Follistatin as potential therapeutic target in prostate cancer

Sepporta, M; Tumminello, FM; Flandina, C; Crescimanno, M; Giammanco, M; La Guardia, M; Di Majo, D; Leto, G

doi:DOI 10.1007/s11523-013-0268-7

Follistatin is a single-chain glycosylated protein whose primary function consists in binding and neutralizing some members of the transforming growth factor-β superfamily such as activin and bone morphogenic proteins. Emerging evidence indicates that this molecule may also play a role in the malignant progression of several human tumors including prostate cancer. In particular, recent findings suggest that, in this tumor, follistatin may also contribute to the formation of bone metastasis through multiple mechanisms, some of which are not related to its specific activin or bone morphogenic proteins’ inhibitory activity. This review provides insight into the most recent advances in understanding the role of follistatin in the prostate cancer progression and discusses the clinical and therapeutic implications related to these findings.

Sepporta, M., Tumminello, F., Flandina, C., Crescimanno, M., Giammanco, M., LA GUARDIA, M., et al. (2013). Follistatin as potential therapeutic target in prostate cancer. TARGETED ONCOLOGY, 8(00) [DOI 10.1007/s11523-013-0268-7].

Data di pubblicazione:	2013
Titolo:	Follistatin as potential therapeutic target in prostate cancer
Autori:	Sepporta, MV TUMMINELLO, Francesca Maria FLANDINA, Carla CRESCIMANNO, Marilena GIAMMANCO, Marco LA GUARDIA, Maurizio DI MAJO, Danila LETO, Gaetano mostra contributor esterni nascondi contributor esterni
Citazione:	Sepporta, M., Tumminello, F., Flandina, C., Crescimanno, M., Giammanco, M., LA GUARDIA, M., et al. (2013). Follistatin as potential therapeutic target in prostate cancer. TARGETED ONCOLOGY, 8(00) [DOI 10.1007/s11523-013-0268-7].
Rivista:	TARGETED ONCOLOGY
Digital Object Identifier (DOI):	http://dx.doi.org/DOI 10.1007/s11523-013-0268-7
Appare nelle tipologie:	1.01 Articolo in rivista

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File	Descrizione	Tipologia	Licenza
10.1007_s11523-013-0268-7.pdf	review	N/A		Open Access Visualizza/Apri
FLS rev Targ Oncol 2013.pdf		N/A		Open Access Visualizza/Apri

Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/10447/70447

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