A new polycylic compound was synthesized and evaluated for its antiproliferative activity against the NCI panel of human tumoral cell lines showing IC50 values in the range 0.47-5.43 µM. The compound induced a decrease of the level of cyclin B1, whereas increased the level of the inhibitor p21 WAF1
Maggio, B., Raimondi, M.V., Cascioferro, S., Scherrmann, M.C., Prosa, N., Lauricella, M., et al. (2014). Synthesis and antiproliferative activity of a natural like glucosyl polycyclic compound. In Atti del XXV Congresso Nazionale della Società Chimica Italiana (pp.379-379).
Synthesis and antiproliferative activity of a natural like glucosyl polycyclic compound
MAGGIO, Benedetta;RAIMONDI, Maria Valeria;CASCIOFERRO, Stella Maria;LAURICELLA, Marianna;CARLISI, Daniela;DAIDONE, Giuseppe
2014-01-01
Abstract
A new polycylic compound was synthesized and evaluated for its antiproliferative activity against the NCI panel of human tumoral cell lines showing IC50 values in the range 0.47-5.43 µM. The compound induced a decrease of the level of cyclin B1, whereas increased the level of the inhibitor p21 WAF1
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