In this work, with the aim to obtain a wound dressing hydrogel, an amine derivative of gellan gum was crosslinked in the presence of 4arm-polyethylenglycole-vinylsulfone. Through this easy and reproducible chemical procedure, a hydrogel with advanced elastic properties and hydrolytic resistance under physiological conditions was obtained. The incorporation of different quantities of polydopamine in the gelling solutions allows to obtain different hydrogels with marked photothermal properties when irradiated with a laser in the near infrared at 810 nm. The organic nanoparticles, reacting with the amino groups of the polysaccharide derivative, contribute to increase the storage moduli of the hydrogels. Ciprofloxacin was loaded into the hydrogel with higher amount of polydopamine and drug delivery experiments were performed to investigate the effect of irradiation on the antibiotic release profile. Antimicrobial studies, evaluated against S. aureus and P. aeruginosa, revealed that generated hyperthermia exerts a direct inhibition on the pathogens growth and, in the case of S. aureus, adjuvates the ciprofloxacin antimicrobial effect.

Fiorica C., Palumbo F.S., Pitarresi G., Biscari G., Martorana A., Calà C., et al. (2021). Ciprofloxacin releasing gellan gum/polydopamine based hydrogels with near infrared activated photothermal properties. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 610, 1-9 [10.1016/j.ijpharm.2021.121231].

Ciprofloxacin releasing gellan gum/polydopamine based hydrogels with near infrared activated photothermal properties

Fiorica C.
Primo
;
Palumbo F. S.
Secondo
;
Pitarresi G.
;
Biscari G.;Martorana A.;Maida C. M.
Penultimo
;
Giammona G.
Ultimo
2021

Abstract

In this work, with the aim to obtain a wound dressing hydrogel, an amine derivative of gellan gum was crosslinked in the presence of 4arm-polyethylenglycole-vinylsulfone. Through this easy and reproducible chemical procedure, a hydrogel with advanced elastic properties and hydrolytic resistance under physiological conditions was obtained. The incorporation of different quantities of polydopamine in the gelling solutions allows to obtain different hydrogels with marked photothermal properties when irradiated with a laser in the near infrared at 810 nm. The organic nanoparticles, reacting with the amino groups of the polysaccharide derivative, contribute to increase the storage moduli of the hydrogels. Ciprofloxacin was loaded into the hydrogel with higher amount of polydopamine and drug delivery experiments were performed to investigate the effect of irradiation on the antibiotic release profile. Antimicrobial studies, evaluated against S. aureus and P. aeruginosa, revealed that generated hyperthermia exerts a direct inhibition on the pathogens growth and, in the case of S. aureus, adjuvates the ciprofloxacin antimicrobial effect.
Settore CHIM/09 - Farmaceutico Tecnologico Applicativo
https://www.sciencedirect.com/science/article/pii/S0378517321010371?via=ihub
Fiorica C., Palumbo F.S., Pitarresi G., Biscari G., Martorana A., Calà C., et al. (2021). Ciprofloxacin releasing gellan gum/polydopamine based hydrogels with near infrared activated photothermal properties. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 610, 1-9 [10.1016/j.ijpharm.2021.121231].
File in questo prodotto:
File Dimensione Formato  
2021 Int J Pharm.pdf

Solo gestori archvio

Descrizione: Articolo
Tipologia: Versione Editoriale
Dimensione 4.71 MB
Formato Adobe PDF
4.71 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/524458
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 4
  • ???jsp.display-item.citation.isi??? ND
social impact