Archivio istituzionale della ricerca dell'Università degli Studi di Palermo

DI LEONARDO, Aldo
 Distribuzione geografica
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Continente #
NA - Nord America 4.755
EU - Europa 2.916
AS - Asia 1.098
AF - Africa 61
SA - Sud America 22
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 4
Totale 8.868
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Nazione #
US - Stati Uniti d'America 4.735
IT - Italia 1.099
CN - Cina 523
UA - Ucraina 373
FI - Finlandia 369
SG - Singapore 324
DE - Germania 294
IE - Irlanda 182
GB - Regno Unito 162
SE - Svezia 139
IN - India 124
FR - Francia 70
RU - Federazione Russa 63
CI - Costa d'Avorio 54
BE - Belgio 40
NL - Olanda 39
JP - Giappone 36
TR - Turchia 26
RO - Romania 22
KR - Corea 21
ES - Italia 16
HK - Hong Kong 15
CA - Canada 14
PL - Polonia 11
AU - Australia 10
GR - Grecia 9
BR - Brasile 8
CL - Cile 8
CH - Svizzera 7
AT - Austria 6
MX - Messico 6
DK - Danimarca 5
IL - Israele 5
PK - Pakistan 5
CO - Colombia 4
UZ - Uzbekistan 4
DZ - Algeria 3
IR - Iran 3
MY - Malesia 3
SK - Slovacchia (Repubblica Slovacca) 3
MA - Marocco 2
NO - Norvegia 2
NZ - Nuova Zelanda 2
PT - Portogallo 2
TW - Taiwan 2
UY - Uruguay 2
VN - Vietnam 2
XK - ???statistics.table.value.countryCode.XK??? 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AE - Emirati Arabi Uniti 1
BG - Bulgaria 1
CZ - Repubblica Ceca 1
EU - Europa 1
ID - Indonesia 1
LB - Libano 1
MD - Moldavia 1
PS - Palestinian Territory 1
TH - Thailandia 1
TN - Tunisia 1
ZA - Sudafrica 1
Totale 8.868
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Città #
Fairfield 598
Ashburn 426
Chandler 395
Palermo 365
Ann Arbor 318
Woodbridge 315
Houston 286
Wilmington 281
Singapore 267
Jacksonville 203
Seattle 203
Cambridge 189
Dublin 181
Medford 149
Des Moines 106
Nanjing 97
Princeton 94
Hyderabad 87
Bremen 82
Boardman 64
Tulsa 56
Abidjan 54
Altamura 53
Helsinki 50
Milan 50
Beijing 49
San Diego 45
Dearborn 41
Shenyang 38
Lawrence 37
Changsha 36
Jinan 36
Ludwigshafen am Rhein 34
New York 31
Santa Clara 31
Brussels 29
Nanchang 29
Hebei 28
Düsseldorf 27
Tianjin 27
Rome 26
Jiaxing 25
Venice 24
London 23
Ningbo 22
Redwood City 21
Izmir 20
Paris 20
Los Angeles 17
Philadelphia 17
Verona 17
Chikmagalūr 16
Seongnam 16
Saint Petersburg 15
Bacoli 13
Haikou 13
Amsterdam 12
Guangzhou 12
Kumar 12
Phoenix 12
Volturara Irpina 12
Taizhou 11
Tokyo 11
Barcelona 10
Columbus 10
Edinburgh 10
Naples 10
San Paolo di Civitate 10
Zhengzhou 10
Washington 9
Apeldoorn 8
Kunming 8
Baltimore 7
Bristol 7
Lanzhou 7
San Mateo 7
Trapani 7
Alcamo 6
Carovigno 6
Frankfurt am Main 6
Hong Kong 6
Kilburn 6
Orange 6
Redmond 6
Taiyuan 6
Turin 6
Carini 5
Catania 5
Dallas 5
Flower Mound 5
Frankfurt 5
Fuzhou 5
Norwalk 5
Rawalpindi 5
Shanghai 5
Tappahannock 5
Berlin 4
Birmingham 4
Cali 4
Chicago 4
Totale 6.114
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Nome #
Caffeine boosts Ataluren's readthrough activity 189
Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives 187
Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay 184
Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells 183
Retinoblastoma epidemiology: Does the evidence matter? 175
CENPA overexpression promotes genome instability in pRb-depleted human cells. 175
Inhibition of FTSJ1, a tryptophan tRNA-specific 2’-O-methyltransferase as possible mechanism to readthrough premature termination codons (UGAs) of the CFTR mRNA 173
Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype 163
P015 Translational readthrough inducing drugs: a study of toxicity in mice models and in vitro safety validation of the specific readthrough process. 163
p14(ARF) Prevents Proliferation of Aneuploid Cells by Inducing p53-Dependent Apoptosis 160
Investigating CRISPR-CAS13b as a tool for the RNA editing of CFTR mRNA with premature stop codon 157
Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening 156
NOTCH3 expression is linked to breast cancer seeding and distant metastasis 148
Expression of the kinetochore protein Hec1 during the cell cycle in normal and cancer cells and its regulation by the pRb pathway. 145
Derivati Ossadiazolici per il trattamento della fibrosi cistica: Readthrough di mutazioni nonsense 140
Aurora-A transcriptional silencing and Vincristine treatment show a synergistic effect in human tumor cells 139
Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs 139
AZIONE READTHROUGH DI DERIVATI DEL PTC124 SU SISTEMI MODELLO CELLULARI E IN CELLULE DI EPITELIO BRONCHIALE-FC IB3.1 (CFTR F508/W1282X ) 132
Targeting nonsense: Optimization of 1,2,4-oxadiazole trids to rescue cftr expression and functionality in cystic fibrosis cell model systems 130
MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a P53 pathway preventing aneuploid cells propagation. 128
Functional inactivation of pRB results in aneuploid mammalian cells after release from a mitotic block 128
DNA demethylation caused By 5-Aza-2'-Deoxycytidine induces mitotic alterations and aneuploidy 126
RNAi mediated acute depletion of Retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation 125
P14ARF: The absence that makes the difference 123
Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts 122
Proliferation of aneuploid cells induced by CENP-E depletion is counteracted by the p14ARFtumor suppressor 122
Simultaneous reduction of MAD2 and BUBR1 expression induces mitotic spindle alterations associated with p53 dependent cell cycle arrest and death 120
Does the evidence matter in medicine? The retinoblastoma paradigm. 117
Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) 117
RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts 116
Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons 116
The sea urchin sns insulator blocks CMV enhancer following integration in human cells 114
Premature termination codon 124 derivatives as a novel approach to improve the read-through of premature amber and ochre stop codons 112
Aneuploid IMR90 cells induced by depletion of pRB, DNMT1 and MAD2 show a common gene expression signature 108
DNMT1 depletion activates a pathway p14ARF/TP53 controlled that induces G1 arrest preventing DNA demethylation and aneuploidy 107
Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells 106
PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene. 105
The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. 99
Low doses of Hydroxyurea induce centrosome amplification and aneuploidy in primary human fibroblasts in culture 93
Micronuclei generation and chromosomal instability after RB interferences in human fibroblasts 92
Acute loss of pRB function induces centrosome amplification and aneuploidy both in murine and human fibroblasts 90
Chromosomal instability promoted by RB depletion relied neither on p53 nor SAC dysfunction in HCT116 tumor cells 87
Aurora-A/STK15 transcriptional silencing and Vincristine treatment show a synergistic effect in human tumour cells 86
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells 86
Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs 85
PTC124 DERIVATIVES AS A NOVEL APPROACH TO IMPROVE THE READTHROUGH OF PREMATURE AMBER AND OCHRE STOP CODONS 82
Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution evaluation in mice models 81
Acute loss of pRB function induces centrosome amplification and aneuploidy in human fibroblasts 81
Identification of a new molecule with readthrough activity to rescue CFTR protein function 80
Acute loss of retinoblastoma function induces centrosomes amplification both in murine and human fibroblasts 79
AURKA (aurora kinase A) 78
Aneuploidy induced by MAD2 haploinsufficiency triggers premature senescence in human primary fibroblast 77
Inhalable nano into micro dry powders for ivacaftor delivery: the role of mannitol and cysteamine as mucus-active agents 77
Aneuploidia e alterazione dei centrosomi in MEF pRb deficienti. 76
Acute loss of retinoblastoma function induces centrosome amplification and aneuploidy both in human and murine primary fibroblasts 76
Gene amplification in fibroblasts from ataxia telangiectasia (AT) patients and in X-ray hypersensitive AT-like Chinese hamster mutants 74
Nonsense codons suppression. An acute toxicity study of three optimized TRIDs in murine model, safety and tolerability evaluation 73
Aurora A overexpression leads centrosome amplification and aneuploidy in human colon cancer cells with MIN phenotype 73
Bypass of G1 arrest induced by DNMT1 posttranscriptional silencing triggers aneuploidy in human cells. 73
X CONVENTION OF INVESTIGATORS IN CYSTIC FIBROSIS. 73
EFFECTS OF PLK1 DEPLETION IN CENTROSOME DUPLICATIONS AND CELL CYCLEPROGRESSION IN HCT116 TUMOR CELLS. 72
DNA Methyltransferase1 post-transcriptional silencing induces aneuploidy and cell cycle arrest in human cells. 72
Acute loss of pRb induces centrosome amplification and aneuploidy both in human and murine primary fibroblasts 71
RNA Editing Approaches for the correction of nonsense mutation in a cell model for Cystic Fibrosis 70
DNMT1 transient silencing induces aneuploidy, premature separated chromatids and centromeric chromatin alterations 69
Identification of pathways involved in aneuploidy onset and its tolerance using a DNA microarray approach 68
Hydroxyurea induces centrosome amplification and slowing down of cell cycle in colo-cancer cells SW480 67
Global DNA Hypomethylation following 5-aza-2'-deoxycytidine treatment induces aneuploidy in HCT-116 tumor cells. 67
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the readthrough of PTCs in CF cells 65
Effetti del Silenziamento dei geni Plk1, Brca1 e Rb nella duplicazione dei centrosomi in cellule tumorali HCT116 64
Missing evidences in cancer genetics: The retinoblastoma paradigm. 64
Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells 64
Silencing of serine threonine kinase Aurora-2 gene cause G2/M arrest and apotosis in human carcinoma lung large cells 63
Silencing of serine threonine kinase Aurora-2 gene causes G2/M arrest and apoptosis in human carcinoma lung large cells. 63
“DNA Methyl transferase 1 post-trascriptional silencing indues aneuploidy and cell cycle arrest in human cells”, 62
Transient and stable depletion of RB induce different expression of genes involved in epigenetic modifications. 60
Transcriptomic changes following partial depletion of cenp‐e in normal human fibroblasts 60
Effects of Plk1 depletion on centrosome duplication and cell cycle progression in HCT116 tumor cells 59
Transient silencing of MAD2 induces mitotic abnormalities and p21waf1 overexpression in primary human fibroblasts 59
PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene 59
STK15 overexpression in HCT116 cells causes mitotic disorders and hypodiploidy associated with centrosome amplification. 58
Hydroxiurea induces centrosome amplification and slowing down of cell cycle in colo-cancer cells SW480 58
Effetti del silenziamento dei geni Plk1, Brca1 ed Rb nella duplicazione dei centrosomi in cellule tumorali HCT116 57
RB acute loss affects expression of mitotic genes and is associated with centrosome amplification and aneuploidy 56
RNA interference of MAD2 and BUBR1 genes causes mitotic spindle alterations, aneuploidy and cell cycle arrest p53-dependent. 56
pRb loss and chromosomal instability in human cells. 56
Identification of mechanism(s) leading to hyperdiploidy in progenitor tumor cells derived from MCF7 breast cancer cells 56
The retinoblastoma paradigm revisited 55
Identification of pathways involved in aneuploidy onset and its tolerance using a DNA microarray approach 55
The tumor suppressor p14ARF hampers proliferation of aneuploid cells induced by CENP-E partial depletion 53
OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS 51
Pyrazole[3,4-d]pyrimidine derivatives loaded into halloysite as potential CDK inhibitors 51
Chromosome Instability, friend or foe: genetic and epigenetic causes in cancer 49
Rb depletion induces centrosome amplification and different exression of mitotic genes in HCT116 tumor cells 49
A new p65 isoform that bind the glucocorticoid hormone and is expressed in inflammation liver diseases and COVID-19 49
p14ARF re-expression induces apoptosis in aneuploid HCT116 cells 45
Integrated computational and experimental approaches for the identification of new molecules with readthrough activity on premature termination codons (PTCs) in cystic fibrosis cells 43
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells. 42
Specific Irreversible Cell-Cycle Arrest and Depletion of Cancer Cells Obtained by Combining Curcumin and the Flavonoids Quercetin and Fisetin 41
RB, epigenetic changes and chromosomal alterations in human primary fibroblasts in culture 20
Totale 9.319
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Categoria #
all - tutte 35.255
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 35.255
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.072 0 0 0 0 0 217 183 98 169 193 121 91
2020/20211.269 65 115 53 149 158 65 79 79 124 124 126 132
2021/20221.163 53 288 34 29 34 38 39 89 115 155 60 229
2022/20231.611 144 177 38 278 149 246 118 123 174 43 77 44
2023/20241.014 55 118 94 114 78 148 98 144 6 20 10 129
2024/2025656 86 117 89 170 107 87 0 0 0 0 0 0
Totale 9.335