Aggressive B-cell lymphomas share high proliferative and invasive attitudes and dismal prognosis despite heterogeneous biological features. In the interchained sequence of events leading to cancer progression, neoplastic clone-intrinsic molecular events play a major role. Nevertheless, microenvironment-related cues have progressively come into focus as true determinants for this process. The cancer-associated microenvironment is a complex network of nonneoplastic immune and stromal cells embedded in extracellular components, giving rise to a multifarious crosstalk with neoplastic cells towards the induction of a supportive milieu. The immunological and stromal microenvironments have been classically regarded as essential partners of indolent lymphomas, while considered mainly negligible in the setting of aggressive B-cell lymphomas that, by their nature, are less reliant on external stimuli. By this paper we try to delineate the cardinal microenvironment-centred dynamics exerting an influence over lymphoid clone progression in aggressive B-cell lymphomas.
|Data di pubblicazione:||19-feb-2012|
|Titolo:||Microenvironment-centred dynamics in aggressive B-cell lymphomas.|
|Autori:||Cacciatore, M; Guarnotta, C; Calvaruso, M; Sangaletti, S; Florena, AM; Franco, V; Colombo, MP; Tripodo, C|
|Tipologia:||Articolo su rivista|
|Citazione:||Cacciatore, M., Guarnotta, C., Calvaruso, M., Sangaletti, S., Florena, A.M., Franco, V., et al. (2012). Microenvironment-centred dynamics in aggressive B-cell lymphomas. ADVANCES IN HEMATOLOGY, 2012.|
|Tipo:||Articolo in rivista|
|Appare nelle tipologie:||01 - Articolo su rivista|