In the last years, the development of nano-formulations for cancer treatment represents one of the major challenges of the scientific research. The prodrug strategy, that combines chemotherapeutic agents with nanocarriers such as halloysite nanotubes (HNTs), is a promising strategy both to improve the biological activity of the drug molecules and to reduce the side effects of drugs. Herein we report the synthesis and characterization of a HNTs prodrug based on 1,2,3-triazole units covalently linked to HNTs external surface, bearing different positively charged moieties, which could present interesting pharmacological activities.

Massaro, M., Colletti, C.G., Cavallaro, G., Lazzara, G., Meo, P.L., Riela, S., et al. (2022). 1,2,3-Oligotriazoles modified halloysite nanotubes as potential active biological species: synthesis and characterization. ARKIVOC, 2022(2), 1-9 [10.24820/ark.5550190.p011.685].

1,2,3-Oligotriazoles modified halloysite nanotubes as potential active biological species: synthesis and characterization

Massaro, Marina
Primo
;
Colletti, Carmelo Giuseppe
Secondo
;
Cavallaro, Giuseppe;Lazzara, Giuseppe;Meo, Paolo Lo;Riela, Serena
Penultimo
;
Noto, Renato
Ultimo
2022-01-01

Abstract

In the last years, the development of nano-formulations for cancer treatment represents one of the major challenges of the scientific research. The prodrug strategy, that combines chemotherapeutic agents with nanocarriers such as halloysite nanotubes (HNTs), is a promising strategy both to improve the biological activity of the drug molecules and to reduce the side effects of drugs. Herein we report the synthesis and characterization of a HNTs prodrug based on 1,2,3-triazole units covalently linked to HNTs external surface, bearing different positively charged moieties, which could present interesting pharmacological activities.
2022
Settore CHIM/06 - Chimica Organica
Settore CHIM/02 - Chimica Fisica
Massaro, M., Colletti, C.G., Cavallaro, G., Lazzara, G., Meo, P.L., Riela, S., et al. (2022). 1,2,3-Oligotriazoles modified halloysite nanotubes as potential active biological species: synthesis and characterization. ARKIVOC, 2022(2), 1-9 [10.24820/ark.5550190.p011.685].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/533776
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