By screening faecal samples collected over four consecutive years (2002-2005) from hospitalized children with diarrhoea in Palermo, Italy, astroviruses (HAstVs) were detected in 3.95% of the patients. The predominant type circulating was HAstV-1 but, in 2002, only HAstV-2 and -4 were identified. Interestingly, the HAstVs-2 detected appeared to be consistently different in 5' end of their open reading frame 2 from the previously described subtypes. These novel type 2 strains were included in a new 2c lineage based on the phylogenetic analysis and the presence of nine peculiar substitutions.
De Grazia, S., Platia, M.A., Rotolo, V., Colomba, C., Martella, V., Giammanco, G. (2011). Surveillance of human astrovirus circulation in Italy 2002-2005: emergence of lineage 2c strains. CLINICAL MICROBIOLOGY AND INFECTION, 17(1), 97-101 [10.1111/j.1469-0691.2010.03207.x].
Surveillance of human astrovirus circulation in Italy 2002-2005: emergence of lineage 2c strains
DE GRAZIA, Simona;PLATIA, Maria Angela;COLOMBA, Claudia;GIAMMANCO, Giovanni
2011-01-01
Abstract
By screening faecal samples collected over four consecutive years (2002-2005) from hospitalized children with diarrhoea in Palermo, Italy, astroviruses (HAstVs) were detected in 3.95% of the patients. The predominant type circulating was HAstV-1 but, in 2002, only HAstV-2 and -4 were identified. Interestingly, the HAstVs-2 detected appeared to be consistently different in 5' end of their open reading frame 2 from the previously described subtypes. These novel type 2 strains were included in a new 2c lineage based on the phylogenetic analysis and the presence of nine peculiar substitutions.
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