The concept of protein kinase inhibition starts from the groundbreaking research on the role of these proteins in the regulation of fundamental processes, including proliferation, cell cycle, apoptosis, metabolism, and inflammation. Kinase genetic mutations, as well as overexpression and dysregulation, can contribute to the development of several diseases, including neoplasms, leading to relapses and resistance to standard drug chemotherapy [1-3].
Pecoraro C., Carbone D., Cascioferro S.M., Parrino B., Diana P. (2023). Multi or Single-Kinase Inhibitors to Counteract Drug Resistance in Cancer: What is New?. CURRENT MEDICINAL CHEMISTRY, 30(7), 776-782 [10.2174/0929867329666220729152741].
Multi or Single-Kinase Inhibitors to Counteract Drug Resistance in Cancer: What is New?
Pecoraro C.Primo
;Carbone D.Secondo
;Cascioferro S. M.;Parrino B.;Diana P.
2023-02-01
Abstract
The concept of protein kinase inhibition starts from the groundbreaking research on the role of these proteins in the regulation of fundamental processes, including proliferation, cell cycle, apoptosis, metabolism, and inflammation. Kinase genetic mutations, as well as overexpression and dysregulation, can contribute to the development of several diseases, including neoplasms, leading to relapses and resistance to standard drug chemotherapy [1-3].
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