Pulsed electron-beam irradiation of poly(N-vinyl pyrrolidone) (PVP) aqueous solutions, at relatively low energy per pulse and doses within the sterilization dose range, has led to a variety of PVP nanogels of controlled size, that can be simultaneously grafted with a variety of functional monomers. Their crosslinked cores and multibranched arms with pendant carboxyl or amino groups ensure colloidal stability in a wide range of pHs and amenability to conjugation with fluorescent probes, ligands of specific cell receptors, such as short peptides, antibodies or oligonucleotides, and different type of therapeutics. Nanogels were proved to be not cytotoxic or genotoxic at the cellular level. Indeed, they showed good affinity for cells, as they rapidly and quantitatively bypass the cellular compartments, to accumulate in specific cell portions, then being completely released from the cells within 24 h
DISPENZA, C., GRIMALDI, N., SABATINO, M.A., ADAMO, G., RIGOGLIUSO, S., & GHERSI, G. (2013). Large-scale manufacturing of radiation sculptured therapeutic nanogels. In Nanotech 2013 Vol. 3 (pp. 202-205).
Data di pubblicazione: | 2013 | |
Titolo: | Large-scale manufacturing of radiation sculptured therapeutic nanogels | |
Autori: | ||
Citazione: | DISPENZA, C., GRIMALDI, N., SABATINO, M.A., ADAMO, G., RIGOGLIUSO, S., & GHERSI, G. (2013). Large-scale manufacturing of radiation sculptured therapeutic nanogels. In Nanotech 2013 Vol. 3 (pp. 202-205). | |
Abstract: | Pulsed electron-beam irradiation of poly(N-vinyl pyrrolidone) (PVP) aqueous solutions, at relatively low energy per pulse and doses within the sterilization dose range, has led to a variety of PVP nanogels of controlled size, that can be simultaneously grafted with a variety of functional monomers. Their crosslinked cores and multibranched arms with pendant carboxyl or amino groups ensure colloidal stability in a wide range of pHs and amenability to conjugation with fluorescent probes, ligands of specific cell receptors, such as short peptides, antibodies or oligonucleotides, and different type of therapeutics. Nanogels were proved to be not cytotoxic or genotoxic at the cellular level. Indeed, they showed good affinity for cells, as they rapidly and quantitatively bypass the cellular compartments, to accumulate in specific cell portions, then being completely released from the cells within 24 h | |
ISBN: | 978-1-4822-0586-2 | |
Settore Scientifico Disciplinare: | Settore CHIM/07 - Fondamenti Chimici Delle Tecnologie | |
Appare nelle tipologie: | 2.07 Contributo in atti di convegno pubblicato in volume |
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