The submerged Sill in the Messina Strait, which is located at a depth of -81 m m.s.l., represents the only possibile connection between Calabria and Sicily during the last lowstand, when the sea level was at about -126 m m.s.l.. This multidisciplinary research aim at documenting times and modes the bridge between Calabria and Sicily was emerged, during the last 40 ka BP. The analysis carried out on morphobathymetric, lithological and relative sea level change (both isostatic and tectonic) data allow to hypothesize the continental bridge emerged at least between 21.5 ka and 20 ka cal BP. Moreover, considering erosion processes due to very strong marine currents, it could be emerged for a longer time span. This hypothesis is supported by anthropological and mammalofauna data, together with 14C dating on Equus hydruntinus from San Teodoro Cave.