The development of biomedical systems with antimicrobial and antibiofilm properties is a difficult medical task for preventing bacterial adhesion and growth on implanted devices. In this work, a fibrillar scaffold was produced by electrospinning a polymeric organic dispersion of polylactic acid (PLA) and poly( , -(N-(3,4-dihydroxyphenethyl)-L-aspartamide-co- , -N-(2-hydroxyethyl)-Laspartamide) (PDAEA). The pendant catechol groups of PDAEA were used to reduce silver ions in situ and produce silver nanoparticles onto the surface of the electrospun fibers through a simple and reproducible procedure. The morphological and physicochemical characterization of the obtained scaffolds were studied and compared with virgin PLA electrospun sample. Antibiofilm properties against Pseudomonas aeruginosa, used as a biofilm-forming pathogen model, were also studied on planar and tubular scaffolds. These last were fabricated as a proof of concept to demonstrate the possibility to obtain antimicrobial devices with different shape and dimension potentially useful for different biomedical applications. The results suggest a promising approach for the development of antimicrobial and antibiofilm scaffolds.

Giovanna Pitarresi, G.B. (2022). Developing Antibiofilm Fibrillar Scaffold with Intrinsic Capacity to Produce Silver Nanoparticles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(23) [10.3390/ijms232315378].

Developing Antibiofilm Fibrillar Scaffold with Intrinsic Capacity to Produce Silver Nanoparticles

Giovanna Pitarresi;Giuseppe Barberi;Fabio Salvatore Palumbo;Domenico Schillaci;Calogero Fiorica
;
Valentina Catania
;
Serena Indelicato;David Bongiorno;Giuseppina Biscari;Gaetano Giammona
2022-12-06

Abstract

The development of biomedical systems with antimicrobial and antibiofilm properties is a difficult medical task for preventing bacterial adhesion and growth on implanted devices. In this work, a fibrillar scaffold was produced by electrospinning a polymeric organic dispersion of polylactic acid (PLA) and poly( , -(N-(3,4-dihydroxyphenethyl)-L-aspartamide-co- , -N-(2-hydroxyethyl)-Laspartamide) (PDAEA). The pendant catechol groups of PDAEA were used to reduce silver ions in situ and produce silver nanoparticles onto the surface of the electrospun fibers through a simple and reproducible procedure. The morphological and physicochemical characterization of the obtained scaffolds were studied and compared with virgin PLA electrospun sample. Antibiofilm properties against Pseudomonas aeruginosa, used as a biofilm-forming pathogen model, were also studied on planar and tubular scaffolds. These last were fabricated as a proof of concept to demonstrate the possibility to obtain antimicrobial devices with different shape and dimension potentially useful for different biomedical applications. The results suggest a promising approach for the development of antimicrobial and antibiofilm scaffolds.
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
https://www.mdpi.com/1422-0067/23/23/15378
Giovanna Pitarresi, G.B. (2022). Developing Antibiofilm Fibrillar Scaffold with Intrinsic Capacity to Produce Silver Nanoparticles. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(23) [10.3390/ijms232315378].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/578233
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