Archivio istituzionale della ricerca dell'Università degli Studi di Palermo

DI LEONARDO, Aldo
 Distribuzione geografica
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Continente #
NA - Nord America 7.340
EU - Europa 5.014
AS - Asia 3.799
SA - Sud America 535
Continente sconosciuto - Info sul continente non disponibili 494
AF - Africa 147
OC - Oceania 21
Totale 17.350
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Nazione #
US - Stati Uniti d'America 7.187
IT - Italia 1.360
SG - Singapore 1.347
RU - Federazione Russa 1.109
CN - Cina 981
DE - Germania 450
BR - Brasile 418
FI - Finlandia 418
UA - Ucraina 387
VN - Vietnam 368
HK - Hong Kong 361
PL - Polonia 239
GB - Regno Unito 230
FR - Francia 210
IE - Irlanda 190
IN - India 169
JP - Giappone 164
SE - Svezia 152
NL - Olanda 79
CA - Canada 76
KR - Corea 75
BD - Bangladesh 74
CI - Costa d'Avorio 55
TR - Turchia 48
BE - Belgio 40
ES - Italia 39
AR - Argentina 34
IQ - Iraq 29
MX - Messico 28
AT - Austria 23
RO - Romania 22
ZA - Sudafrica 22
UZ - Uzbekistan 20
AU - Australia 19
MY - Malesia 19
ID - Indonesia 17
PK - Pakistan 17
CL - Cile 16
CO - Colombia 16
EC - Ecuador 16
MA - Marocco 16
JM - Giamaica 13
VE - Venezuela 13
PT - Portogallo 12
SA - Arabia Saudita 12
KE - Kenya 11
TN - Tunisia 11
GR - Grecia 10
PY - Paraguay 10
AZ - Azerbaigian 9
CH - Svizzera 9
DZ - Algeria 9
EG - Egitto 9
IL - Israele 9
CR - Costa Rica 8
JO - Giordania 8
PH - Filippine 8
SV - El Salvador 8
IR - Iran 7
AE - Emirati Arabi Uniti 6
SY - Repubblica araba siriana 6
CZ - Repubblica Ceca 5
DK - Danimarca 5
ET - Etiopia 5
KZ - Kazakistan 5
LB - Libano 5
LT - Lituania 5
PE - Perù 5
QA - Qatar 5
TW - Taiwan 5
BO - Bolivia 4
DO - Repubblica Dominicana 4
KW - Kuwait 4
NP - Nepal 4
SK - Slovacchia (Repubblica Slovacca) 4
BG - Bulgaria 3
GE - Georgia 3
HN - Honduras 3
NG - Nigeria 3
RS - Serbia 3
UY - Uruguay 3
XK - ???statistics.table.value.countryCode.XK??? 3
AL - Albania 2
BY - Bielorussia 2
BZ - Belize 2
CY - Cipro 2
GT - Guatemala 2
KG - Kirghizistan 2
KH - Cambogia 2
LA - Repubblica Popolare Democratica del Laos 2
MD - Moldavia 2
NI - Nicaragua 2
NO - Norvegia 2
NZ - Nuova Zelanda 2
PA - Panama 2
PR - Porto Rico 2
PS - Palestinian Territory 2
TH - Thailandia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AO - Angola 1
Totale 16.848
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Città #
Singapore 984
Ashburn 872
Fairfield 598
San Jose 547
Palermo 449
Chandler 395
Hong Kong 345
Ann Arbor 318
Woodbridge 315
Houston 300
Wilmington 281
Seattle 210
Jacksonville 205
Zgierz 204
Cambridge 190
Dublin 188
Moscow 187
Council Bluffs 180
Beijing 158
Medford 149
Tokyo 134
Santa Clara 118
Los Angeles 116
Des Moines 115
Ho Chi Minh City 111
Nanjing 97
New York 95
Hanoi 94
Princeton 94
Dallas 92
Helsinki 91
Hyderabad 89
Lauterbourg 86
Bremen 82
Frankfurt am Main 82
Boardman 72
Hefei 63
Milan 61
Tulsa 57
Abidjan 55
Altamura 53
The Dalles 52
Buffalo 51
San Diego 45
Rome 43
Dearborn 41
Shenyang 38
Changsha 37
Jinan 37
Lawrence 37
São Paulo 37
Chicago 35
Ludwigshafen am Rhein 34
London 30
Brussels 29
Nanchang 29
Paris 29
Hebei 28
Tianjin 28
Düsseldorf 27
Phoenix 27
Orem 26
Venice 26
Jiaxing 25
Philadelphia 24
Ningbo 23
Amsterdam 22
Verona 22
Izmir 21
Redwood City 21
Guangzhou 20
Naples 20
Da Nang 19
Toronto 19
Brooklyn 16
Chikmagalūr 16
Haiphong 16
Montreal 16
Seongnam 16
Warsaw 16
Saint Petersburg 15
Tashkent 15
Columbus 14
Atlanta 13
Bacoli 13
Birmingham 13
Haikou 13
Nuremberg 13
Johannesburg 12
Kumar 12
Poplar 12
Volturara Irpina 12
Washington 12
Baghdad 11
Kingston 11
Kuala Lumpur 11
San Francisco 11
Stockholm 11
Sydney 11
Taizhou 11
Totale 10.276
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Nome #
Inhibition of FTSJ1, a tryptophan tRNA-specific 2’-O-methyltransferase as possible mechanism to readthrough premature termination codons (UGAs) of the CFTR mRNA 296
Caffeine boosts Ataluren's readthrough activity 287
P015 Translational readthrough inducing drugs: a study of toxicity in mice models and in vitro safety validation of the specific readthrough process. 287
Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives 285
Investigating CRISPR-CAS13b as a tool for the RNA editing of CFTR mRNA with premature stop codon 279
Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells 264
CENPA overexpression promotes genome instability in pRb-depleted human cells. 257
Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay 254
Retinoblastoma epidemiology: Does the evidence matter? 245
Aurora-A transcriptional silencing and Vincristine treatment show a synergistic effect in human tumor cells 239
AZIONE READTHROUGH DI DERIVATI DEL PTC124 SU SISTEMI MODELLO CELLULARI E IN CELLULE DI EPITELIO BRONCHIALE-FC IB3.1 (CFTR F508/W1282X ) 239
Derivati Ossadiazolici per il trattamento della fibrosi cistica: Readthrough di mutazioni nonsense 234
p14(ARF) Prevents Proliferation of Aneuploid Cells by Inducing p53-Dependent Apoptosis 229
Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype 228
DNA demethylation caused By 5-Aza-2'-Deoxycytidine induces mitotic alterations and aneuploidy 218
DNMT1 depletion activates a pathway p14ARF/TP53 controlled that induces G1 arrest preventing DNA demethylation and aneuploidy 215
Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts 214
Expression of the kinetochore protein Hec1 during the cell cycle in normal and cancer cells and its regulation by the pRb pathway. 214
Nonsense codons suppression. An acute toxicity study of three optimized TRIDs in murine model, safety and tolerability evaluation 210
Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) 208
P14ARF: The absence that makes the difference 204
Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening 202
Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs 201
Aneuploid IMR90 cells induced by depletion of pRB, DNMT1 and MAD2 show a common gene expression signature 198
Identification of pathways involved in aneuploidy onset and its tolerance using a DNA microarray approach 197
Premature termination codon 124 derivatives as a novel approach to improve the read-through of premature amber and ochre stop codons 197
Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution evaluation in mice models 191
RNAi mediated acute depletion of Retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation 190
NOTCH3 expression is linked to breast cancer seeding and distant metastasis 189
Proliferation of aneuploid cells induced by CENP-E depletion is counteracted by the p14ARFtumor suppressor 187
Simultaneous reduction of MAD2 and BUBR1 expression induces mitotic spindle alterations associated with p53 dependent cell cycle arrest and death 186
Targeting nonsense: Optimization of 1,2,4-oxadiazole trids to rescue cftr expression and functionality in cystic fibrosis cell model systems 186
Aurora-A/STK15 transcriptional silencing and Vincristine treatment show a synergistic effect in human tumour cells 184
MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a P53 pathway preventing aneuploid cells propagation. 184
EFFECTS OF PLK1 DEPLETION IN CENTROSOME DUPLICATIONS AND CELL CYCLEPROGRESSION IN HCT116 TUMOR CELLS. 183
Acute loss of retinoblastoma function induces centrosomes amplification both in murine and human fibroblasts 182
Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons 182
Acute loss of pRB function induces centrosome amplification and aneuploidy both in murine and human fibroblasts 181
RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts 181
Low doses of Hydroxyurea induce centrosome amplification and aneuploidy in primary human fibroblasts in culture 178
Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells 175
Aurora A overexpression leads centrosome amplification and aneuploidy in human colon cancer cells with MIN phenotype 174
Acute loss of pRb induces centrosome amplification and aneuploidy both in human and murine primary fibroblasts 173
Bypass of G1 arrest induced by DNMT1 posttranscriptional silencing triggers aneuploidy in human cells. 172
The sea urchin sns insulator blocks CMV enhancer following integration in human cells 170
Acute loss of retinoblastoma function induces centrosome amplification and aneuploidy both in human and murine primary fibroblasts 168
Functional inactivation of pRB results in aneuploid mammalian cells after release from a mitotic block 168
Aneuploidia e alterazione dei centrosomi in MEF pRb deficienti. 167
RNA Editing Approaches for the correction of nonsense mutation in a cell model for Cystic Fibrosis 164
Acute loss of pRB function induces centrosome amplification and aneuploidy in human fibroblasts 164
Micronuclei generation and chromosomal instability after RB interferences in human fibroblasts 164
DNA Methyltransferase1 post-transcriptional silencing induces aneuploidy and cell cycle arrest in human cells. 162
PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene. 162
AURKA (aurora kinase A) 159
Transcriptomic changes following partial depletion of cenp‐e in normal human fibroblasts 156
Does the evidence matter in medicine? The retinoblastoma paradigm. 154
Chromosomal instability promoted by RB depletion relied neither on p53 nor SAC dysfunction in HCT116 tumor cells 154
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells 154
Global DNA Hypomethylation following 5-aza-2'-deoxycytidine treatment induces aneuploidy in HCT-116 tumor cells. 153
Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs 153
The tumor suppressor p14ARF hampers proliferation of aneuploid cells induced by CENP-E partial depletion 152
A new p65 isoform that bind the glucocorticoid hormone and is expressed in inflammation liver diseases and COVID-19 152
Aneuploidy induced by MAD2 haploinsufficiency triggers premature senescence in human primary fibroblast 151
The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. 151
Identification of pathways involved in aneuploidy onset and its tolerance using a DNA microarray approach 151
Effetti del Silenziamento dei geni Plk1, Brca1 e Rb nella duplicazione dei centrosomi in cellule tumorali HCT116 148
Silencing of serine threonine kinase Aurora-2 gene cause G2/M arrest and apotosis in human carcinoma lung large cells 148
Hydroxiurea induces centrosome amplification and slowing down of cell cycle in colo-cancer cells SW480 147
CFTR G542X/ G542X mouse model carrying nonsense mutations, useful tool to test the efficacy of translational readthrough-based therapy in Cystic Fibrosis 145
Hydroxyurea induces centrosome amplification and slowing down of cell cycle in colo-cancer cells SW480 145
Silencing of serine threonine kinase Aurora-2 gene causes G2/M arrest and apoptosis in human carcinoma lung large cells. 143
Missing evidences in cancer genetics: The retinoblastoma paradigm. 143
Inhalable nano into micro dry powders for ivacaftor delivery: the role of mannitol and cysteamine as mucus-active agents 143
Chromosome Instability, friend or foe: genetic and epigenetic causes in cancer 139
PTC124 DERIVATIVES AS A NOVEL APPROACH TO IMPROVE THE READTHROUGH OF PREMATURE AMBER AND OCHRE STOP CODONS 134
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the readthrough of PTCs in CF cells 133
Identification of a new molecule with readthrough activity to rescue CFTR protein function 133
Transient silencing of MAD2 induces mitotic abnormalities and p21waf1 overexpression in primary human fibroblasts 132
X CONVENTION OF INVESTIGATORS IN CYSTIC FIBROSIS 130
RB acute loss affects expression of mitotic genes and is associated with centrosome amplification and aneuploidy 128
Effects of Plk1 depletion on centrosome duplication and cell cycle progression in HCT116 tumor cells 127
DNMT1 transient silencing induces aneuploidy, premature separated chromatids and centromeric chromatin alterations 127
Identification of mechanism(s) leading to hyperdiploidy in progenitor tumor cells derived from MCF7 breast cancer cells 126
Transient and stable depletion of RB induce different expression of genes involved in epigenetic modifications. 123
p14ARF re-expression induces apoptosis in aneuploid HCT116 cells 122
Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells 118
Specific Irreversible Cell-Cycle Arrest and Depletion of Cancer Cells Obtained by Combining Curcumin and the Flavonoids Quercetin and Fisetin 114
pRb loss and chromosomal instability in human cells. 114
Effetti del silenziamento dei geni Plk1, Brca1 ed Rb nella duplicazione dei centrosomi in cellule tumorali HCT116 111
RNA interference of MAD2 and BUBR1 genes causes mitotic spindle alterations, aneuploidy and cell cycle arrest p53-dependent. 111
“DNA Methyl transferase 1 post-trascriptional silencing indues aneuploidy and cell cycle arrest in human cells”, 110
Gene amplification in fibroblasts from ataxia telangiectasia (AT) patients and in X-ray hypersensitive AT-like Chinese hamster mutants 110
STK15 overexpression in HCT116 cells causes mitotic disorders and hypodiploidy associated with centrosome amplification. 106
PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene 105
Rb depletion induces centrosome amplification and different exression of mitotic genes in HCT116 tumor cells 104
The retinoblastoma paradigm revisited 100
Integrated computational and experimental approaches for the identification of new molecules with readthrough activity on premature termination codons (PTCs) in cystic fibrosis cells 99
Pyrazole[3,4-d]pyrimidine derivatives loaded into halloysite as potential CDK inhibitors 98
RNA editing applied to cystic fibrosis: RESTORE can target G542X CFTR mRNA and revert the nonsense mutation 97
OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS 92
Totale 17.013
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Categoria #
all - tutte 57.918
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 57.918
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022822 0 0 34 29 34 38 39 89 115 155 60 229
2022/20231.611 144 177 38 278 149 246 118 123 174 43 77 44
2023/20241.014 55 118 94 114 78 148 98 144 6 20 10 129
2024/20251.887 86 117 89 170 107 93 134 96 124 212 235 424
2025/20266.269 400 142 320 472 644 904 944 703 486 793 229 232
2026/2027515 312 199 4 0 0 0 0 0 0 0 0 0
Totale 17.350