This chapter deals with 1,3-diheterocines, eight-membered heterocyclic systems with two heteroatoms, N, O and S, in a 1,3 relationship, exhibiting biological properties and exhaustively covers the literature from 2007 to the end of November 2019. The biological results of 1,3-diazocines, 1,3-oxazocines, 1,3-dioxocins and 1,3-thiazocines, that are the largest class of 1,3-diheterocines, were collected together with the few results available for 1,3-oxathiocin and 1,3-dithiocin derivatives at that time.
Barbara Parrino, Stella Cascioferro, Daniela Carbone, Camilla Pecoraro, Girolamo Cirrincione, Patrizia Diana (2022). Eight-membered heterocycles with two heteroatoms in a 1,3-relationship of interest in medicinal chemistry. In Advances in Heterocyclic Chemistry (pp. 1-57). Elsevier [10.1016/bs.aihch.2020.11.001].
Eight-membered heterocycles with two heteroatoms in a 1,3-relationship of interest in medicinal chemistry
Barbara ParrinoPrimo
;Stella CascioferroSecondo
;Daniela Carbone;Camilla Pecoraro;Patrizia Diana
Ultimo
2022-01-01
Abstract
This chapter deals with 1,3-diheterocines, eight-membered heterocyclic systems with two heteroatoms, N, O and S, in a 1,3 relationship, exhibiting biological properties and exhaustively covers the literature from 2007 to the end of November 2019. The biological results of 1,3-diazocines, 1,3-oxazocines, 1,3-dioxocins and 1,3-thiazocines, that are the largest class of 1,3-diheterocines, were collected together with the few results available for 1,3-oxathiocin and 1,3-dithiocin derivatives at that time.
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