Several new 2-cinnamamido, 2-(3-phenylpropiolamido) and 2-(3-phenylpropanamido)benzamides were synthesized by stirring in pyridine the opportune acid chlorides with the appropriate anthranilamide derivatives. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).

Raffa, D., Maggio, B., Plescia, F., Cascioferro, S., Raimondi, M.V., Cusimano, M.G., et al. (2013). 2-cinnamamido, 2-(3-phenylpropiolamido) and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity and mechanism of action. In Book of Abstracts of 21th National Meeting on Medicinal Chemistry (pp.111-111).

2-cinnamamido, 2-(3-phenylpropiolamido) and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity and mechanism of action

RAFFA, Demetrio;MAGGIO, Benedetta;PLESCIA, Fabiana;CASCIOFERRO, Stella Maria;RAIMONDI, Maria Valeria;CUSIMANO, Maria Grazia;SCHILLACI, Domenico;DAIDONE, Giuseppe;
2013-01-01

Abstract

Several new 2-cinnamamido, 2-(3-phenylpropiolamido) and 2-(3-phenylpropanamido)benzamides were synthesized by stirring in pyridine the opportune acid chlorides with the appropriate anthranilamide derivatives. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).
Settore CHIM/08 - Chimica Farmaceutica
Settore BIO/19 - Microbiologia Generale
lug-2012
21th National Meeting on Medicinal Chemistry
Palermo
17-20 luglio 2012
2013
1
Raffa, D., Maggio, B., Plescia, F., Cascioferro, S., Raimondi, M.V., Cusimano, M.G., et al. (2013). 2-cinnamamido, 2-(3-phenylpropiolamido) and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity and mechanism of action. In Book of Abstracts of 21th National Meeting on Medicinal Chemistry (pp.111-111).
Proceedings (atti dei congressi)
Raffa, D; Maggio, B; Plescia, F; Cascioferro, S; Raimondi, MV; Cusimano, MG; Schillaci, D; Daidone, G; Amico, G; Carollo, C; Conaldi P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/79425
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