Long-term anti-tumour necrosis factor therapy reverses the progression of carotid intima-media thickness in female patients with active rheumatoid arthritis

Ferrante, A; Giardina, A; Ciccia, F; Parrinello, G; Licata, G; Avellone, G; Giardina, E; Impastato, R; Triolo, G

doi:10.1007/s00296-009-0935-2

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The objective of the study is to evaluate the effect of TNF inhibition on carotid thickness over a 2-year period. 144 women with RA diagnosed according to ACR criteria, without clinical evidence of cardiac and/or vascular disease were enrolled and compared with 78 matched controls. All patients received methotrexate (15–20 mg weekly) for 3 months. Responders (n = 79) continued to be treated with methotrexate, non-responders (n = 40) moved to methotrexate plus a TNF alpha antagonist. Echosonographic studies of carotids were obtained before and after 2-year follow-up. A significant decrease of ca-IMT was observed in anti-TNF-treated patients (P < 0.001); on the other hand, no significant variation of ca-IMT was observed after 2 years in MTX-treated patients. Our study indicates that anti-TNF blocking agents, but not methotrexate, are capable of reducing IMT of carotid arteries in female RA patients in a 2-year follow-up.

Data di pubblicazione:	2009
Titolo:	Long-term anti-tumour necrosis factor therapy reverses the progression of carotid intima-media thickness in female patients with active rheumatoid arthritis
Autori:	FERRANTE, Angelo GIARDINA, Annarita CICCIA, Francesco PARRINELLO, Gaspare LICATA, Giuseppe AVELLONE, Gino Giardina, E IMPASTATO, Rosalia TRIOLO, Giovanni mostra contributor esterni nascondi contributor esterni
Citazione:	Ferrante, A., Giardina, A., Ciccia, F., Parrinello, G., Licata, G., Avellone, G., et al. (2009). Long-term anti-tumour necrosis factor therapy reverses the progression of carotid intima-media thickness in female patients with active rheumatoid arthritis. RHEUMATOLOGY INTERNATIONAL, 30, 193-198.
Rivista:	RHEUMATOLOGY INTERNATIONAL
Digital Object Identifier (DOI):	http://dx.doi.org/10.1007/s00296-009-0935-2
Abstract:	The objective of the study is to evaluate the effect of TNF inhibition on carotid thickness over a 2-year period. 144 women with RA diagnosed according to ACR criteria, without clinical evidence of cardiac and/or vascular disease were enrolled and compared with 78 matched controls. All patients received methotrexate (15–20 mg weekly) for 3 months. Responders (n = 79) continued to be treated with methotrexate, non-responders (n = 40) moved to methotrexate plus a TNF alpha antagonist. Echosonographic studies of carotids were obtained before and after 2-year follow-up. A significant decrease of ca-IMT was observed in anti-TNF-treated patients (P < 0.001); on the other hand, no significant variation of ca-IMT was observed after 2 years in MTX-treated patients. Our study indicates that anti-TNF blocking agents, but not methotrexate, are capable of reducing IMT of carotid arteries in female RA patients in a 2-year follow-up.
Settore Scientifico Disciplinare:	Settore MED/16 - Reumatologia
Appare nelle tipologie:	1.01 Articolo in rivista

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