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EnglishThe impairment of humoral immune response in elderly humans has been extensively demonstrated. We have reported the increase of memory B cells (IgG+IgD−CD27−, double negative, DN) population in the elderly, in which there is also a typical inflammatory micro-environment. In order to evaluate whether this pro-inflammatory status could influence the trafficking phenotype of naïve/memory B cells, we have assessed the expression of CCR7, CCR6, CXCR3, CXCR4, CXCR5 and CD62L on naïve/memory B cell subpopulations in young and elderly subjects. Moreover, the combination of pro-inflammatory interleukin-21 (IL-21) and B cell receptor (BCR) stimulation enables B cells to produce and secrete granzyme B (GrB), which plays a critical role in early anti-viral immune responses, in the regulation of autoimmune mechanisms and in cancer immunosurveillance. Our data demonstrate that in the elderly, naïve/memory B cell populations present a different expression of the studied receptors that could be discussed in terms of “inflamm-aging”. In particular IgG+IgD−CD27− DN B cells show a tissue trafficking phenotype and they can be stimulated to produce GrB.
| Data di pubblicazione: | 2014 |
| Titolo: | Trafficking phenotype and production of granzyme B by double negative B cells (IgG(+)IgD(-)CD27(-)) in the elderly. |
| Autori: | |
| Citazione: | Bulati, M., Buffa, S., Martorana, A., Candore, G., Lio, D., Caruso, C., et al. (2014). Trafficking phenotype and production of granzyme B by double negative B cells (IgG(+)IgD(-)CD27(-)) in the elderly. EXPERIMENTAL GERONTOLOGY, 14, 123-129. |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.exger.2013.12.011 |
| Abstract: | The impairment of humoral immune response in elderly humans has been extensively demonstrated. We have reported the increase of memory B cells (IgG+IgD−CD27−, double negative, DN) population in the elderly, in which there is also a typical inflammatory micro-environment. In order to evaluate whether this pro-inflammatory status could influence the trafficking phenotype of naïve/memory B cells, we have assessed the expression of CCR7, CCR6, CXCR3, CXCR4, CXCR5 and CD62L on naïve/memory B cell subpopulations in young and elderly subjects. Moreover, the combination of pro-inflammatory interleukin-21 (IL-21) and B cell receptor (BCR) stimulation enables B cells to produce and secrete granzyme B (GrB), which plays a critical role in early anti-viral immune responses, in the regulation of autoimmune mechanisms and in cancer immunosurveillance. Our data demonstrate that in the elderly, naïve/memory B cell populations present a different expression of the studied receptors that could be discussed in terms of “inflamm-aging”. In particular IgG+IgD−CD27− DN B cells show a tissue trafficking phenotype and they can be stimulated to produce GrB. |
| Settore Scientifico Disciplinare: | Settore MED/04 - Patologia Generale Settore MED/05 - Patologia Clinica |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| BULATI 2014 TRAFFICKING.pdf | N/A | Open Access Visualizza/Apri |
http://hdl.handle.net/10447/99754
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