For accurately measuring kLa in bioreactors the dynamic pressure method (DPM) was introduced by Linek et al. (1993). In this work a simplified version of the same method is discussed. With respect to the original DPM, the simplified version greatly simplifies data treatment. In fact final constant slope observable in the usual semi-log diagram of residual driving force versus time may be simply corrected to obtain the real kLa value with negligible inaccuracy. Experimental data obtained on a lab-size stirred tank reactor confirm all model predictions, including the feature that the adoption of large pressure changes may lead to a better accuracy.

SCARGIALI, F., BUSCIGLIO, A., GRISAFI, F., BRUCATO, A. (2010). kLa MEASUREMENT IN BIOREACTORS. In CHEMICAL ENGINEERING TRANSACTIONS, online Volume 20, 2010 (pp.229-234). Milano : AIDIC - Milano [10.3303/CET1020039].

kLa MEASUREMENT IN BIOREACTORS

SCARGIALI, Francesca;GRISAFI, Franco;BRUCATO, Alberto
2010-01-01

Abstract

For accurately measuring kLa in bioreactors the dynamic pressure method (DPM) was introduced by Linek et al. (1993). In this work a simplified version of the same method is discussed. With respect to the original DPM, the simplified version greatly simplifies data treatment. In fact final constant slope observable in the usual semi-log diagram of residual driving force versus time may be simply corrected to obtain the real kLa value with negligible inaccuracy. Experimental data obtained on a lab-size stirred tank reactor confirm all model predictions, including the feature that the adoption of large pressure changes may lead to a better accuracy.
Settore ING-IND/25 - Impianti Chimici
2010
4th International Conference on Industrial Biotechnology
Rome
8-11 June
2010
6
Online
SCARGIALI, F., BUSCIGLIO, A., GRISAFI, F., BRUCATO, A. (2010). kLa MEASUREMENT IN BIOREACTORS. In CHEMICAL ENGINEERING TRANSACTIONS, online Volume 20, 2010 (pp.229-234). Milano : AIDIC - Milano [10.3303/CET1020039].
Proceedings (atti dei congressi)
SCARGIALI, F; BUSCIGLIO, A; GRISAFI, F; BRUCATO, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/57726
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