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EnglishIn the last years, the development of nano-formulations for cancer treatment represents one of the major challenges of the scientific research. The prodrug strategy, that combines chemotherapeutic agents with nanocarriers such as halloysite nanotubes (HNTs), is a promising strategy both to improve the biological activity of the drug molecules and to reduce the side effects of drugs. Herein we report the synthesis and characterization of a HNTs prodrug based on 1,2,3-triazole units covalently linked to HNTs external surface, bearing different positively charged moieties, which could present interesting pharmacological activities.
Massaro, M., Colletti, C.G., Cavallaro, G., Lazzara, G., Meo, P.L., Riela, S., et al. (2022). 1,2,3-Oligotriazoles modified halloysite nanotubes as potential active biological species: synthesis and characterization. ARKIVOC, 2022(2), 1-9 [10.24820/ark.5550190.p011.685].
| Data di pubblicazione: | 2022 | |
| Titolo: | 1,2,3-Oligotriazoles modified halloysite nanotubes as potential active biological species: synthesis and characterization | |
| Autori: | MASSARO, Marina (Primo) Colletti, Carmelo Giuseppe (Secondo) NOTO, Renato (Ultimo) | |
| Citazione: | Massaro, M., Colletti, C.G., Cavallaro, G., Lazzara, G., Meo, P.L., Riela, S., et al. (2022). 1,2,3-Oligotriazoles modified halloysite nanotubes as potential active biological species: synthesis and characterization. ARKIVOC, 2022(2), 1-9 [10.24820/ark.5550190.p011.685]. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.24820/ark.5550190.p011.685 | |
| Abstract: | In the last years, the development of nano-formulations for cancer treatment represents one of the major challenges of the scientific research. The prodrug strategy, that combines chemotherapeutic agents with nanocarriers such as halloysite nanotubes (HNTs), is a promising strategy both to improve the biological activity of the drug molecules and to reduce the side effects of drugs. Herein we report the synthesis and characterization of a HNTs prodrug based on 1,2,3-triazole units covalently linked to HNTs external surface, bearing different positively charged moieties, which could present interesting pharmacological activities. | |
| URL dell'editore: | https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.p011.685 | |
| Settore Scientifico Disciplinare: | Settore CHIM/06 - Chimica Organica Settore CHIM/02 - Chimica Fisica | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 2022 ARKIVOC Allosite.pdf | Articolo principale | Versione Editoriale | Open Access Visualizza/Apri |
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