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EnglishBackground: Congenitalpelvicskeletalanomalies(CPSA)mayappearasisolateddefectsorinassociationwith otheranomalieslikecongenitalmalformationsofthedigestivesystem(CMDS).MinorCPSAinnon-syndromic patientsareoftenoverlooked. WeaimedtoassessthefrequencyofCPSAinnewbornswithCMDStoreviewthediagnosticapproaches. Study design: A retrospective review of medical records of 201 newborns who underwent X-rays for different neonatalindicationswasconducted.In122patientsCMDSwerediagnosedandclassifiedaccordingtotheICD10classification;79non-CMDSpatientsactedascontrols.PelvicskeletalsegmentswereexaminedbyX-rays. Results: Patients with CMDS, showed a higher risk of CPSA (Odds ratio 2.89; 95% CI 1.34 6.23) and other associatedmalformationsincomparisontonon-CMDSpatients.NewbornswithmalformationsofthelargeintestinehavethehighestriskofadjacentCPSA(48%),asitisadevelopmentaldefectoriginatingfromthesame somite.Inadditiontoskeletalagenesis/hypoplasia,wereporteddysmorphicandbifidvertebras,tridentileum, andelongatedneuralarches. Conclusions: ThehighincidenceofCPSAinCMDSsuggestsperformingaroutineradiographicpelvicevaluation in cases of CMDS in order to identify complex phenotypes that could originate from the same developmental field.
| Data di pubblicazione: | 2020 |
| Titolo: | Congenital pelvic skeletal anomalies: Clinical and radiographic evaluation of newborns with gastrointestinal malformation |
| Autori: | |
| Citazione: | Schierz, I., Pinello, G., Piro, E., Giuffre, M., Cimador, M., & Corsello, G. (2020). Congenital pelvic skeletal anomalies: Clinical and radiographic evaluation of newborns with gastrointestinal malformation. EARLY HUMAN DEVELOPMENT. |
| Rivista: | |
| Digital Object Identifier (DOI): | 10.1016/j.earlhumdev.2019.104945 |
| Abstract: | Background: Congenitalpelvicskeletalanomalies(CPSA)mayappearasisolateddefectsorinassociationwith otheranomalieslikecongenitalmalformationsofthedigestivesystem(CMDS).MinorCPSAinnon-syndromic patientsareoftenoverlooked. WeaimedtoassessthefrequencyofCPSAinnewbornswithCMDStoreviewthediagnosticapproaches. Study design: A retrospective review of medical records of 201 newborns who underwent X-rays for different neonatalindicationswasconducted.In122patientsCMDSwerediagnosedandclassifiedaccordingtotheICD10classification;79non-CMDSpatientsactedascontrols.PelvicskeletalsegmentswereexaminedbyX-rays. Results: Patients with CMDS, showed a higher risk of CPSA (Odds ratio 2.89; 95% CI 1.34 6.23) and other associatedmalformationsincomparisontonon-CMDSpatients.NewbornswithmalformationsofthelargeintestinehavethehighestriskofadjacentCPSA(48%),asitisadevelopmentaldefectoriginatingfromthesame somite.Inadditiontoskeletalagenesis/hypoplasia,wereporteddysmorphicandbifidvertebras,tridentileum, andelongatedneuralarches. Conclusions: ThehighincidenceofCPSAinCMDSsuggestsperformingaroutineradiographicpelvicevaluation in cases of CMDS in order to identify complex phenotypes that could originate from the same developmental field. |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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