Archivio istituzionale della ricerca dell'Università degli Studi di Palermo

MELFI, Raffaella
 Distribuzione geografica
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Continente #
NA - Nord America 4.675
EU - Europa 4.188
AS - Asia 3.129
SA - Sud America 470
AF - Africa 106
Continente sconosciuto - Info sul continente non disponibili 24
OC - Oceania 14
Totale 12.606
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Nazione #
US - Stati Uniti d'America 4.578
IT - Italia 1.509
SG - Singapore 1.066
RU - Federazione Russa 903
CN - Cina 792
BR - Brasile 351
DE - Germania 325
HK - Hong Kong 300
FI - Finlandia 279
VN - Vietnam 275
PL - Polonia 210
FR - Francia 188
IN - India 172
GB - Regno Unito 165
JP - Giappone 137
IE - Irlanda 119
UA - Ucraina 108
SE - Svezia 96
NL - Olanda 78
TR - Turchia 62
CA - Canada 57
KR - Corea 54
BD - Bangladesh 51
ES - Italia 49
AR - Argentina 42
IQ - Iraq 38
BE - Belgio 33
AT - Austria 28
MX - Messico 26
CI - Costa d'Avorio 23
PT - Portogallo 21
IL - Israele 20
XK - ???statistics.table.value.countryCode.XK??? 20
ZA - Sudafrica 20
RO - Romania 19
MY - Malesia 17
PK - Pakistan 17
CL - Cile 16
CH - Svizzera 14
ID - Indonesia 14
IR - Iran 14
MA - Marocco 14
AU - Australia 13
EC - Ecuador 12
PY - Paraguay 12
UZ - Uzbekistan 12
VE - Venezuela 11
CO - Colombia 10
DZ - Algeria 10
JO - Giordania 9
KE - Kenya 9
LT - Lituania 9
SA - Arabia Saudita 9
NG - Nigeria 8
EG - Egitto 7
KZ - Kazakistan 7
RS - Serbia 7
TN - Tunisia 7
AE - Emirati Arabi Uniti 6
BO - Bolivia 6
CZ - Repubblica Ceca 6
JM - Giamaica 6
NP - Nepal 6
QA - Qatar 6
UY - Uruguay 6
GR - Grecia 5
AZ - Azerbaigian 4
KG - Kirghizistan 4
LB - Libano 4
NO - Norvegia 4
PE - Perù 4
BG - Bulgaria 3
BH - Bahrain 3
ET - Etiopia 3
LK - Sri Lanka 3
PA - Panama 3
PH - Filippine 3
PS - Palestinian Territory 3
SI - Slovenia 3
SY - Repubblica araba siriana 3
AM - Armenia 2
CY - Cipro 2
EU - Europa 2
GE - Georgia 2
HN - Honduras 2
KW - Kuwait 2
OM - Oman 2
SK - Slovacchia (Repubblica Slovacca) 2
SN - Senegal 2
TW - Taiwan 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AO - Angola 1
BN - Brunei Darussalam 1
CR - Costa Rica 1
CW - ???statistics.table.value.countryCode.CW??? 1
DK - Danimarca 1
EE - Estonia 1
GA - Gabon 1
KH - Cambogia 1
Totale 12.596
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Città #
Singapore 752
Ashburn 673
Palermo 582
San Jose 387
Fairfield 282
Hong Kong 273
Chandler 237
Zgierz 173
Ann Arbor 165
Woodbridge 152
Council Bluffs 135
Houston 133
Moscow 133
Wilmington 128
Seattle 118
Beijing 112
Dublin 109
Helsinki 107
Los Angeles 95
Tokyo 95
Hefei 94
Cambridge 90
New York 90
Hyderabad 89
Ho Chi Minh City 88
The Dalles 80
Lauterbourg 78
Medford 78
Dallas 70
Hanoi 61
Milan 60
Santa Clara 59
Rome 55
Des Moines 53
Frankfurt am Main 53
Nanjing 53
Jacksonville 52
Princeton 50
Philadelphia 47
Buffalo 39
Ludwigshafen am Rhein 37
Bremen 35
Naples 33
Catania 31
Dearborn 30
London 30
Shenyang 30
São Paulo 29
Altamura 28
Chicago 28
Munich 27
Boardman 26
Jinan 26
Amsterdam 24
Orem 24
Abidjan 23
Atlanta 23
Barcelona 23
Brussels 22
Haiphong 22
Lawrence 21
Tulsa 21
Turku 21
Warsaw 20
Changsha 19
Brooklyn 18
Clifton 18
Da Nang 18
Falkenstein 18
Izmir 18
Montreal 18
Birmingham 17
Chennai 17
Columbus 17
Redwood City 17
Rio de Janeiro 17
San Diego 17
Chikmagalūr 16
Nanchang 16
Phoenix 16
Tianjin 16
Vienna 16
Turin 15
Florence 14
Guangzhou 14
Ningbo 14
Nuremberg 14
Partanna 14
Hebei 13
Paris 13
Baghdad 12
Central 12
Curitiba 12
Denver 12
Fort Collins 12
Johannesburg 12
Tel Aviv 12
Toronto 12
Verona 12
Ankara 11
Totale 7.353
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Nome #
Tracking the invasion of the red swamp crayfish Procambarus clarkii (Girard, 1852) (Decapoda Cambaridae) in Sicily: a “citizen science” approach 333
P015 Translational readthrough inducing drugs: a study of toxicity in mice models and in vitro safety validation of the specific readthrough process. 279
Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives 277
Caffeine boosts Ataluren's readthrough activity 277
Investigating CRISPR-CAS13b as a tool for the RNA editing of CFTR mRNA with premature stop codon 261
Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay 246
Can phthalates move into the eggs of the loggerhead sea turtle Caretta caretta? The case of the nests on the Linosa Island in the Mediterranean Sea 242
AZIONE READTHROUGH DI DERIVATI DEL PTC124 SU SISTEMI MODELLO CELLULARI E IN CELLULE DI EPITELIO BRONCHIALE-FC IB3.1 (CFTR F508/W1282X ) 231
Derivati Ossadiazolici per il trattamento della fibrosi cistica: Readthrough di mutazioni nonsense 221
Constitutive Promoter Occupancy by the MBF-1 Activator and Chromatin Modification of the Developmental Regulated Sea Urchin alpha-H2A Histone Gene 220
Down regulation of early sea urchin histone H2A gene relies on cis regulative sequences located in the 5’ and 3’ regions and including the enhancer blocker sns 218
CHOMATIN DYNAMIC AND REGULATION OF GENE EXSPRESSION IN THE SEA URCHIN EMBRYO 200
Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) 198
Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening 197
Pharmacophore-Based Design of New Chemical Scaffolds as Translational Readthrough-Inducing Drugs (TRIDs) 197
Characterization of a nuclear factor associated to the chromatin of sea urchin histone genes 194
Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs 193
Ruolo delle HDAC sul silenziamento genico nell’embrione di riccio di mare 189
Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution evaluation in mice models 186
Premature termination codon 124 derivatives as a novel approach to improve the read-through of premature amber and ochre stop codons 186
NEW TRANSLATIONAL READTHROUGH INDUCING DRUGS RESCUING NONSENSE MUTATED TP53: STRATEGIES AGAINST CANCER 178
Targeting nonsense: Optimization of 1,2,4-oxadiazole trids to rescue cftr expression and functionality in cystic fibrosis cell model systems 177
Nonsense codons suppression. An acute toxicity study of three optimized TRIDs in murine model, safety and tolerability evaluation 174
Impact of Heavy Metals in Eggs and Tissues of C. caretta along the Sicilian Coast (Mediterranean Sea) 173
Potential translational readthough inducin drugs: an optimized design and synthesis of new chemical scaffolds 172
Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons 172
Promoter activity of the sea urchin (Paracentrotus lividus) nucleosomal H3 and H2A and linker H1 a-histone genes is modulated by enhancer and chromatin insulator 171
The Compass-like Locus, Exclusive to the Ambulacrarians, Encodes a Chromatin Insulator Binding Protein in the Sea Urchin Embryo 169
Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells 167
Dinamica della cromatina nella regolazione del gene con homeobox Hbox12 in P. lividus. 166
“Epigenetics of silencing of Paracentrotus lividus α-H2A gene” 165
Rescuing nonsense in cancer: recovering p53 tumor suppressor gene expression by translational readthrough inducing drugs (TRIDs) 163
Investigating the inhibition of FTSJ1 a tryptophan tRNA-specific 2’-O-methyltransferase by NV TRIDs, as a mechanism of readthrough in nonsense mutated CFTR 163
Readthrough Inducing Drugs (TRIDs) in human fibroblasts harboring the c.5047 C>T (R1683*) nonsense mutation 163
Enhancer, chromatin insulator, non-coding RNA and α-histone gene expression during embryogenesis of the sea urchin Paracentrotus lividus. 163
LA DINAMICA DELLA CROMATINA NELLA REGOLAZIONE DELL’ESPRESSIONEGENICA DELL’EMBRIONE DI RICCIO DI MARE 162
Promoting readthrough of nonsense mutations in CF mouse model: Biodistribution and efficacy of NV848 in rescuing CFTR protein expression 161
The sea urchin sns insulator blocks CMV enhancer following integration in human cells 160
Reevaluating the function of a transcription factor: MBF-1 as a sea urchin chromatin organizer ? 159
PERSONALIZED MEDICINE FIGHTING NONSENSE DISEASES: EXPLORATION OF NV MOLECULES MECHANISM OF ACTION IN PURE-LITE SYSTEM AND THEIR READTHROUGH ACTIVITY IN CHOROIDEREMIA NONSENSE MODEL 157
PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene. 153
RNA Editing Approaches for the correction of nonsense mutation in a cell model for Cystic Fibrosis 152
RESCUING P53 BY NEW TRANSLATIONAL READTHROUGH INDUCING DRUGS 151
The sea urchin histone H2A enhancer-binding protein MBF-1 is needed for maximal expression also for the H3 gene, while is buffered by the sns5 insulator on its interaction with the downstream H1 promoter. 145
Valutazione dell'azione readthorough della molecola PTC124 su sistemi modello cellulari contenenti mutazioni non senso e in cellule epiteliali bronchiali IB3.1 (delF508/W1282X) derivate da pazienti affetti da fibrosi cistica. 145
Sea urchin HSF activity in vitro and in transgenic embryos 145
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells 144
Unlocking Cellular Secrets: Charting Proteomic Frontiers in LRBA Deficiency Through the Lens of Readthrough Promoters 141
Identification of New Translational Readthrough Inducing Drugs 140
Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs 140
The genetic identity of the only Italian population of the genus Macroprotodon Guichenot, 1850 on the island of Lampedusa, Sicily 138
CFTR G542X/ G542X mouse model carrying nonsense mutations, useful tool to test the efficacy of translational readthrough-based therapy in Cystic Fibrosis 135
PTC124 DERIVATIVES AS A NOVEL APPROACH TO IMPROVE THE READTHROUGH OF PREMATURE AMBER AND OCHRE STOP CODONS 129
Uptake and photoinduced degradation of phthalic acid esters (PAEs) in Ulva lactuca highlight its potential application in environmental bioremediation 128
A precision medicine approach to primary immunodeficiency disease: Ataluren strikes nonsense mutations once again 127
Identification of a new molecule with readthrough activity to rescue CFTR protein function 127
X CONVENTION OF INVESTIGATORS IN CYSTIC FIBROSIS 124
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the readthrough of PTCs in CF cells 122
Presence and biodistribution of perfluorooctanoic acid (PFOA) in Paracentrotus lividus highlight its potential application for environmental biomonitoring 114
A precision medicine approach for nonsense mutations: study of novel small molecules for the rescue of p53 protein expression 112
Translational readthrough approach to fight nonsense in cancer: design and synthesis of new trids rescuing P53 112
Readthrough Approach Using NV Translational Readthrough-Inducing Drugs (TRIDs): A Study of the Possible Off-Target Effects on Natural Termination Codons (NTCs) on TP53 and Housekeeping Gene Expression 111
Controlled uptake of PFOA in adult specimens of Paracentrotus lividus and evaluation of gene expression in their gonads and embryos 111
Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells 109
Production of CHM R293X cell model system to study the rescue of the Rab Escort Protein-1 expression by TRIDs nonsense suppression activity 106
Beyond Nonsense: New Molecules as Precision Therapy for Rare Genetic Diseases 102
Functional characterization of the enhancer blocking element of the sea urchin early histone gene cluster reveals insulator properties and three essential cis-acting sequences 95
PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene 95
Integrated computational and experimental approaches for the identification of new molecules with readthrough activity on premature termination codons (PTCs) in cystic fibrosis cells 92
Regulation of the sea urchin early H2A histone gene expression depends on the modulator element and on sequences located near the 3' end 89
Identification of a putative GAGA factor in P. lividus embryos 89
Phylogenetic relationships of the italian populations of horseshoe whip snake hemorrhois hippocrepis (Serpentes, colubridae) 89
OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS 86
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells. 84
CFTR rescue in a G542X nonsense mouse model of cystic fibrosis: investigating the mechanism of action and activity of translational readthrough-inducing drugs 82
RNA editing applied to cystic fibrosis: RESTORE can target G542X CFTR mRNA and revert the nonsense mutation 81
Assembly of Polycomb complexes and silencing mechanisms 79
Identification of a putative regulator of early-histone gene expression of Paracentrotus lividus 76
Gene expression during early embryogenesis of sea urchin: The histone and homeobox genes 74
Site-Specific RNA Editing of Stop Mutations in the CFTR mRNA of Human Bronchial Cultured Cells 73
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites 72
Preliminary genetic characterisation of Southern Smooth Snake Coronella girondica (Serpentes, Colubridae) populations in Italy, with some considerations on their alpine distribution 71
Expression of homeobox-containing genes in the sea urchin (Parancentrotus lividus) embryo 70
Enhancer blocking activity located near the 3′ end of the sea urchin early H2A histone gene 70
Correcting CFTR mRNA splicing defects with the plant cytokine kinetin and its analogues 69
Establishment of Polycomb silencing requires a transient interaction between PC and ESC 68
Spatially restricted expression of PlOtp, a Paracentrotus lividus Orthopedia-related homeobox gene, is correlated with oral ectodermal patterning and skeletal morphogenesis in late-cleavage sea urchin embryos 62
Phylogenetic affinities of the Italian population of Eastern Montpellier snake, Malpolon insignitus (Serpentes: Lamprophiidae) 61
Homeobox-containing gene transiently expressed in a spatially restricted pattern in the early sea urchin embryo 60
Targeting Nonsense Mutations: NV848, NV914, and NV930 for REP1 protein restoration in Choroideremia 59
Homeobox genes and sea urchin development 49
null 3
Totale 13.141
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Categoria #
all - tutte 43.652
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 43.652
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021141 0 0 0 0 0 0 0 0 0 0 60 81
2021/2022767 39 157 23 35 40 24 49 67 62 89 54 128
2022/20231.170 87 113 44 142 95 161 72 72 130 120 64 70
2023/2024995 53 87 71 79 88 164 115 157 3 26 14 138
2024/20252.200 66 120 84 138 113 203 139 219 119 300 280 419
2025/20265.558 408 143 337 563 601 816 853 638 454 527 218 0
Totale 13.141