Objective â Methemoglobinemia (MetHb) is a rare congenital or acquired cause of infantile cyanosis. We examined the role of MetHb in a neonatal intensive care unit (NICU). Study Design â A retrospective observational study was conducted reviewing blood gas analyses of hospitalized newborns over a 2-year period. MetHb-positive patients (MetHb >1.8%) were matched with a control group for gestational age, weight, disease, and illness severity at admission. Maternal, neonatal, clinical, and laboratory parameters were collected and analyzed in both groups. Results â MetHb incidence was 6%. The mean MetHb in the case group was 7.2%, and the first positive samples were observed at a mean of 22 days of life, 6 days prior to clinical or culture-proven sepsis. We identified low maternal age (31 vs. 34 years; p = 0.038), sepsis (90 vs. 45%; p = 0.022), and protracted parenteral nutrition (46 vs. 23 days; p = 0.013) as risk factors for MetHb, and early minimal enteral feeding as protective factor (12th vs. 9th day; p = 0.038). Conclusion â MetHb has a high occurrence in NICU and can be a helpful prognostic indicator of an infectious process. Understanding and prompt identification of MetHb can allow pediatricians to implement a life-saving therapy.

Schierz I.A.M., Pinello G., Piro E., Giuffre M., Corsello G. (2019). Methemoglobinemia Associated with Late-Onset Neonatal Sepsis: A Single-Center Experience. AMERICAN JOURNAL OF PERINATOLOGY, 36(14), 1510-1513 [10.1055/s-0039-1678556].

Methemoglobinemia Associated with Late-Onset Neonatal Sepsis: A Single-Center Experience

Schierz I. A. M.
;
Pinello G.;Piro E.;Giuffre M.;Corsello G.
2019-01-01

Abstract

Objective â Methemoglobinemia (MetHb) is a rare congenital or acquired cause of infantile cyanosis. We examined the role of MetHb in a neonatal intensive care unit (NICU). Study Design â A retrospective observational study was conducted reviewing blood gas analyses of hospitalized newborns over a 2-year period. MetHb-positive patients (MetHb >1.8%) were matched with a control group for gestational age, weight, disease, and illness severity at admission. Maternal, neonatal, clinical, and laboratory parameters were collected and analyzed in both groups. Results â MetHb incidence was 6%. The mean MetHb in the case group was 7.2%, and the first positive samples were observed at a mean of 22 days of life, 6 days prior to clinical or culture-proven sepsis. We identified low maternal age (31 vs. 34 years; p = 0.038), sepsis (90 vs. 45%; p = 0.022), and protracted parenteral nutrition (46 vs. 23 days; p = 0.013) as risk factors for MetHb, and early minimal enteral feeding as protective factor (12th vs. 9th day; p = 0.038). Conclusion â MetHb has a high occurrence in NICU and can be a helpful prognostic indicator of an infectious process. Understanding and prompt identification of MetHb can allow pediatricians to implement a life-saving therapy.
https://www.thieme.de/de/american-journal-perinatology/journal-information-9405.htm
Schierz I.A.M., Pinello G., Piro E., Giuffre M., Corsello G. (2019). Methemoglobinemia Associated with Late-Onset Neonatal Sepsis: A Single-Center Experience. AMERICAN JOURNAL OF PERINATOLOGY, 36(14), 1510-1513 [10.1055/s-0039-1678556].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/401730
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