Over the latest years phytochemical consumption has been associated to a decreased risk of both theonset and the development of a number of pathological conditions. In this context indicaxanthin, abetalain pigment fromOpuntiaficus-indicafruit, has been the object of sound research. Explored, atfirst,for its mere antioxidant potential, Indicaxanthin is now regarded as a redox-active compound able toexert significant poly-pharmacological effects against several targets in a number of experimental con-ditions bothin vivoandin vitro. This paper aims to provide an overview on the therapeutical effects ofindicaxanthin, ranging from the anti-inflammatory to the neuro-modulatory and anti-tumoral ones andfavored by its high bioavailability. Moreover, biochemical and molecular modelling investigations areaimed to identify the pharmacological targets the compound is able to interact with and to address thechallenging development in the future research

Allegra, M., Tutone, M., Tesoriere, L., Almerico, A.M., Culletta, G., Livrea, M.A., et al. (2019). Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 179, 753-764 [10.1016/j.ejmech.2019.07.006].

Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies

Allegra, Mario;Tutone, Marco
;
Tesoriere, Luisa;Almerico, Anna Maria;Culletta, Giulia;Livrea, Maria Antonia;Attanzio, Alessandro
2019-01-01

Abstract

Over the latest years phytochemical consumption has been associated to a decreased risk of both theonset and the development of a number of pathological conditions. In this context indicaxanthin, abetalain pigment fromOpuntiaficus-indicafruit, has been the object of sound research. Explored, atfirst,for its mere antioxidant potential, Indicaxanthin is now regarded as a redox-active compound able toexert significant poly-pharmacological effects against several targets in a number of experimental con-ditions bothin vivoandin vitro. This paper aims to provide an overview on the therapeutical effects ofindicaxanthin, ranging from the anti-inflammatory to the neuro-modulatory and anti-tumoral ones andfavored by its high bioavailability. Moreover, biochemical and molecular modelling investigations areaimed to identify the pharmacological targets the compound is able to interact with and to address thechallenging development in the future research
2019
Settore BIO/10 - Biochimica
Settore CHIM/08 - Chimica Farmaceutica
Allegra, M., Tutone, M., Tesoriere, L., Almerico, A.M., Culletta, G., Livrea, M.A., et al. (2019). Indicaxanthin, a multi-target natural compound from Opuntia ficus-indica fruit: From its poly-pharmacological effects to biochemical mechanisms and molecular modelling studies. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 179, 753-764 [10.1016/j.ejmech.2019.07.006].
File in questo prodotto:
File Dimensione Formato  
European Journal of Medicinal Chemistry-main.pdf

Solo gestori archvio

Descrizione: Articolo principale
Tipologia: Versione Editoriale
Dimensione 1.06 MB
Formato Adobe PDF
1.06 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
pagination_EJMECH_11503.pdf

accesso aperto

Tipologia: Pre-print
Dimensione 1.12 MB
Formato Adobe PDF
1.12 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/368341
Citazioni
  • ???jsp.display-item.citation.pmc??? 13
  • Scopus 20
  • ???jsp.display-item.citation.isi??? 20
social impact