Diabetes have been shown to have higher mortality than people without diabetes. On this basis, the aim of our study was to evaluate the possible role of diabetic foot as a cardiovascular risk marker in patients with type 2 diabetes mellitus. We enrolled 102 consecutive patients with type 2 diabetes mellitus with diabetic foot and 123 patients with type 2 diabetes mellitus without limb lesions to compare the prevalence of main cardiovascular risk factors, subclinical cardiovascular disease, previous cardiovascular morbidity, and incidence of new vascular events on a 5-year follow-up. Diabetic patients with diabetic foot were more likely to have a higher prevalence of cardiovascular risk factors such as hypercholesterolemia, hypertriglyceridemia, hyperuricemia, and microalbuminuria or proteinuria, a higher prevalence of a previous cardiovascular morbidity (coronary artery disease, transient ischemic attack/ischemic stroke, diabetic retinopathy), and a higher prevalence of subclinical cardiovascular disease. Furthermore, diabetic patients with foot ulceration showed, on a 5-year follow-up, a higher incidence of new-onset vascular events (coronary artery disease, transient ischemic attack/ischemic stroke, diabetic retinopathy). At multivariate analysis, duration of diabetes, age, hemoglobin A1c, and DFS maintained a significant association with cardiovascular morbidity; but DFS presence showed the highest hazard ratio.
|Data di pubblicazione:||2008|
|Titolo:||Cardiovascular risk profile and morbidity in subjects affected by type 2 diabetes mellitus with and without diabetic foot|
|Autori:||PINTO, A; TUTTOLOMONDO, A; DI RAIMONDO, D; FERNANDEZ, P; LA PLACA, S; DI GATI, M; LICATA, G|
|Tipologia:||Articolo su rivista|
|Citazione:||PINTO, A., TUTTOLOMONDO, A., DI RAIMONDO, D., FERNANDEZ, P., LA PLACA, S., DI GATI, M., et al. (2008). Cardiovascular risk profile and morbidity in subjects affected by type 2 diabetes mellitus with and without diabetic foot. METABOLISM, CLINICAL AND EXPERIMENTAL, 57(5):, 676--82.|
|Appare nelle tipologie:||01 - Articolo su rivista|