Cold-active molecules for a sustainable preservation and restoration of historic-artistic manufacts

In the last decades biotechnology research provides sustainable alternatives to traditional procedures for preventive preservation of cultural assets. Recently, bioactive molecules (BMs) isolated from marine invertebrate organisms have been isolated and tested for bioremoval of protein layers (BMP) or to controlling microbial colonization (BMA), acting at temperature lower than 30°C. The Protease or Antimicrobial activity was tested on ad hoc assembled specimens and on different historic-artistic manufacts. In bio-removing protocol BMP molecules were applied as gelled solutions, in order to guarantees a selective action, respectful of constitutive materials and manufact integrity. Peculiarity of Protease bioactive molecules is the temperature of action, lower than 30°C. Instead, BMAs molecules have been tested to control bacteria and fungi colonization in laboratory specimens. In our hypothesis these novel molecules provide an important contribution to the development of innovative protocols safe both for the environment and conservator health, representing a valid alternative to traditional methods according to the preventive conservation and "Minimal Intervention" concept in restoration procedures.