Archivio istituzionale della ricerca dell'Università degli Studi di Palermo

DI LEONARDO, Aldo
 Distribuzione geografica
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Continente #
NA - Nord America 6.708
EU - Europa 4.956
AS - Asia 3.742
SA - Sud America 510
AF - Africa 146
OC - Oceania 14
Continente sconosciuto - Info sul continente non disponibili 5
Totale 16.081
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Nazione #
US - Stati Uniti d'America 6.609
SG - Singapore 1.344
IT - Italia 1.319
RU - Federazione Russa 1.109
CN - Cina 978
DE - Germania 450
FI - Finlandia 418
BR - Brasile 413
UA - Ucraina 387
VN - Vietnam 364
HK - Hong Kong 356
PL - Polonia 239
GB - Regno Unito 230
FR - Francia 205
IE - Irlanda 190
IN - India 168
JP - Giappone 162
SE - Svezia 148
NL - Olanda 77
KR - Corea 75
CI - Costa d'Avorio 55
CA - Canada 52
TR - Turchia 47
BD - Bangladesh 44
BE - Belgio 40
ES - Italia 36
AR - Argentina 32
IQ - Iraq 29
AT - Austria 23
MX - Messico 22
RO - Romania 22
ZA - Sudafrica 22
UZ - Uzbekistan 20
MY - Malesia 17
PK - Pakistan 17
CL - Cile 16
ID - Indonesia 16
MA - Marocco 16
AU - Australia 12
SA - Arabia Saudita 12
EC - Ecuador 11
KE - Kenya 11
PT - Portogallo 11
TN - Tunisia 11
GR - Grecia 10
VE - Venezuela 10
AZ - Azerbaigian 9
CH - Svizzera 9
CO - Colombia 9
DZ - Algeria 9
EG - Egitto 9
IL - Israele 9
JM - Giamaica 9
PY - Paraguay 8
IR - Iran 7
JO - Giordania 7
PH - Filippine 7
AE - Emirati Arabi Uniti 6
SY - Repubblica araba siriana 6
DK - Danimarca 5
ET - Etiopia 5
KZ - Kazakistan 5
LB - Libano 5
LT - Lituania 5
TW - Taiwan 5
BO - Bolivia 4
CR - Costa Rica 4
CZ - Repubblica Ceca 4
KW - Kuwait 4
NP - Nepal 4
PE - Perù 4
SK - Slovacchia (Repubblica Slovacca) 4
BG - Bulgaria 3
GE - Georgia 3
NG - Nigeria 3
QA - Qatar 3
RS - Serbia 3
UY - Uruguay 3
XK - ???statistics.table.value.countryCode.XK??? 3
AL - Albania 2
BY - Bielorussia 2
CY - Cipro 2
DO - Repubblica Dominicana 2
KG - Kirghizistan 2
KH - Cambogia 2
NI - Nicaragua 2
NO - Norvegia 2
NZ - Nuova Zelanda 2
PS - Palestinian Territory 2
TH - Thailandia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AO - Angola 1
BB - Barbados 1
BH - Bahrain 1
BN - Brunei Darussalam 1
BS - Bahamas 1
BZ - Belize 1
CG - Congo 1
EU - Europa 1
GT - Guatemala 1
Totale 16.070
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Città #
Singapore 981
Ashburn 841
Fairfield 598
Palermo 444
San Jose 402
Chandler 395
Hong Kong 342
Ann Arbor 318
Woodbridge 315
Houston 298
Wilmington 281
Seattle 209
Jacksonville 204
Zgierz 204
Cambridge 189
Dublin 188
Moscow 187
Beijing 156
Medford 149
Tokyo 132
Des Moines 115
Ho Chi Minh City 110
Council Bluffs 107
Los Angeles 106
Santa Clara 100
Nanjing 97
Princeton 94
Hanoi 93
New York 92
Helsinki 91
Dallas 90
Hyderabad 89
Lauterbourg 86
Bremen 82
Frankfurt am Main 82
Boardman 64
Hefei 63
Milan 57
Tulsa 57
Abidjan 55
Altamura 53
The Dalles 51
Buffalo 48
San Diego 45
Dearborn 41
Rome 41
Shenyang 38
Changsha 37
Jinan 37
Lawrence 37
São Paulo 37
Ludwigshafen am Rhein 34
London 30
Brussels 29
Chicago 29
Nanchang 29
Paris 29
Hebei 28
Tianjin 28
Düsseldorf 27
Orem 26
Venice 26
Jiaxing 25
Ningbo 23
Amsterdam 22
Verona 22
Izmir 21
Philadelphia 21
Redwood City 21
Guangzhou 20
Phoenix 20
Da Nang 19
Naples 18
Chikmagalūr 16
Haiphong 16
Seongnam 16
Warsaw 16
Montreal 15
Saint Petersburg 15
Tashkent 15
Columbus 14
Bacoli 13
Brooklyn 13
Haikou 13
Nuremberg 13
Atlanta 12
Birmingham 12
Johannesburg 12
Kumar 12
Poplar 12
Volturara Irpina 12
Baghdad 11
San Francisco 11
Taizhou 11
Toronto 11
Washington 11
Zhengzhou 11
Barcelona 10
Belo Horizonte 10
Cardiff 10
Totale 9.918
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Nome #
Inhibition of FTSJ1, a tryptophan tRNA-specific 2’-O-methyltransferase as possible mechanism to readthrough premature termination codons (UGAs) of the CFTR mRNA 287
P015 Translational readthrough inducing drugs: a study of toxicity in mice models and in vitro safety validation of the specific readthrough process. 279
Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives 277
Caffeine boosts Ataluren's readthrough activity 277
Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells 261
Investigating CRISPR-CAS13b as a tool for the RNA editing of CFTR mRNA with premature stop codon 261
CENPA overexpression promotes genome instability in pRb-depleted human cells. 250
Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay 246
Retinoblastoma epidemiology: Does the evidence matter? 240
Aurora-A transcriptional silencing and Vincristine treatment show a synergistic effect in human tumor cells 233
AZIONE READTHROUGH DI DERIVATI DEL PTC124 SU SISTEMI MODELLO CELLULARI E IN CELLULE DI EPITELIO BRONCHIALE-FC IB3.1 (CFTR F508/W1282X ) 231
Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype 224
p14(ARF) Prevents Proliferation of Aneuploid Cells by Inducing p53-Dependent Apoptosis 221
Derivati Ossadiazolici per il trattamento della fibrosi cistica: Readthrough di mutazioni nonsense 218
DNA demethylation caused By 5-Aza-2'-Deoxycytidine induces mitotic alterations and aneuploidy 212
Expression of the kinetochore protein Hec1 during the cell cycle in normal and cancer cells and its regulation by the pRb pathway. 210
DNMT1 depletion activates a pathway p14ARF/TP53 controlled that induces G1 arrest preventing DNA demethylation and aneuploidy 210
Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts 208
P14ARF: The absence that makes the difference 200
Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) 198
Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening 197
Identification of pathways involved in aneuploidy onset and its tolerance using a DNA microarray approach 193
Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs 193
Aneuploid IMR90 cells induced by depletion of pRB, DNMT1 and MAD2 show a common gene expression signature 191
RNAi mediated acute depletion of Retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation 186
Premature termination codon 124 derivatives as a novel approach to improve the read-through of premature amber and ochre stop codons 186
Proliferation of aneuploid cells induced by CENP-E depletion is counteracted by the p14ARFtumor suppressor 185
Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution evaluation in mice models 184
NOTCH3 expression is linked to breast cancer seeding and distant metastasis 183
MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a P53 pathway preventing aneuploid cells propagation. 179
Acute loss of pRB function induces centrosome amplification and aneuploidy both in murine and human fibroblasts 177
Simultaneous reduction of MAD2 and BUBR1 expression induces mitotic spindle alterations associated with p53 dependent cell cycle arrest and death 177
Targeting nonsense: Optimization of 1,2,4-oxadiazole trids to rescue cftr expression and functionality in cystic fibrosis cell model systems 177
Acute loss of retinoblastoma function induces centrosomes amplification both in murine and human fibroblasts 176
Aurora-A/STK15 transcriptional silencing and Vincristine treatment show a synergistic effect in human tumour cells 176
EFFECTS OF PLK1 DEPLETION IN CENTROSOME DUPLICATIONS AND CELL CYCLEPROGRESSION IN HCT116 TUMOR CELLS. 175
Nonsense codons suppression. An acute toxicity study of three optimized TRIDs in murine model, safety and tolerability evaluation 174
RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts 174
Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons 172
Low doses of Hydroxyurea induce centrosome amplification and aneuploidy in primary human fibroblasts in culture 170
Aurora A overexpression leads centrosome amplification and aneuploidy in human colon cancer cells with MIN phenotype 169
Bypass of G1 arrest induced by DNMT1 posttranscriptional silencing triggers aneuploidy in human cells. 168
Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells 167
Acute loss of pRb induces centrosome amplification and aneuploidy both in human and murine primary fibroblasts 166
Acute loss of retinoblastoma function induces centrosome amplification and aneuploidy both in human and murine primary fibroblasts 164
Functional inactivation of pRB results in aneuploid mammalian cells after release from a mitotic block 164
Aneuploidia e alterazione dei centrosomi in MEF pRb deficienti. 162
Acute loss of pRB function induces centrosome amplification and aneuploidy in human fibroblasts 160
The sea urchin sns insulator blocks CMV enhancer following integration in human cells 160
Micronuclei generation and chromosomal instability after RB interferences in human fibroblasts 157
DNA Methyltransferase1 post-transcriptional silencing induces aneuploidy and cell cycle arrest in human cells. 157
PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene. 153
RNA Editing Approaches for the correction of nonsense mutation in a cell model for Cystic Fibrosis 152
Does the evidence matter in medicine? The retinoblastoma paradigm. 152
Transcriptomic changes following partial depletion of cenp‐e in normal human fibroblasts 151
Global DNA Hypomethylation following 5-aza-2'-deoxycytidine treatment induces aneuploidy in HCT-116 tumor cells. 150
Chromosomal instability promoted by RB depletion relied neither on p53 nor SAC dysfunction in HCT116 tumor cells 148
AURKA (aurora kinase A) 145
The tumor suppressor p14ARF hampers proliferation of aneuploid cells induced by CENP-E partial depletion 145
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells 144
A new p65 isoform that bind the glucocorticoid hormone and is expressed in inflammation liver diseases and COVID-19 144
Silencing of serine threonine kinase Aurora-2 gene cause G2/M arrest and apotosis in human carcinoma lung large cells 143
Aneuploidy induced by MAD2 haploinsufficiency triggers premature senescence in human primary fibroblast 143
Identification of pathways involved in aneuploidy onset and its tolerance using a DNA microarray approach 141
Hydroxyurea induces centrosome amplification and slowing down of cell cycle in colo-cancer cells SW480 140
Effetti del Silenziamento dei geni Plk1, Brca1 e Rb nella duplicazione dei centrosomi in cellule tumorali HCT116 140
The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells. 139
Silencing of serine threonine kinase Aurora-2 gene causes G2/M arrest and apoptosis in human carcinoma lung large cells. 138
Hydroxiurea induces centrosome amplification and slowing down of cell cycle in colo-cancer cells SW480 138
Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs 138
CFTR G542X/ G542X mouse model carrying nonsense mutations, useful tool to test the efficacy of translational readthrough-based therapy in Cystic Fibrosis 135
Inhalable nano into micro dry powders for ivacaftor delivery: the role of mannitol and cysteamine as mucus-active agents 133
Chromosome Instability, friend or foe: genetic and epigenetic causes in cancer 131
PTC124 DERIVATIVES AS A NOVEL APPROACH TO IMPROVE THE READTHROUGH OF PREMATURE AMBER AND OCHRE STOP CODONS 129
Identification of a new molecule with readthrough activity to rescue CFTR protein function 127
Transient silencing of MAD2 induces mitotic abnormalities and p21waf1 overexpression in primary human fibroblasts 125
RB acute loss affects expression of mitotic genes and is associated with centrosome amplification and aneuploidy 124
X CONVENTION OF INVESTIGATORS IN CYSTIC FIBROSIS 124
DNMT1 transient silencing induces aneuploidy, premature separated chromatids and centromeric chromatin alterations 122
Identification of mechanism(s) leading to hyperdiploidy in progenitor tumor cells derived from MCF7 breast cancer cells 122
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the readthrough of PTCs in CF cells 122
Effects of Plk1 depletion on centrosome duplication and cell cycle progression in HCT116 tumor cells 120
Transient and stable depletion of RB induce different expression of genes involved in epigenetic modifications. 115
p14ARF re-expression induces apoptosis in aneuploid HCT116 cells 115
Specific Irreversible Cell-Cycle Arrest and Depletion of Cancer Cells Obtained by Combining Curcumin and the Flavonoids Quercetin and Fisetin 110
Missing evidences in cancer genetics: The retinoblastoma paradigm. 109
Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells 109
Gene amplification in fibroblasts from ataxia telangiectasia (AT) patients and in X-ray hypersensitive AT-like Chinese hamster mutants 108
“DNA Methyl transferase 1 post-trascriptional silencing indues aneuploidy and cell cycle arrest in human cells”, 107
pRb loss and chromosomal instability in human cells. 107
Effetti del silenziamento dei geni Plk1, Brca1 ed Rb nella duplicazione dei centrosomi in cellule tumorali HCT116 106
RNA interference of MAD2 and BUBR1 genes causes mitotic spindle alterations, aneuploidy and cell cycle arrest p53-dependent. 106
STK15 overexpression in HCT116 cells causes mitotic disorders and hypodiploidy associated with centrosome amplification. 103
Rb depletion induces centrosome amplification and different exression of mitotic genes in HCT116 tumor cells 96
PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene 95
Integrated computational and experimental approaches for the identification of new molecules with readthrough activity on premature termination codons (PTCs) in cystic fibrosis cells 92
Pyrazole[3,4-d]pyrimidine derivatives loaded into halloysite as potential CDK inhibitors 92
DNMT1 prolonged absence is a tunable cellular stress that triggers cell proliferation arrest to protect from major DNA methylation loss 91
The retinoblastoma paradigm revisited 91
OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS 86
Totale 16.258
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Categoria #
all - tutte 54.095
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 54.095
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021258 0 0 0 0 0 0 0 0 0 0 126 132
2021/20221.163 53 288 34 29 34 38 39 89 115 155 60 229
2022/20231.611 144 177 38 278 149 246 118 123 174 43 77 44
2023/20241.014 55 118 94 114 78 148 98 144 6 20 10 129
2024/20251.887 86 117 89 170 107 93 134 96 124 212 235 424
2025/20266.003 400 142 320 472 644 904 944 703 486 793 195 0
Totale 16.569