The present study was conducted to investigate serotype distribution, antimicrobial resistance patterns, carriage of class 1 integron, and clonality of Salmonella strains isolated from patients aged 0-12 years in Tehran, Iran, during 2007-2008. A total of 139 Salmonella isolates were studied. Salmonella serotypes Enteritidis, Infantis, and Typhimurium included 84.9% of isolates, Enteritidis accounting for 41.7%. The most prevalent resistances were to doxycycline (64.7%), nalidixic acid (61.2%), tetracycline (51.8%), and streptomycin (42.8%). Fifty-three (38.1%) isolates contained class 1 integron. Eight different gene cassettes were identified, aadA1 being the most frequently encountered. Pulsed-field gel electrophoresis showed that integron-positive Salmonella strains belonging to serotypes Infantis, Enteritidis, and Typhimurium were attributed to two, three, and five different pulsotypes, respectively. The findings indicated that the distribution and drug resistance pattern of most prevalent Salmonella serotypes were broadly similar to that reported globally from human isolates. Presence of class 1 integrons was common among Salmonella serotypes in Tehran, Iran. Concurrent clonal expansion and horizontal transmission events seem to contribute to increase in drug resistance prevalence among Salmonella serotypes.

Ranjbar, R., Giammanco, G., Farshad, S., Owlia, P., Aleo, A., & Mammina, C. (2011). Serotypes, antibiotic resistance and class 1 integrons in Salmonella isolates from pediatric cases of enteritis in Tehran, Iran. FOODBORNE PATHOGENS AND DISEASE, 8(4), 547-553 [10.1089/fpd.2010.0736].

Serotypes, antibiotic resistance and class 1 integrons in Salmonella isolates from pediatric cases of enteritis in Tehran, Iran

GIAMMANCO, Giovanni;ALEO, Aurora;MAMMINA, Caterina
2011

Abstract

The present study was conducted to investigate serotype distribution, antimicrobial resistance patterns, carriage of class 1 integron, and clonality of Salmonella strains isolated from patients aged 0-12 years in Tehran, Iran, during 2007-2008. A total of 139 Salmonella isolates were studied. Salmonella serotypes Enteritidis, Infantis, and Typhimurium included 84.9% of isolates, Enteritidis accounting for 41.7%. The most prevalent resistances were to doxycycline (64.7%), nalidixic acid (61.2%), tetracycline (51.8%), and streptomycin (42.8%). Fifty-three (38.1%) isolates contained class 1 integron. Eight different gene cassettes were identified, aadA1 being the most frequently encountered. Pulsed-field gel electrophoresis showed that integron-positive Salmonella strains belonging to serotypes Infantis, Enteritidis, and Typhimurium were attributed to two, three, and five different pulsotypes, respectively. The findings indicated that the distribution and drug resistance pattern of most prevalent Salmonella serotypes were broadly similar to that reported globally from human isolates. Presence of class 1 integrons was common among Salmonella serotypes in Tehran, Iran. Concurrent clonal expansion and horizontal transmission events seem to contribute to increase in drug resistance prevalence among Salmonella serotypes.
Settore MED/07 - Microbiologia E Microbiologia Clinica
Settore MED/42 - Igiene Generale E Applicata
Ranjbar, R., Giammanco, G., Farshad, S., Owlia, P., Aleo, A., & Mammina, C. (2011). Serotypes, antibiotic resistance and class 1 integrons in Salmonella isolates from pediatric cases of enteritis in Tehran, Iran. FOODBORNE PATHOGENS AND DISEASE, 8(4), 547-553 [10.1089/fpd.2010.0736].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/54079
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