Leucocyte telomere length (LTL) shortening is a marker of cellular senescence and associates with increased risk of cardiovascular disease (CVD). A number of cardiovascular risk factors affect LTL, but the correlation between elevated LDL cholesterol (LDL-C) and shorter LTL is debated: in small cohorts including subjects with a clinical diagnosis of familial hypercholesterolaemia (FH). We assessed the relationship between LDL-C and LTL in subjects with genetic familial hypercholesterolaemia (HeFH) compared to those with clinically diagnosed, but not genetically confirmed FH (CD-FH), and normocholesterolaemic subjects.

Baragetti, A., Bonacina, F., Da Dalt, L., Moregola, A., Zampoleri, V., Pellegatta, F., et al. (2020). Genetically determined hypercholesterolaemia results into premature leucocyte telomere length shortening and reduced haematopoietic precursors. EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 29(5), 721-729 [10.1093/eurjpc/zwaa115].

Genetically determined hypercholesterolaemia results into premature leucocyte telomere length shortening and reduced haematopoietic precursors

Spina, Rossella;Cefalù', Angelo Baldassare;Averna, Maurizio;
2020-05-05

Abstract

Leucocyte telomere length (LTL) shortening is a marker of cellular senescence and associates with increased risk of cardiovascular disease (CVD). A number of cardiovascular risk factors affect LTL, but the correlation between elevated LDL cholesterol (LDL-C) and shorter LTL is debated: in small cohorts including subjects with a clinical diagnosis of familial hypercholesterolaemia (FH). We assessed the relationship between LDL-C and LTL in subjects with genetic familial hypercholesterolaemia (HeFH) compared to those with clinically diagnosed, but not genetically confirmed FH (CD-FH), and normocholesterolaemic subjects.
Settore MED/09 - Medicina Interna
Baragetti, A., Bonacina, F., Da Dalt, L., Moregola, A., Zampoleri, V., Pellegatta, F., et al. (2020). Genetically determined hypercholesterolaemia results into premature leucocyte telomere length shortening and reduced haematopoietic precursors. EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY, 29(5), 721-729 [10.1093/eurjpc/zwaa115].
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10447/522500
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