Background andaims: Orai mucositis (OM) is one of thè most frequent and potentially severe acute side effect of non-surgical cancer therapy which often leads to significant morbidity, mortality and decreased quality of life. Today a standard and universally accepted management strategy to prevent and treat it does not exist. Given thè key role played by connective damage in its pathogenesis, thè use of a compound which promotes thè extracellular matrix regeneration couìd be a valid therapeutic strategy. In this regard, thè use of hyaluronic acid, that plays an important role in orai lissue healing by means of several mechanisms, has been showed to provide good results in managing OM. The aim of this open clinical trial is to assess thè effects of a spray compound containing a pool of collagen precursor synthetic aminoacids (1-proline, 1-SeucÌne. 1- lysine and giycine) combined with sodium hyaluronate in thè treatment of OM. Materials and methods: Fifty-four patients with OM were consecutively and unseiec- tively recruited. The treatment efficacy was evaluated on (i) pain score, (ii) clinicaì resolution index (CRI) and (iii) WHO Mucositis scale recorded at times TO (baseline). T01 (2 h), TI (24 h), T2 (72 h), T3 (7 days) and T4 (14 days). Results: The application of thè spray showed a significant reduction in paìn after only 2 h compared with baseline measurements (P < 0.0001). A progressive reduction of pain through thè 2 weeks was also noted (P < 0.0001). Patient ìesions treated with thè spray also significantly improved after 72 h of treatment both in terms of CRI (P = 0.0186) and as WHO Mucositis score (P < 0.0001). Conclusions and relevance: Although further studies are recommended. our fìndings confimi that spray formulation may offer rapid and effective paìn management aiding a fast mucosal wound healing with consequent improvement of thè ability to eat anc drink which usually compromises patients suffering from OM.
Compilato, D., Colella, G., Fulfaro, F., Vicidomini, A., & Campisi, G. (2012). Effective use of a sodium-hyaluronate spray formulation in oral mucositis. In Abstracts of the 11th Biennial Congress of the European Association of Oral Medicine, 13 to 15 September 2012, Athens, Greece (pp.25-25). Wiley-Blackwell.
|Autori:||Compilato, D.; Colella, G.; Fulfaro, F.; Vicidomini, A.; Campisi, G.|
|Titolo:||Effective use of a sodium-hyaluronate spray formulation in oral mucositis|
|Settore Scientifico Disciplinare:||Settore MED/28 - Malattie Odontostomatologiche|
|Nome del convegno:||11th Biennal Congress of European Association of Oral Medicine (EAOM)|
|Luogo del convegno:||Atene|
|Anno del convegno:||13-15 Settembre 2012|
|Data di pubblicazione:||2012|
|Numero di pagine:||1|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/j.1601-0825.2012.12005_2.x|
|Citazione:||Compilato, D., Colella, G., Fulfaro, F., Vicidomini, A., & Campisi, G. (2012). Effective use of a sodium-hyaluronate spray formulation in oral mucositis. In Abstracts of the 11th Biennial Congress of the European Association of Oral Medicine, 13 to 15 September 2012, Athens, Greece (pp.25-25). Wiley-Blackwell.|
|Tipologia:||0 - Proceedings (TIPOLOGIA NON ATTIVA)|
|Appare nelle tipologie:||0 - Proceedings (TIPOLOGIA NON ATTIVA)|