Aggressive B-cell lymphomas share high proliferative and invasive attitudes and dismal prognosis despite heterogeneous biological features. In the interchained sequence of events leading to cancer progression, neoplastic clone-intrinsic molecular events play a major role. Nevertheless, microenvironment-related cues have progressively come into focus as true determinants for this process. The cancer-associated microenvironment is a complex network of nonneoplastic immune and stromal cells embedded in extracellular components, giving rise to a multifarious crosstalk with neoplastic cells towards the induction of a supportive milieu. The immunological and stromal microenvironments have been classically regarded as essential partners of indolent lymphomas, while considered mainly negligible in the setting of aggressive B-cell lymphomas that, by their nature, are less reliant on external stimuli. By this paper we try to delineate the cardinal microenvironment-centred dynamics exerting an influence over lymphoid clone progression in aggressive B-cell lymphomas.

Cacciatore, M., Guarnotta, C., Calvaruso, M., Sangaletti, S., Florena, A.M., Franco, V., et al. (2012). Microenvironment-centred dynamics in aggressive B-cell lymphomas. ADVANCES IN HEMATOLOGY, 2012.

Microenvironment-centred dynamics in aggressive B-cell lymphomas.

CACCIATORE, Matilde;GUARNOTTA, Carla;CALVARUSO, Marco;FLORENA, Ada Maria;FRANCO, Vito;TRIPODO, Claudio
2012-01-01

Abstract

Aggressive B-cell lymphomas share high proliferative and invasive attitudes and dismal prognosis despite heterogeneous biological features. In the interchained sequence of events leading to cancer progression, neoplastic clone-intrinsic molecular events play a major role. Nevertheless, microenvironment-related cues have progressively come into focus as true determinants for this process. The cancer-associated microenvironment is a complex network of nonneoplastic immune and stromal cells embedded in extracellular components, giving rise to a multifarious crosstalk with neoplastic cells towards the induction of a supportive milieu. The immunological and stromal microenvironments have been classically regarded as essential partners of indolent lymphomas, while considered mainly negligible in the setting of aggressive B-cell lymphomas that, by their nature, are less reliant on external stimuli. By this paper we try to delineate the cardinal microenvironment-centred dynamics exerting an influence over lymphoid clone progression in aggressive B-cell lymphomas.
Cacciatore, M., Guarnotta, C., Calvaruso, M., Sangaletti, S., Florena, A.M., Franco, V., et al. (2012). Microenvironment-centred dynamics in aggressive B-cell lymphomas. ADVANCES IN HEMATOLOGY, 2012.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/64084
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