| Nome |
# |
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p14(ARF) Prevents Proliferation of Aneuploid Cells by Inducing p53-Dependent Apoptosis, file e3ad8919-12e2-da0e-e053-3705fe0a2b96
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370
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Retinoblastoma epidemiology: Does the evidence matter?, file e3ad8915-bcbc-da0e-e053-3705fe0a2b96
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319
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Simultaneous reduction of MAD2 and BUBR1 expression induces mitotic spindle alterations associated with p53 dependent cell cycle arrest and death, file e3ad8918-c1d3-da0e-e053-3705fe0a2b96
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265
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DNA demethylation caused By 5-Aza-2'-Deoxycytidine induces mitotic alterations and aneuploidy, file e3ad8919-168c-da0e-e053-3705fe0a2b96
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264
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The sea urchin sns insulator blocks CMV enhancer following integration in human cells, file e3ad8919-7600-da0e-e053-3705fe0a2b96
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251
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Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells, file e3ad8918-cb25-da0e-e053-3705fe0a2b96
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212
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Functional inactivation of pRB results in aneuploid mammalian cells after release from a mitotic block, file e3ad8919-7e8d-da0e-e053-3705fe0a2b96
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207
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NOTCH3 expression is linked to breast cancer seeding and distant metastasis, file e3ad891d-6bc7-da0e-e053-3705fe0a2b96
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204
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Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs), file e3ad8920-7277-da0e-e053-3705fe0a2b96
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160
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Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype, file e3ad8915-bcbd-da0e-e053-3705fe0a2b96
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143
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Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons, file e3ad8922-bd6e-da0e-e053-3705fe0a2b96
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142
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Caffeine boosts Ataluren's readthrough activity, file e3ad891f-f569-da0e-e053-3705fe0a2b96
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137
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P14ARF: The absence that makes the difference, file e3ad8922-bd6d-da0e-e053-3705fe0a2b96
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122
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Targeting nonsense: Optimization of 1,2,4-oxadiazole trids to rescue cftr expression and functionality in cystic fibrosis cell model systems, file e3ad8923-3ff7-da0e-e053-3705fe0a2b96
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114
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RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts, file e3ad8915-bd45-da0e-e053-3705fe0a2b96
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107
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Integrated computational and experimental approaches for the identification of new molecules with readthrough activity on premature termination codons (PTCs) in cystic fibrosis cells, file e3ad891a-5f54-da0e-e053-3705fe0a2b96
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60
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Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells, file e3ad891a-896d-da0e-e053-3705fe0a2b96
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55
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Investigating CRISPR-CAS13b as a tool for the RNA editing of CFTR mRNA with premature stop codon, file e3ad8922-874e-da0e-e053-3705fe0a2b96
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53
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Specific Irreversible Cell-Cycle Arrest and Depletion of Cancer Cells Obtained by Combining Curcumin and the Flavonoids Quercetin and Fisetin, file e62dcb36-f9ab-420e-bb18-0d204aa7e492
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52
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A new p65 isoform that bind the glucocorticoid hormone and is expressed in inflammation liver diseases and COVID-19, file e3ad8927-9f53-da0e-e053-3705fe0a2b96
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46
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Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs, file e3ad8928-1bcb-da0e-e053-3705fe0a2b96
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46
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AURKA (aurora kinase A), file e3ad8915-bd46-da0e-e053-3705fe0a2b96
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41
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Transcriptomic changes following partial depletion of cenp‐e in normal human fibroblasts, file e3ad8927-5e65-da0e-e053-3705fe0a2b96
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41
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DNMT1 depletion activates
a pathway p14ARF/TP53
controlled that induces G1 arrest
preventing DNA demethylation
and aneuploidy, file e3ad8915-f9fc-da0e-e053-3705fe0a2b96
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40
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Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells, file e3ad891a-7378-da0e-e053-3705fe0a2b96
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37
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Inhibition of FTSJ1, a tryptophan tRNA-specific 2’-O-methyltransferase as possible mechanism to readthrough premature termination codons (UGAs) of the CFTR mRNA, file 884632a1-6542-456b-b3f5-70ac56ad7e56
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36
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P015 Translational readthrough inducing drugs: a study of toxicity in mice models and in vitro safety validation of the specific readthrough process., file e3ad8928-04c8-da0e-e053-3705fe0a2b96
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36
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Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells, file e3ad891b-b4e6-da0e-e053-3705fe0a2b96
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35
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Premature termination codon 124 derivatives as a novel approach to improve the read-through of premature amber and ochre stop codons, file e3ad891a-0602-da0e-e053-3705fe0a2b96
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24
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Nonsense codons suppression. An acute toxicity study of three optimized TRIDs in murine model, safety and tolerability evaluation, file 1e5efa24-2980-40c2-bc8c-83ceb570ce7a
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20
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The tumor suppressor p14ARF hampers proliferation of aneuploid cells induced by CENP-E partial depletion, file e3ad891d-bd1d-da0e-e053-3705fe0a2b96
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19
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Derivati Ossadiazolici per il trattamento della fibrosi cistica: Readthrough di mutazioni nonsense, file e3ad891e-a938-da0e-e053-3705fe0a2b96
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18
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Site-Specific RNA Editing of Stop Mutations in the CFTR mRNA of Human Bronchial Cultured Cells, file 15d9e29a-75e7-427f-9604-f31291b873a4
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11
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Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs, file e3ad891e-cacc-da0e-e053-3705fe0a2b96
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11
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OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS, file e3ad8920-74ea-da0e-e053-3705fe0a2b96
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10
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Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives, file e3ad8919-5b34-da0e-e053-3705fe0a2b96
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9
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Aneuploid IMR90 cells induced by depletion of pRB, DNMT1 and MAD2 show a common gene expression signature, file e3ad8921-7a7c-da0e-e053-3705fe0a2b96
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8
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RNA Editing Approaches for the correction of nonsense mutation in a cell model for Cystic Fibrosis, file 7a12e278-2f20-4fd3-ae6a-cdd072e608b4
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6
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Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells., file e3ad891c-ff25-da0e-e053-3705fe0a2b96
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6
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Pyrazole[3,4-d]pyrimidine derivatives loaded into halloysite as potential CDK inhibitors, file e3ad8926-ed54-da0e-e053-3705fe0a2b96
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6
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Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening, file e3ad8919-516a-da0e-e053-3705fe0a2b96
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5
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Chromosome Instability, friend or foe: genetic and epigenetic causes in cancer, file 73d8e04d-2f41-442f-b533-38dbe212bf19
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4
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Identification of a new molecule with readthrough activity to rescue CFTR protein function, file e3ad891e-be4c-da0e-e053-3705fe0a2b96
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4
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Inhalable nano into micro dry powders for ivacaftor delivery: the role of mannitol and cysteamine as mucus-active agents, file e3ad8921-b8f8-da0e-e053-3705fe0a2b96
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4
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Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay, file e3ad891a-a2e8-da0e-e053-3705fe0a2b96
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2
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Proliferation of aneuploid cells induced by CENP-E depletion is counteracted by the p14ARFtumor suppressor, file e3ad8920-e44c-da0e-e053-3705fe0a2b96
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2
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Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs, file e3ad8923-4496-da0e-e053-3705fe0a2b96
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2
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Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution
evaluation in mice models, file eab10e10-f2d1-4769-ac85-047f57ec630f
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2
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The retinoblastoma paradigm revisited, file e3ad8915-6da4-da0e-e053-3705fe0a2b96
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1
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RNAi mediated acute depletion of Retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation, file e3ad8915-8f7a-da0e-e053-3705fe0a2b96
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1
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DNA Methyltransferase1 post-transcriptional silencing induces aneuploidy and cell cycle arrest in human cells., file e3ad8915-a1ee-da0e-e053-3705fe0a2b96
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1
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Aurora-A transcriptional silencing and Vincristine treatment show a synergistic effect in human tumor cells, file e3ad8915-bcba-da0e-e053-3705fe0a2b96
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1
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MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a P53 pathway preventing aneuploid cells propagation., file e3ad8919-42c7-da0e-e053-3705fe0a2b96
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1
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Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts, file e3ad8919-6211-da0e-e053-3705fe0a2b96
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1
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The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells., file e3ad891c-635e-da0e-e053-3705fe0a2b96
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1
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| Totale |
3.775 |