Ventriculitis and nosocomial meningitis caused by carbapenem-resistant Gram-negative and vancomycin-resistant Gram-positive bacteria represent a growing treatment challenge. A case of ventriculitis and bacteremia caused by carbapenem-resistant, KPC-producing Klebsiella pneumoniae and vancomycin-resistant Enterococcus faecium in a young woman with acute leukemia who was successfully treated with meropenem/vaborbactam (MVB), rifampicin, and linezolid is described in this paper. This case report emphasizes the importance of a multidisciplinary strategy, including infectious focus control, for the treatment of device-associated central nervous system (CNS) infections from multidrug-resistant bacteria. Considering the novel resistance patterns, more research on drug penetration into the central nervous system, as well as on the necessity of association therapies, is needed.

Rubino, R., Trizzino, M., Pipitò, L., Sucato, G., Santoro, M., Maugeri, R., et al. (2024). A Difficult Case of Ventriculitis in a 40-Year-Old Woman with Acute Myeloid Leukemia. ANTIBIOTICS, 13(5), 1-9 [10.3390/antibiotics13050432].

A Difficult Case of Ventriculitis in a 40-Year-Old Woman with Acute Myeloid Leukemia

Rubino, Raffaella
Primo
;
Trizzino, Marcello
Secondo
;
Santoro, Marco;Maugeri, Rosario;Iacopino, Domenico Gerardo;Giammanco, Giovanni Maurizio;Siragusa, Sergio
Penultimo
;
Cascio, Antonio
Ultimo
2024-05-10

Abstract

Ventriculitis and nosocomial meningitis caused by carbapenem-resistant Gram-negative and vancomycin-resistant Gram-positive bacteria represent a growing treatment challenge. A case of ventriculitis and bacteremia caused by carbapenem-resistant, KPC-producing Klebsiella pneumoniae and vancomycin-resistant Enterococcus faecium in a young woman with acute leukemia who was successfully treated with meropenem/vaborbactam (MVB), rifampicin, and linezolid is described in this paper. This case report emphasizes the importance of a multidisciplinary strategy, including infectious focus control, for the treatment of device-associated central nervous system (CNS) infections from multidrug-resistant bacteria. Considering the novel resistance patterns, more research on drug penetration into the central nervous system, as well as on the necessity of association therapies, is needed.
10-mag-2024
Settore MED/07 - Microbiologia E Microbiologia Clinica
Settore MED/09 - Medicina Interna
Settore MED/15 - Malattie Del Sangue
Settore MED/17 - Malattie Infettive
Settore MED/27 - Neurochirurgia
Rubino, R., Trizzino, M., Pipitò, L., Sucato, G., Santoro, M., Maugeri, R., et al. (2024). A Difficult Case of Ventriculitis in a 40-Year-Old Woman with Acute Myeloid Leukemia. ANTIBIOTICS, 13(5), 1-9 [10.3390/antibiotics13050432].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/639899
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