Archivio istituzionale della ricerca dell'Università degli Studi di Palermo

MELFI, Raffaella
 Distribuzione geografica
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Continente #
NA - Nord America 5.040
EU - Europa 4.250
AS - Asia 3.192
SA - Sud America 478
AF - Africa 107
Continente sconosciuto - Info sul continente non disponibili 24
OC - Oceania 20
Totale 13.111
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Nazione #
US - Stati Uniti d'America 4.909
IT - Italia 1.561
SG - Singapore 1.066
RU - Federazione Russa 903
CN - Cina 792
BR - Brasile 352
DE - Germania 325
HK - Hong Kong 302
FI - Finlandia 279
VN - Vietnam 275
PL - Polonia 211
FR - Francia 190
IN - India 173
GB - Regno Unito 165
JP - Giappone 138
IE - Irlanda 119
BD - Bangladesh 108
UA - Ucraina 108
SE - Svezia 97
NL - Olanda 79
CA - Canada 73
TR - Turchia 62
KR - Corea 54
ES - Italia 52
AR - Argentina 42
IQ - Iraq 38
BE - Belgio 33
MX - Messico 31
AT - Austria 28
CI - Costa d'Avorio 23
PT - Portogallo 23
IL - Israele 20
XK - ???statistics.table.value.countryCode.XK??? 20
ZA - Sudafrica 20
AU - Australia 19
RO - Romania 19
MY - Malesia 17
PK - Pakistan 17
CL - Cile 16
MA - Marocco 15
CH - Svizzera 14
EC - Ecuador 14
ID - Indonesia 14
IR - Iran 14
CO - Colombia 13
PY - Paraguay 12
UZ - Uzbekistan 12
VE - Venezuela 12
DZ - Algeria 10
JO - Giordania 9
KE - Kenya 9
LT - Lituania 9
SA - Arabia Saudita 9
NG - Nigeria 8
QA - Qatar 8
EG - Egitto 7
JM - Giamaica 7
KZ - Kazakistan 7
RS - Serbia 7
TN - Tunisia 7
AE - Emirati Arabi Uniti 6
BO - Bolivia 6
CZ - Repubblica Ceca 6
NP - Nepal 6
UY - Uruguay 6
GR - Grecia 5
PE - Perù 5
AZ - Azerbaigian 4
HN - Honduras 4
KG - Kirghizistan 4
LB - Libano 4
NO - Norvegia 4
BG - Bulgaria 3
BH - Bahrain 3
CR - Costa Rica 3
ET - Etiopia 3
LK - Sri Lanka 3
PA - Panama 3
PH - Filippine 3
PR - Porto Rico 3
PS - Palestinian Territory 3
SI - Slovenia 3
SV - El Salvador 3
SY - Repubblica araba siriana 3
AM - Armenia 2
CY - Cipro 2
EU - Europa 2
GE - Georgia 2
KW - Kuwait 2
NI - Nicaragua 2
OM - Oman 2
SK - Slovacchia (Repubblica Slovacca) 2
SN - Senegal 2
TT - Trinidad e Tobago 2
TW - Taiwan 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AO - Angola 1
BN - Brunei Darussalam 1
CW - ???statistics.table.value.countryCode.CW??? 1
Totale 13.099
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Città #
Singapore 752
Ashburn 703
Palermo 591
San Jose 492
Fairfield 282
Hong Kong 275
Chandler 237
Zgierz 173
Ann Arbor 165
Woodbridge 153
Council Bluffs 136
Houston 135
Moscow 133
Wilmington 128
Seattle 118
Beijing 112
Dublin 109
Helsinki 107
Los Angeles 102
Tokyo 96
New York 95
Hefei 94
Cambridge 91
Hyderabad 89
Ho Chi Minh City 88
The Dalles 82
Lauterbourg 78
Medford 78
Dallas 75
Santa Clara 67
Milan 65
Hanoi 61
Rome 60
Des Moines 53
Frankfurt am Main 53
Nanjing 53
Jacksonville 52
Princeton 50
Philadelphia 49
Boardman 48
Buffalo 40
Naples 38
Ludwigshafen am Rhein 37
Bremen 35
Catania 31
Chicago 31
Dearborn 30
London 30
Shenyang 30
São Paulo 29
Altamura 28
Munich 27
Jinan 26
Amsterdam 24
Atlanta 24
Orem 24
Abidjan 23
Barcelona 23
Brussels 22
Haiphong 22
Lawrence 21
Tulsa 21
Turku 21
Warsaw 20
Brooklyn 19
Changsha 19
Montreal 19
Birmingham 18
Clifton 18
Columbus 18
Da Nang 18
Falkenstein 18
Izmir 18
Rio de Janeiro 18
Chennai 17
Phoenix 17
Redwood City 17
San Diego 17
Chikmagalūr 16
Nanchang 16
Tianjin 16
Toronto 16
Vienna 16
Turin 15
Florence 14
Guangzhou 14
Ningbo 14
Nuremberg 14
Partanna 14
Denver 13
Hebei 13
Paris 13
Baghdad 12
Central 12
Curitiba 12
Fort Collins 12
Johannesburg 12
Tel Aviv 12
Verona 12
Ankara 11
Totale 7.587
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Nome #
Tracking the invasion of the red swamp crayfish Procambarus clarkii (Girard, 1852) (Decapoda Cambaridae) in Sicily: a “citizen science” approach 337
Caffeine boosts Ataluren's readthrough activity 284
P015 Translational readthrough inducing drugs: a study of toxicity in mice models and in vitro safety validation of the specific readthrough process. 282
Enhancement of premature stop codon readthrough in the CFTR gene by Ataluren (PTC124) derivatives 280
Investigating CRISPR-CAS13b as a tool for the RNA editing of CFTR mRNA with premature stop codon 271
Toward a Rationale for the PTC124 (Ataluren) Promoted Readthrough of Premature Stop Codons: A Computational Approach and GFP-Reporter Cell-Based Assay 250
Can phthalates move into the eggs of the loggerhead sea turtle Caretta caretta? The case of the nests on the Linosa Island in the Mediterranean Sea 246
AZIONE READTHROUGH DI DERIVATI DEL PTC124 SU SISTEMI MODELLO CELLULARI E IN CELLULE DI EPITELIO BRONCHIALE-FC IB3.1 (CFTR F508/W1282X ) 237
Down regulation of early sea urchin histone H2A gene relies on cis regulative sequences located in the 5’ and 3’ regions and including the enhancer blocker sns 228
Derivati Ossadiazolici per il trattamento della fibrosi cistica: Readthrough di mutazioni nonsense 228
Constitutive Promoter Occupancy by the MBF-1 Activator and Chromatin Modification of the Developmental Regulated Sea Urchin alpha-H2A Histone Gene 222
Nonsense codons suppression. An acute toxicity study of three optimized TRIDs in murine model, safety and tolerability evaluation 209
CHOMATIN DYNAMIC AND REGULATION OF GENE EXSPRESSION IN THE SEA URCHIN EMBRYO 204
Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) 204
Pharmacophore-Based Design of New Chemical Scaffolds as Translational Readthrough-Inducing Drugs (TRIDs) 200
PERSONALIZED MEDICINE FIGHTING NONSENSE DISEASES: EXPLORATION OF NV MOLECULES MECHANISM OF ACTION IN PURE-LITE SYSTEM AND THEIR READTHROUGH ACTIVITY IN CHOROIDEREMIA NONSENSE MODEL 199
Exploring the readthrough of nonsense mutations by non-acidic Ataluren analogues selected by ligand-based virtual screening 199
Characterization of a nuclear factor associated to the chromatin of sea urchin histone genes 197
Rescuing the CFTR protein function: Introducing 1,3,4-oxadiazoles as translational readthrough inducing drugs 197
Ruolo delle HDAC sul silenziamento genico nell’embrione di riccio di mare 193
Premature termination codon 124 derivatives as a novel approach to improve the read-through of premature amber and ochre stop codons 192
Translational Readthrough Inducing Drugs (TRIDs): a study of biodistribution evaluation in mice models 189
NEW TRANSLATIONAL READTHROUGH INDUCING DRUGS RESCUING NONSENSE MUTATED TP53: STRATEGIES AGAINST CANCER 186
Targeting nonsense: Optimization of 1,2,4-oxadiazole trids to rescue cftr expression and functionality in cystic fibrosis cell model systems 180
Impact of Heavy Metals in Eggs and Tissues of C. caretta along the Sicilian Coast (Mediterranean Sea) 178
Potential translational readthough inducin drugs: an optimized design and synthesis of new chemical scaffolds 176
Promoting readthrough of nonsense mutations in CF mouse model: Biodistribution and efficacy of NV848 in rescuing CFTR protein expression 176
Investigating REPAIRv2 as a Tool to Edit CFTR mRNA with Premature Stop Codons 176
Promoter activity of the sea urchin (Paracentrotus lividus) nucleosomal H3 and H2A and linker H1 a-histone genes is modulated by enhancer and chromatin insulator 175
The Compass-like Locus, Exclusive to the Ambulacrarians, Encodes a Chromatin Insulator Binding Protein in the Sea Urchin Embryo 175
Rescuing nonsense in cancer: recovering p53 tumor suppressor gene expression by translational readthrough inducing drugs (TRIDs) 173
Optimization of a new lead promoting the readthrough of the nonsense mutations for CFTR rescue in human CF cells 171
Dinamica della cromatina nella regolazione del gene con homeobox Hbox12 in P. lividus. 170
“Epigenetics of silencing of Paracentrotus lividus α-H2A gene” 169
Enhancer, chromatin insulator, non-coding RNA and α-histone gene expression during embryogenesis of the sea urchin Paracentrotus lividus. 167
LA DINAMICA DELLA CROMATINA NELLA REGOLAZIONE DELL’ESPRESSIONEGENICA DELL’EMBRIONE DI RICCIO DI MARE 166
Investigating the inhibition of FTSJ1 a tryptophan tRNA-specific 2’-O-methyltransferase by NV TRIDs, as a mechanism of readthrough in nonsense mutated CFTR 165
Readthrough Inducing Drugs (TRIDs) in human fibroblasts harboring the c.5047 C>T (R1683*) nonsense mutation 165
Reevaluating the function of a transcription factor: MBF-1 as a sea urchin chromatin organizer ? 165
The sea urchin sns insulator blocks CMV enhancer following integration in human cells 165
PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene. 159
RNA Editing Approaches for the correction of nonsense mutation in a cell model for Cystic Fibrosis 158
RESCUING P53 BY NEW TRANSLATIONAL READTHROUGH INDUCING DRUGS 157
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells 149
Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs 149
The sea urchin histone H2A enhancer-binding protein MBF-1 is needed for maximal expression also for the H3 gene, while is buffered by the sns5 insulator on its interaction with the downstream H1 promoter. 148
Valutazione dell'azione readthorough della molecola PTC124 su sistemi modello cellulari contenenti mutazioni non senso e in cellule epiteliali bronchiali IB3.1 (delF508/W1282X) derivate da pazienti affetti da fibrosi cistica. 147
Sea urchin HSF activity in vitro and in transgenic embryos 146
CFTR G542X/ G542X mouse model carrying nonsense mutations, useful tool to test the efficacy of translational readthrough-based therapy in Cystic Fibrosis 142
Unlocking Cellular Secrets: Charting Proteomic Frontiers in LRBA Deficiency Through the Lens of Readthrough Promoters 142
The genetic identity of the only Italian population of the genus Macroprotodon Guichenot, 1850 on the island of Lampedusa, Sicily 142
Identification of New Translational Readthrough Inducing Drugs 141
A precision medicine approach to primary immunodeficiency disease: Ataluren strikes nonsense mutations once again 133
PTC124 DERIVATIVES AS A NOVEL APPROACH TO IMPROVE THE READTHROUGH OF PREMATURE AMBER AND OCHRE STOP CODONS 132
Uptake and photoinduced degradation of phthalic acid esters (PAEs) in Ulva lactuca highlight its potential application in environmental bioremediation 129
Identification of a new molecule with readthrough activity to rescue CFTR protein function 129
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the readthrough of PTCs in CF cells 128
X CONVENTION OF INVESTIGATORS IN CYSTIC FIBROSIS 126
Correcting CFTR mRNA splicing defects with the plant cytokine kinetin and its analogues 125
A precision medicine approach for nonsense mutations: study of novel small molecules for the rescue of p53 protein expression 118
Translational readthrough approach to fight nonsense in cancer: design and synthesis of new trids rescuing P53 117
Presence and biodistribution of perfluorooctanoic acid (PFOA) in Paracentrotus lividus highlight its potential application for environmental biomonitoring 114
Readthrough Approach Using NV Translational Readthrough-Inducing Drugs (TRIDs): A Study of the Possible Off-Target Effects on Natural Termination Codons (NTCs) on TP53 and Housekeeping Gene Expression 113
Controlled uptake of PFOA in adult specimens of Paracentrotus lividus and evaluation of gene expression in their gonads and embryos 112
Novel molecules for the readthrough of PTCs in biological model systems and in cystic fibrosis cells 112
Production of CHM R293X cell model system to study the rescue of the Rab Escort Protein-1 expression by TRIDs nonsense suppression activity 109
Beyond Nonsense: New Molecules as Precision Therapy for Rare Genetic Diseases 105
PTC124 derivatives as a novel approach to improve the readthrough of premature stop codons in the CFTR gene 101
Functional characterization of the enhancer blocking element of the sea urchin early histone gene cluster reveals insulator properties and three essential cis-acting sequences 99
RNA editing applied to cystic fibrosis: RESTORE can target G542X CFTR mRNA and revert the nonsense mutation 97
Integrated computational and experimental approaches for the identification of new molecules with readthrough activity on premature termination codons (PTCs) in cystic fibrosis cells 95
Regulation of the sea urchin early H2A histone gene expression depends on the modulator element and on sequences located near the 3' end 94
Identification of a putative GAGA factor in P. lividus embryos 92
Phylogenetic relationships of the italian populations of horseshoe whip snake hemorrhois hippocrepis (Serpentes, colubridae) 92
OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS 88
CFTR rescue in a G542X nonsense mouse model of cystic fibrosis: investigating the mechanism of action and activity of translational readthrough-inducing drugs 87
Identification and validation of novel molecules obtained by integrated computational and experimental approaches for the read-through of PTCs in CF cells. 87
Assembly of Polycomb complexes and silencing mechanisms 81
Site-Specific RNA Editing of Stop Mutations in the CFTR mRNA of Human Bronchial Cultured Cells 77
Gene expression during early embryogenesis of sea urchin: The histone and homeobox genes 77
Identification of a putative regulator of early-histone gene expression of Paracentrotus lividus 77
Preliminary genetic characterisation of Southern Smooth Snake Coronella girondica (Serpentes, Colubridae) populations in Italy, with some considerations on their alpine distribution 75
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites 73
Expression of homeobox-containing genes in the sea urchin (Parancentrotus lividus) embryo 72
Enhancer blocking activity located near the 3′ end of the sea urchin early H2A histone gene 71
Homeobox-containing gene transiently expressed in a spatially restricted pattern in the early sea urchin embryo 70
Establishment of Polycomb silencing requires a transient interaction between PC and ESC 68
Spatially restricted expression of PlOtp, a Paracentrotus lividus Orthopedia-related homeobox gene, is correlated with oral ectodermal patterning and skeletal morphogenesis in late-cleavage sea urchin embryos 66
Targeting Nonsense Mutations: NV848, NV914, and NV930 for REP1 protein restoration in Choroideremia 63
Phylogenetic affinities of the Italian population of Eastern Montpellier snake, Malpolon insignitus (Serpentes: Lamprophiidae) 62
Homeobox genes and sea urchin development 51
null 3
Totale 13.646
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Categoria #
all - tutte 45.791
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 45.791
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022767 39 157 23 35 40 24 49 67 62 89 54 128
2022/20231.170 87 113 44 142 95 161 72 72 130 120 64 70
2023/2024995 53 87 71 79 88 164 115 157 3 26 14 138
2024/20252.200 66 120 84 138 113 203 139 219 119 300 280 419
2025/20265.875 408 143 337 563 601 816 853 638 454 527 257 278
2026/2027188 188 0 0 0 0 0 0 0 0 0 0 0
Totale 13.646