AIM: To evaluate the predictive role of hs-CRP and fibrinogen for cardio- and cerebrovascular events in a population of patients with type 2 diabetes. METHODS: We studied 156 patients with type 2 diabetes, mean age 66+10 years, and 156 sex and age matched control subjects. Patients underwent physical examination, EKG, measurement of body mass index and blood pressure. A blood sample was drawn to evaluate glycaemia, total and HDL/LDL cholesterol, triglycerides, high sensitive C-reactive protein (hs-CRP), fibrinogen. Finally, patients underwent an ecocolordoppler examination of the common carotid arteries until the bifurcation. In a follow-up of 5+/-1.2 years we evaluated the following events: transient ischemic attack, ischemic stroke, stable or unstable angina, acute myocardial infarction, critical limb ischemia and cardiovascular death. RESULTS: During the follow-up the prevalence of fatal (p<0.05) and non fatal events (p<0.0001) was higher in patients with diabetes in comparison with controls. The variables independently associated with non fatal events were: fibrinogen (p<0.0001), presence of asymptomatic carotid lesion (p<0.005), obesity (p<0.05) and plasma levels of hs-CRP (p<0.05), while fibrinogen (p<0.001) and age were (p<0.05) independently associated with fatal events. CONCLUSION: Our data show that in patients with diabetes mellitus, that in the follow-up the presence of high plasma levels of hs-CRP and fibrinogen are predictive for fatal or non fatal events.

COPPOLA G, CORRADO E, MURATORI I, TANTILLO R, VITALE G, LO COCO L, et al. (2006). INCREASED LEVELS OF C-REACTIVE PROTEIN AND FIBRINOGEN INFLUENCE THE RISK OF VASCULAR EVENTS IN PATIENTS WITH NIDDM. INTERNATIONAL JOURNAL OF CARDIOLOGY, 106(1), 16-20 [10.1016/j.ijcard.2004.12.051].

INCREASED LEVELS OF C-REACTIVE PROTEIN AND FIBRINOGEN INFLUENCE THE RISK OF VASCULAR EVENTS IN PATIENTS WITH NIDDM

COPPOLA, Giuseppe;CORRADO, Egle;MURATORI, Ida Maria;TANTILLO, Rosalba;LO COCO, Lucio;NOVO, Salvatore
2006

Abstract

AIM: To evaluate the predictive role of hs-CRP and fibrinogen for cardio- and cerebrovascular events in a population of patients with type 2 diabetes. METHODS: We studied 156 patients with type 2 diabetes, mean age 66+10 years, and 156 sex and age matched control subjects. Patients underwent physical examination, EKG, measurement of body mass index and blood pressure. A blood sample was drawn to evaluate glycaemia, total and HDL/LDL cholesterol, triglycerides, high sensitive C-reactive protein (hs-CRP), fibrinogen. Finally, patients underwent an ecocolordoppler examination of the common carotid arteries until the bifurcation. In a follow-up of 5+/-1.2 years we evaluated the following events: transient ischemic attack, ischemic stroke, stable or unstable angina, acute myocardial infarction, critical limb ischemia and cardiovascular death. RESULTS: During the follow-up the prevalence of fatal (p<0.05) and non fatal events (p<0.0001) was higher in patients with diabetes in comparison with controls. The variables independently associated with non fatal events were: fibrinogen (p<0.0001), presence of asymptomatic carotid lesion (p<0.005), obesity (p<0.05) and plasma levels of hs-CRP (p<0.05), while fibrinogen (p<0.001) and age were (p<0.05) independently associated with fatal events. CONCLUSION: Our data show that in patients with diabetes mellitus, that in the follow-up the presence of high plasma levels of hs-CRP and fibrinogen are predictive for fatal or non fatal events.
COPPOLA G, CORRADO E, MURATORI I, TANTILLO R, VITALE G, LO COCO L, et al. (2006). INCREASED LEVELS OF C-REACTIVE PROTEIN AND FIBRINOGEN INFLUENCE THE RISK OF VASCULAR EVENTS IN PATIENTS WITH NIDDM. INTERNATIONAL JOURNAL OF CARDIOLOGY, 106(1), 16-20 [10.1016/j.ijcard.2004.12.051].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/32485
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