Purpose: The purpose of our retrospective study was to assess the incidence of osteonecrosis in patients who received different chemotherapies. Methods and Materials: We evaluated the Whole Body Magnetic Resonance (WB-MRI) scans performed on 42 patients with Hodgkin Lymphoma treated by three chemotherapy regimens (6 ABVD, 2 ABVD + 4 BEACOPP, 2 ABVD + 8 BEACOPP), excluding the patients with main risk factors for osteonecrosis. Results: Six out of 7 patients (85.7%) who received 8 BEACOPP and 1 out of 5 patients (20%) treated by 4 BEACOPP presented osteonecrosis, with a statistically significant difference of frequency between the two groups of patients (p<0.05); no injury has been reported in patients treated by only ABVD. Among a total of 48 osteonecrotic lesions observed, the 47.9% were detected in the knee; multifocal osteonecrosis were detected in 6 out of 7 patients (85.7%). Conclusion: The development of osteonecrosis seems to be strictly related to the chemotherapy protocol adopted and the number of cycles received, strengthening the hypothesis of a correlation between the dose of corticosteroids included in the BEACOPP scheme and this complication. WB-MRI can be considered as a helpful tool that allows to early detect osteonecrotic lesions in patients treated with corticosteroids.

Albano, D., Patti, C., La Grutta, L., Grassedonio, E., Mulè, A., Lagalla, R., et al. (2016). Osteonecrosis detected by whole body magnetic resonance (WB-MRI) in patients with Hodgkin lymphoma treated by BEACOPP. In Whole body imaging.

Osteonecrosis detected by whole body magnetic resonance (WB-MRI) in patients with Hodgkin lymphoma treated by BEACOPP

ALBANO, Domenico;LA GRUTTA, Ludovico;GRASSEDONIO, Emanuele;LAGALLA, Roberto;MIDIRI, Massimo;GALIA, Massimo
2016-01-01

Abstract

Purpose: The purpose of our retrospective study was to assess the incidence of osteonecrosis in patients who received different chemotherapies. Methods and Materials: We evaluated the Whole Body Magnetic Resonance (WB-MRI) scans performed on 42 patients with Hodgkin Lymphoma treated by three chemotherapy regimens (6 ABVD, 2 ABVD + 4 BEACOPP, 2 ABVD + 8 BEACOPP), excluding the patients with main risk factors for osteonecrosis. Results: Six out of 7 patients (85.7%) who received 8 BEACOPP and 1 out of 5 patients (20%) treated by 4 BEACOPP presented osteonecrosis, with a statistically significant difference of frequency between the two groups of patients (p<0.05); no injury has been reported in patients treated by only ABVD. Among a total of 48 osteonecrotic lesions observed, the 47.9% were detected in the knee; multifocal osteonecrosis were detected in 6 out of 7 patients (85.7%). Conclusion: The development of osteonecrosis seems to be strictly related to the chemotherapy protocol adopted and the number of cycles received, strengthening the hypothesis of a correlation between the dose of corticosteroids included in the BEACOPP scheme and this complication. WB-MRI can be considered as a helpful tool that allows to early detect osteonecrotic lesions in patients treated with corticosteroids.
2016
Whole Body Imaging; Magnetic Resonance; Lymphoma; BEACOPP; Osteonecrosis
Albano, D., Patti, C., La Grutta, L., Grassedonio, E., Mulè, A., Lagalla, R., et al. (2016). Osteonecrosis detected by whole body magnetic resonance (WB-MRI) in patients with Hodgkin lymphoma treated by BEACOPP. In Whole body imaging.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/204407
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