A QSAR study, involving the use of alculated physical-chemical properties (TSARTM), and the use of a neural network approach (TSARTM), has been performed on the potential anti-HIV-1 activity of a series of Acyclovir and Ganciclovir analogs. Model obtained allows reliable predictions for the anti-HIV-1 activity of these derivatives, and showed that the presence of the Ganciclovir chain in triazolopyrrolopyrimidine and pyrimidopyrrolopyrimidine series seems to increase the antiviral effect.
Almerico, A.M., Tutone, M., Lauria, A. (2009). A QSAR study investigating the potential anti-HIV-1 effect of some Acyclovir and Ganciclovir analogs. ARKIVOC, VIII, 85-94.
A QSAR study investigating the potential anti-HIV-1 effect of some Acyclovir and Ganciclovir analogs
ALMERICO, Anna Maria;TUTONE, Marco;LAURIA, Antonino
2009-01-01
Abstract
A QSAR study, involving the use of alculated physical-chemical properties (TSARTM), and the use of a neural network approach (TSARTM), has been performed on the potential anti-HIV-1 activity of a series of Acyclovir and Ganciclovir analogs. Model obtained allows reliable predictions for the anti-HIV-1 activity of these derivatives, and showed that the presence of the Ganciclovir chain in triazolopyrrolopyrimidine and pyrimidopyrrolopyrimidine series seems to increase the antiviral effect.File | Dimensione | Formato | |
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