Archivio istituzionale della ricerca dell'Università degli Studi di Palermo

DI LEONARDO, Aldo
 Distribuzione geografica
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Continente #
NA - Nord America 4.715
EU - Europa 2.829
AS - Asia 926
AF - Africa 59
SA - Sud America 22
OC - Oceania 11
Continente sconosciuto - Info sul continente non disponibili 4
Totale 8.566
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Nazione #
US - Stati Uniti d'America 4.696
IT - Italia 1.061
CN - Cina 493
UA - Ucraina 373
FI - Finlandia 335
DE - Germania 290
IE - Irlanda 182
SG - Singapore 182
GB - Regno Unito 156
SE - Svezia 139
IN - India 124
FR - Francia 69
RU - Federazione Russa 63
CI - Costa d'Avorio 54
BE - Belgio 40
JP - Giappone 36
NL - Olanda 36
TR - Turchia 26
RO - Romania 22
KR - Corea 21
ES - Italia 15
HK - Hong Kong 15
CA - Canada 13
PL - Polonia 11
AU - Australia 9
GR - Grecia 9
BR - Brasile 8
CL - Cile 8
CH - Svizzera 7
AT - Austria 6
MX - Messico 6
DK - Danimarca 5
IL - Israele 5
PK - Pakistan 5
CO - Colombia 4
UZ - Uzbekistan 4
DZ - Algeria 3
IR - Iran 3
MY - Malesia 3
SK - Slovacchia (Repubblica Slovacca) 3
NO - Norvegia 2
NZ - Nuova Zelanda 2
PT - Portogallo 2
TW - Taiwan 2
UY - Uruguay 2
VN - Vietnam 2
XK - ???statistics.table.value.countryCode.XK??? 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AE - Emirati Arabi Uniti 1
BG - Bulgaria 1
CZ - Repubblica Ceca 1
EU - Europa 1
ID - Indonesia 1
LB - Libano 1
MD - Moldavia 1
PS - Palestinian Territory 1
TH - Thailandia 1
TN - Tunisia 1
ZA - Sudafrica 1
Totale 8.566
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Città #
Fairfield 598
Ashburn 418
Chandler 395
Palermo 348
Ann Arbor 318
Woodbridge 315
Houston 286
Wilmington 281
Jacksonville 203
Seattle 203
Cambridge 189
Dublin 181
Medford 149
Singapore 129
Des Moines 106
Nanjing 96
Princeton 94
Hyderabad 87
Bremen 82
Boardman 64
Tulsa 56
Abidjan 54
Altamura 53
Milan 50
Beijing 48
San Diego 45
Dearborn 41
Shenyang 38
Lawrence 37
Jinan 36
Changsha 35
Ludwigshafen am Rhein 34
New York 31
Brussels 29
Nanchang 29
Hebei 28
Santa Clara 28
Düsseldorf 27
Tianjin 27
Jiaxing 25
Rome 25
Venice 24
London 22
Ningbo 22
Redwood City 21
Izmir 20
Paris 19
Los Angeles 17
Philadelphia 17
Chikmagalūr 16
Helsinki 16
Seongnam 16
Verona 16
Saint Petersburg 15
Bacoli 13
Amsterdam 12
Haikou 12
Kumar 12
Phoenix 12
Volturara Irpina 12
Guangzhou 11
Taizhou 11
Tokyo 11
Barcelona 10
Edinburgh 10
San Paolo di Civitate 10
Washington 9
Zhengzhou 9
Apeldoorn 8
Kunming 8
Baltimore 7
Lanzhou 7
Naples 7
San Mateo 7
Trapani 7
Alcamo 6
Carovigno 6
Frankfurt am Main 6
Hong Kong 6
Kilburn 6
Orange 6
Redmond 6
Turin 6
Carini 5
Catania 5
Dallas 5
Flower Mound 5
Frankfurt 5
Fuzhou 5
Norwalk 5
Rawalpindi 5
Taiyuan 5
Tappahannock 5
Berlin 4
Birmingham 4
Cali 4
Chicago 4
Florence 4
Hangzhou 4
Jersey City 4
Totale 5.890
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Nome #
Caffeine boosts Ataluren's readthrough activity 185
Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives 184
Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells 181
Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay 181
Retinoblastoma epidemiology: Does the evidence matter? 173
CENPA overexpression promotes genome instability in pRb-depleted human cells. 170
Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype 161
Inhibition of FTSJ1, a tryptophan tRNA-specific 2’-O-methyltransferase as possible mechanism to readthrough premature termination codons (UGAs) of the CFTR mRNA 159
P015 Translational readthrough inducing drugs: a study of toxicity in mice models and in vitro safety validation of the specific readthrough process. 159
p14(ARF) Prevents Proliferation of Aneuploid Cells by Inducing p53-Dependent Apoptosis 158
Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening 151
Investigating CRISPR-CAS13b as a tool for the RNA editing of CFTR mRNA with premature stop codon 148
NOTCH3 expression is linked to breast cancer seeding and distant metastasis 147
Expression of the kinetochore protein Hec1 during the cell cycle in normal and cancer cells and its regulation by the pRb pathway. 142
Aurora-A transcriptional silencing and Vincristine treatment show a synergistic effect in human tumor cells 137
Derivati Ossadiazolici per il trattamento della fibrosi cistica: Readthrough di mutazioni nonsense 135
Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs 135
AZIONE READTHROUGH DI DERIVATI DEL PTC124 SU SISTEMI MODELLO CELLULARI E IN CELLULE DI EPITELIO BRONCHIALE-FC IB3.1 (CFTR F508/W1282X ) 128
Functional inactivation of pRB results in aneuploid mammalian cells after release from a mitotic block 128
MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a P53 pathway preventing aneuploid cells propagation. 127
RNAi mediated acute depletion of Retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation 123
DNA demethylation caused By 5-Aza-2'-Deoxycytidine induces mitotic alterations and aneuploidy 122
Targeting nonsense: Optimization of 1,2,4-oxadiazole trids to rescue cftr expression and functionality in cystic fibrosis cell model systems 122
Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts 120
P14ARF: The absence that makes the difference 119
Proliferation of aneuploid cells induced by CENP-E depletion is counteracted by the p14ARFtumor suppressor 119
Does the evidence matter in medicine? The retinoblastoma paradigm. 117
Simultaneous reduction of MAD2 and BUBR1 expression induces mitotic spindle alterations associated with p53 dependent cell cycle arrest and death 117
Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) 112
RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts 111
The sea urchin sns insulator blocks CMV enhancer following integration in human cells 111
Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons 110
Premature termination codon 124 derivatives as a novel approach to improve the read-through of premature amber and ochre stop codons 108
Aneuploid IMR90 cells induced by depletion of pRB, DNMT1 and MAD2 show a common gene expression signature 106
DNMT1 depletion activates a pathway p14ARF/TP53 controlled that induces G1 arrest preventing DNA demethylation and aneuploidy 105
Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells 102
PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene. 101
The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. 94
Low doses of Hydroxyurea induce centrosome amplification and aneuploidy in primary human fibroblasts in culture 91
Micronuclei generation and chromosomal instability after RB interferences in human fibroblasts 90
Acute loss of pRB function induces centrosome amplification and aneuploidy both in murine and human fibroblasts 89
Chromosomal instability promoted by RB depletion relied neither on p53 nor SAC dysfunction in HCT116 tumor cells 86
Aurora-A/STK15 transcriptional silencing and Vincristine treatment show a synergistic effect in human tumour cells 85
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells 84
Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs 81
Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution evaluation in mice models 79
Acute loss of pRB function induces centrosome amplification and aneuploidy in human fibroblasts 78
Acute loss of retinoblastoma function induces centrosomes amplification both in murine and human fibroblasts 78
Identification of a new molecule with readthrough activity to rescue CFTR protein function 77
AURKA (aurora kinase A) 76
PTC124 DERIVATIVES AS A NOVEL APPROACH TO IMPROVE THE READTHROUGH OF PREMATURE AMBER AND OCHRE STOP CODONS 76
Aneuploidia e alterazione dei centrosomi in MEF pRb deficienti. 75
Acute loss of retinoblastoma function induces centrosome amplification and aneuploidy both in human and murine primary fibroblasts 74
Aneuploidy induced by MAD2 haploinsufficiency triggers premature senescence in human primary fibroblast 74
Gene amplification in fibroblasts from ataxia telangiectasia (AT) patients and in X-ray hypersensitive AT-like Chinese hamster mutants 74
Inhalable nano into micro dry powders for ivacaftor delivery: the role of mannitol and cysteamine as mucus-active agents 73
Aurora A overexpression leads centrosome amplification and aneuploidy in human colon cancer cells with MIN phenotype 71
EFFECTS OF PLK1 DEPLETION IN CENTROSOME DUPLICATIONS AND CELL CYCLEPROGRESSION IN HCT116 TUMOR CELLS. 70
DNA Methyltransferase1 post-transcriptional silencing induces aneuploidy and cell cycle arrest in human cells. 70
Bypass of G1 arrest induced by DNMT1 posttranscriptional silencing triggers aneuploidy in human cells. 70
Acute loss of pRb induces centrosome amplification and aneuploidy both in human and murine primary fibroblasts 69
X CONVENTION OF INVESTIGATORS IN CYSTIC FIBROSIS. 69
DNMT1 transient silencing induces aneuploidy, premature separated chromatids and centromeric chromatin alterations 68
Nonsense codons suppression. An acute toxicity study of three optimized TRIDs in murine model, safety and tolerability evaluation 67
Hydroxyurea induces centrosome amplification and slowing down of cell cycle in colo-cancer cells SW480 65
Identification of pathways involved in aneuploidy onset and its tolerance using a DNA microarray approach 65
Global DNA Hypomethylation following 5-aza-2'-deoxycytidine treatment induces aneuploidy in HCT-116 tumor cells. 65
Missing evidences in cancer genetics: The retinoblastoma paradigm. 64
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the readthrough of PTCs in CF cells 63
Effetti del Silenziamento dei geni Plk1, Brca1 e Rb nella duplicazione dei centrosomi in cellule tumorali HCT116 62
Silencing of serine threonine kinase Aurora-2 gene causes G2/M arrest and apoptosis in human carcinoma lung large cells. 62
Silencing of serine threonine kinase Aurora-2 gene cause G2/M arrest and apotosis in human carcinoma lung large cells 61
“DNA Methyl transferase 1 post-trascriptional silencing indues aneuploidy and cell cycle arrest in human cells”, 61
Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells 60
Transient and stable depletion of RB induce different expression of genes involved in epigenetic modifications. 59
Effects of Plk1 depletion on centrosome duplication and cell cycle progression in HCT116 tumor cells 58
Transient silencing of MAD2 induces mitotic abnormalities and p21waf1 overexpression in primary human fibroblasts 58
STK15 overexpression in HCT116 cells causes mitotic disorders and hypodiploidy associated with centrosome amplification. 57
Hydroxiurea induces centrosome amplification and slowing down of cell cycle in colo-cancer cells SW480 57
RNA Editing Approaches for the correction of nonsense mutation in a cell model for Cystic Fibrosis 56
Effetti del silenziamento dei geni Plk1, Brca1 ed Rb nella duplicazione dei centrosomi in cellule tumorali HCT116 56
Transcriptomic changes following partial depletion of cenp‐e in normal human fibroblasts 56
RNA interference of MAD2 and BUBR1 genes causes mitotic spindle alterations, aneuploidy and cell cycle arrest p53-dependent. 55
The retinoblastoma paradigm revisited 55
pRb loss and chromosomal instability in human cells. 55
Identification of mechanism(s) leading to hyperdiploidy in progenitor tumor cells derived from MCF7 breast cancer cells 53
RB acute loss affects expression of mitotic genes and is associated with centrosome amplification and aneuploidy 52
PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene 52
Identification of pathways involved in aneuploidy onset and its tolerance using a DNA microarray approach 51
The tumor suppressor p14ARF hampers proliferation of aneuploid cells induced by CENP-E partial depletion 51
Pyrazole[3,4-d]pyrimidine derivatives loaded into halloysite as potential CDK inhibitors 50
OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS 49
Rb depletion induces centrosome amplification and different exression of mitotic genes in HCT116 tumor cells 48
A new p65 isoform that bind the glucocorticoid hormone and is expressed in inflammation liver diseases and COVID-19 46
Chromosome Instability, friend or foe: genetic and epigenetic causes in cancer 45
p14ARF re-expression induces apoptosis in aneuploid HCT116 cells 42
Integrated computational and experimental approaches for the identification of new molecules with readthrough activity on premature termination codons (PTCs) in cystic fibrosis cells 41
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells. 41
Specific Irreversible Cell-Cycle Arrest and Depletion of Cancer Cells Obtained by Combining Curcumin and the Flavonoids Quercetin and Fisetin 31
RB, epigenetic changes and chromosomal alterations in human primary fibroblasts in culture 13
Totale 9.017
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Categoria #
all - tutte 33.306
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 33.306
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.391 0 0 0 122 197 217 183 98 169 193 121 91
2020/20211.269 65 115 53 149 158 65 79 79 124 124 126 132
2021/20221.163 53 288 34 29 34 38 39 89 115 155 60 229
2022/20231.611 144 177 38 278 149 246 118 123 174 43 77 44
2023/20241.014 55 118 94 114 78 148 98 144 6 20 10 129
2024/2025349 86 117 89 57 0 0 0 0 0 0 0 0
Totale 9.028