agents

ALMERICO, Anna Maria;TUTONE, Marco;GUARCELLO, Annalisa;LAURIA, Antonino
2012

Abstract

Parasitic diseases caused by protozoarian agents are still relevant today more than ever. Recently, we synthesized several polycondensed diazine derivatives by means 1,3-dipolar cycloaddition reactions. A broad selection of these compounds were submitted to in vitro biological screening against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei, and Trypanosoma cruzi, resulting active at micromolar level. Induced Fit Docking/MM-GBSA studies were performed giving interesting indications about the probable mechanism of action of the most active compounds
Settore CHIM/08 - Chimica Farmaceutica
ALMERICO, A.M., TUTONE, M., GUARCELLO, A., & LAURIA, A. (2012). In vitro and in silico studies of polycondensed diazine systems as anti-parasitic agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22, 1000-1004 [10.1016/j.bmcl.2011.12.004].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/64913
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