Parasitic diseases caused by protozoarian agents are still relevant today more than ever. Recently, we synthesized several polycondensed diazine derivatives by means 1,3-dipolar cycloaddition reactions. A broad selection of these compounds were submitted to in vitro biological screening against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei, and Trypanosoma cruzi, resulting active at micromolar level. Induced Fit Docking/MM-GBSA studies were performed giving interesting indications about the probable mechanism of action of the most active compounds
ALMERICO, A.M., TUTONE, M., GUARCELLO, A., LAURIA, A. (2012). In vitro and in silico studies of polycondensed diazine systems as anti-parasitic agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22, 1000-1004 [10.1016/j.bmcl.2011.12.004].
In vitro and in silico studies of polycondensed diazine systems as anti-parasitic agents
ALMERICO, Anna Maria;TUTONE, Marco;GUARCELLO, Annalisa;LAURIA, Antonino
2012-01-01
Abstract
Parasitic diseases caused by protozoarian agents are still relevant today more than ever. Recently, we synthesized several polycondensed diazine derivatives by means 1,3-dipolar cycloaddition reactions. A broad selection of these compounds were submitted to in vitro biological screening against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei, and Trypanosoma cruzi, resulting active at micromolar level. Induced Fit Docking/MM-GBSA studies were performed giving interesting indications about the probable mechanism of action of the most active compounds
| File | Dimensione | Formato | |
|---|---|---|---|
|
12BMCL1000.pdf
accesso aperto
Dimensione
891.6 kB
Formato
Adobe PDF
|
891.6 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
