Background: Cerebral Amyloid Angiopathy has been indicated as an importantcause of spontaneous non-hypertensive intracerebral haemorrhage (ICH).Aims: to analyze the presence of β-amyloid deposit in the temporal artery ofconsecutive patients with ICH in comparison to control subjects and its relation toAPO-E haplotype frequency.Methods: We enrolled consecutive patients admitted to Neurosurgery Ward ofUniversity Hospital "P. Giaccone" of Palermo with a diagnosis of spontaneous nonhypertensive ICH and as control 12 subjects without brain haemorrhage. Biopsyof superficial temporal artery has been performed and β-amyloid deposit wasquantified.Results: Among 25 subjects with ICH, 10 (40%) had APOE epsilon 2 allele andamong these subjects 7 (70%) showed amyloid accumulation on temporal arteryspecimens, 8 (32%) subjects had APOE epsilon 3 allele and among these subjectsonly 2 (25%) showed amyloid accumulation on temporal artery specimens, whereas7 (28%) had APOE epsilon 4 allele and of these, 7 (100%) showed amyloidaccumulation on temporal artery specimens. At multivariable logistic regressionanalysis for the presence of amyloid, predictive factors for the presence of amyloidin temporal artery biopsies were: age, hypertension, intralobar site of haemorrhage,APOE epsilon 2 and APOE epsilon 4 alleles.Discussion: Our findings of a higher frequency of amyloid deposition in temporalartery specimens in subjects with spontaneous intracerebral haemorrhage indicatea possible role of temporal artery as a possible diagnostic site of biopsy in subjectsat high risk to develop intracranial haemorrhage related to Cerebral AmyloidAngiopathy.

Tuttolomondo A., Maugeri R., Orlando E., Giannone G., Ciccia F., Rizzo A., et al. (2018). β-amyloid wall deposit of temporal artery in subjects with spontaneous intracerebral haemorrhage. ONCOTARGET, 9(78), 34699-34707 [10.18632/oncotarget.26165].

β-amyloid wall deposit of temporal artery in subjects with spontaneous intracerebral haemorrhage

Giannone G.;Ciccia F.;Di Raimondo D.;Simonetta I.;Portelli F.;Corpora F.;Iacopino D.;
2018

Abstract

Background: Cerebral Amyloid Angiopathy has been indicated as an importantcause of spontaneous non-hypertensive intracerebral haemorrhage (ICH).Aims: to analyze the presence of β-amyloid deposit in the temporal artery ofconsecutive patients with ICH in comparison to control subjects and its relation toAPO-E haplotype frequency.Methods: We enrolled consecutive patients admitted to Neurosurgery Ward ofUniversity Hospital "P. Giaccone" of Palermo with a diagnosis of spontaneous nonhypertensive ICH and as control 12 subjects without brain haemorrhage. Biopsyof superficial temporal artery has been performed and β-amyloid deposit wasquantified.Results: Among 25 subjects with ICH, 10 (40%) had APOE epsilon 2 allele andamong these subjects 7 (70%) showed amyloid accumulation on temporal arteryspecimens, 8 (32%) subjects had APOE epsilon 3 allele and among these subjectsonly 2 (25%) showed amyloid accumulation on temporal artery specimens, whereas7 (28%) had APOE epsilon 4 allele and of these, 7 (100%) showed amyloidaccumulation on temporal artery specimens. At multivariable logistic regressionanalysis for the presence of amyloid, predictive factors for the presence of amyloidin temporal artery biopsies were: age, hypertension, intralobar site of haemorrhage,APOE epsilon 2 and APOE epsilon 4 alleles.Discussion: Our findings of a higher frequency of amyloid deposition in temporalartery specimens in subjects with spontaneous intracerebral haemorrhage indicatea possible role of temporal artery as a possible diagnostic site of biopsy in subjectsat high risk to develop intracranial haemorrhage related to Cerebral AmyloidAngiopathy.
Settore MED/27 - Neurochirurgia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205179/pdf/oncotarget-09-34699.pdf
Tuttolomondo A., Maugeri R., Orlando E., Giannone G., Ciccia F., Rizzo A., et al. (2018). β-amyloid wall deposit of temporal artery in subjects with spontaneous intracerebral haemorrhage. ONCOTARGET, 9(78), 34699-34707 [10.18632/oncotarget.26165].
File in questo prodotto:
File Dimensione Formato  
Beta amiloid.pdf

accesso aperto

Tipologia: Versione Editoriale
Dimensione 1.02 MB
Formato Adobe PDF
1.02 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/484274
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 2
  • ???jsp.display-item.citation.isi??? ND
social impact