Wastewater-based epidemiology is a well-established tool for detecting and monitoring the spread of enteric pathogens and the use of illegal drugs in communities in real time. Since only a few studies in Italy have investigated the correlation between SARS-CoV-2 in wastewater and the prevalence of COVID-19 cases from clinical testing, we conducted a one-year wastewater surveillance study in Sicily to correlate the load of SARS-CoV-2 RNA in wastewater and the reported cumulative prevalence of COVID-19 in 14 cities from October 2021 to September 2022. Furthermore, we investigated the role of SARS-CoV-2 variants and subvariants in the increase in the number of SARS CoV-2 infections. Our findings showed a significant correlation between SARS-CoV-2 RNA load in wastewater and the number of active cases reported by syndromic surveillance in the population. Moreover, the correlation between SARS-CoV-2 in wastewater and the active cases remained high when a lag of 7 or 14 days was considered. Finally, we attributed the epidemic waves observed to the rapid emergence of the Omicron variant and the BA.4 and BA.5 subvariants. We confirmed the effectiveness of wastewater monitoring as a powerful epidemiological proxy for viral variant spread and an efficient complementary method for surveillance.

Maida, C.M., Tramuto, F., Giammanco, G.M., Palermo, R., Priano, W., De Grazia, S., et al. (2023). Wastewater-Based Epidemiology as a Tool to Detect SARS-CoV-2 Circulation at the Community Level: Findings from a One-Year Wastewater Investigation Conducted in Sicily, Italy. PATHOGENS, 12(6), 748 [10.3390/pathogens12060748].

Wastewater-Based Epidemiology as a Tool to Detect SARS-CoV-2 Circulation at the Community Level: Findings from a One-Year Wastewater Investigation Conducted in Sicily, Italy

Maida, Carmelo Massimo
Primo
Conceptualization
;
Tramuto, Fabio
Secondo
Writing – Review & Editing
;
Giammanco, Giovanni Maurizio
Writing – Review & Editing
;
Palermo, Roberta
Formal Analysis
;
Priano, Walter
Formal Analysis
;
De Grazia, Simona
Writing – Review & Editing
;
Purpari, Giuseppa
Writing – Review & Editing
;
Graziano, Giorgio
Writing – Review & Editing
;
Immordino, Palmira
Writing – Review & Editing
;
Vitale, Francesco
Writing – Review & Editing
;
Mazzucco, Walter
Ultimo
Writing – Original Draft Preparation
2023-05-01

Abstract

Wastewater-based epidemiology is a well-established tool for detecting and monitoring the spread of enteric pathogens and the use of illegal drugs in communities in real time. Since only a few studies in Italy have investigated the correlation between SARS-CoV-2 in wastewater and the prevalence of COVID-19 cases from clinical testing, we conducted a one-year wastewater surveillance study in Sicily to correlate the load of SARS-CoV-2 RNA in wastewater and the reported cumulative prevalence of COVID-19 in 14 cities from October 2021 to September 2022. Furthermore, we investigated the role of SARS-CoV-2 variants and subvariants in the increase in the number of SARS CoV-2 infections. Our findings showed a significant correlation between SARS-CoV-2 RNA load in wastewater and the number of active cases reported by syndromic surveillance in the population. Moreover, the correlation between SARS-CoV-2 in wastewater and the active cases remained high when a lag of 7 or 14 days was considered. Finally, we attributed the epidemic waves observed to the rapid emergence of the Omicron variant and the BA.4 and BA.5 subvariants. We confirmed the effectiveness of wastewater monitoring as a powerful epidemiological proxy for viral variant spread and an efficient complementary method for surveillance.
mag-2023
Settore MED/42 - Igiene Generale E Applicata
Settore MED/07 - Microbiologia E Microbiologia Clinica
Maida, C.M., Tramuto, F., Giammanco, G.M., Palermo, R., Priano, W., De Grazia, S., et al. (2023). Wastewater-Based Epidemiology as a Tool to Detect SARS-CoV-2 Circulation at the Community Level: Findings from a One-Year Wastewater Investigation Conducted in Sicily, Italy. PATHOGENS, 12(6), 748 [10.3390/pathogens12060748].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/590771
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