A rapid and cost-effective method combining Material Extrusion (MEX) and salt leaching was developed to produce porous hollow devices with tunable porosity, for reservoir-type controlled release. High-porogen-content blends (PA6/NaCl 30/70 wt%) with different salt sizes enabled predictable pore morphology. The printed devices exhibited complete leaching, high porosity, and sufficient mechanical properties. Methylene blue release tests confirmed interconnected pores and tunable kinetics based on porogen size. CFD tests confirm that it can be used in contact with blood. The process is versatile for controlled release applications and allows customization of complex geometries.
Balsamo, M., Mistretta, M.C., Pasta, S., Scaffaro, R. (2025). MELT-WET PROCESSING FOR RESERVOIR-TYPE CONTROLLED RELEASE. In Convegno Nazionale di Bioingegneria 2025. Patron Editore S.r.l..
MELT-WET PROCESSING FOR RESERVOIR-TYPE CONTROLLED RELEASE
Balsamo M.;Mistretta M. C.;Pasta S.;Scaffaro R.
2025-01-01
Abstract
A rapid and cost-effective method combining Material Extrusion (MEX) and salt leaching was developed to produce porous hollow devices with tunable porosity, for reservoir-type controlled release. High-porogen-content blends (PA6/NaCl 30/70 wt%) with different salt sizes enabled predictable pore morphology. The printed devices exhibited complete leaching, high porosity, and sufficient mechanical properties. Methylene blue release tests confirmed interconnected pores and tunable kinetics based on porogen size. CFD tests confirm that it can be used in contact with blood. The process is versatile for controlled release applications and allows customization of complex geometries.
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