FLUID-STRUCTURE INTERACTION SIMULATION OF TRANSCATHETER AORTIC VALVE IMPLANTATION USING SMOOTHED PARTICLE HYDRODYNAMICS

This study explores the structural and hemodynamic response in patients who underwent transcatheter aortic valve implantation (TAVI) using a fluid-structure interaction (FSI) approach based on meshless smoothed particle hydrodynamics (SPH). Unlike previous studies that assumed rigid components, this study developed a SPH model capable of accounting for two-way fluid-solid interaction (FSI) for all parts (ie, patient anatomy and device components). The model integrated the Sapien 3 (S3) TAVI device (Edwards Lifesciences, Irvine, CA) into personalized anatomical frameworks and employed rigorous verification and validation activities. Patient-specific pressure and flow boundary conditions were used for simulations. Results from 10 patient-specific simulations showed that the SPH approach realistically simulated the dynamic response of the S3 device during the cardiac cycle, providing insights into device performance, and aortic root deformation. In conclusion, this study presents a comprehensive computational framework for TAVI, leveraging SPH for accurate fluid-solid interaction analysis, which could advance post-TAVI hemodynamic understanding and facilitate the development of an in-silico platform for biomedical device testing.