The current carbapenem-resistant gram-negative bacteria (CR-GN) treatment guidelines lack strong evidence about cefiderocol (CFD) efficacy against CR-GN, especially CRAB. The study’s purpose is to evaluate the effectiveness of CFD in a real-life setting. We made a single-center retrospective study of 41 patients who received CFD in our hospital for several CR-GN infections. Bloodstream infections (BSI) affected 43.9% (18/41) of patients, while CRAB affected 75.6% (31/41) of isolated CR-GN patients. Thirty-days (30-D) all-causes mortality affected 36.6% (15/41) of patients, while end-of-treatment (EOT) clinical cure affected 56.1% (23/41). Finally, microbiological eradication at EOT affected 56.1% (23/41) of patients. Univariate and multivariate analysis showed that septic shock is an independent factor associated with mortality. Subgroup analyses showed no difference in CFD effectiveness between monotherapy and combination therapy.

Palermo G., Medaglia A.A., Pipito L., Rubino R., Costantini M., Accomando S., et al. (2023). Cefiderocol Efficacy in a Real-Life Setting: Single-Centre Retrospective Study. ANTIBIOTICS, 12(4) [10.3390/antibiotics12040746].

Cefiderocol Efficacy in a Real-Life Setting: Single-Centre Retrospective Study

Medaglia A. A.;Rubino R.;Accomando S.;Giammanco G. M.;Cascio A.
Ultimo
2023-01-01

Abstract

The current carbapenem-resistant gram-negative bacteria (CR-GN) treatment guidelines lack strong evidence about cefiderocol (CFD) efficacy against CR-GN, especially CRAB. The study’s purpose is to evaluate the effectiveness of CFD in a real-life setting. We made a single-center retrospective study of 41 patients who received CFD in our hospital for several CR-GN infections. Bloodstream infections (BSI) affected 43.9% (18/41) of patients, while CRAB affected 75.6% (31/41) of isolated CR-GN patients. Thirty-days (30-D) all-causes mortality affected 36.6% (15/41) of patients, while end-of-treatment (EOT) clinical cure affected 56.1% (23/41). Finally, microbiological eradication at EOT affected 56.1% (23/41) of patients. Univariate and multivariate analysis showed that septic shock is an independent factor associated with mortality. Subgroup analyses showed no difference in CFD effectiveness between monotherapy and combination therapy.
2023
Palermo G., Medaglia A.A., Pipito L., Rubino R., Costantini M., Accomando S., et al. (2023). Cefiderocol Efficacy in a Real-Life Setting: Single-Centre Retrospective Study. ANTIBIOTICS, 12(4) [10.3390/antibiotics12040746].
File in questo prodotto:
File Dimensione Formato  
Cefiderocol Efficacy in a Real-Life Setting Single-Centre Retrospective Study -antibiotics-12-00746.pdf

accesso aperto

Tipologia: Versione Editoriale
Dimensione 1.08 MB
Formato Adobe PDF
1.08 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/620221
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 4
social impact