Objective: To individuate a novel sex-specific index, based on Waist Circumference (WC), Body Mass Index (BMI), Triglycerides (TG) and HDL cholesterol (HDL), indirectly expressing visceral fat function. Research design and Methods: Visceral Adiposity Index (VAI) was first modelled on 315 non-obese healthy subjects. Using two multiple logistic regression models, VAI was retrospectively validated in 1,498 primary care patients in comparison to classical cardio and cerebrovascular risk factors. Results: All components of metabolic syndrome increased significantly across VAI quintiles. VAI was independently associated with both cardiovascular (OR:2.45; 95%CI: 1.52-3.95; p<0.001) and cerebrovascular events (OR:1.63; 95%CI: 1.06-2.50; p=0.025). VAI also showed significant inverse correlation with insulin sensitivity during euglycemic-hyperinsulinemic clamp in a subgroup of patients (R(s)= -0.721; p<0.001). By contrast, no correlations were found for WC and BMI. Conclusions: Our study suggests VAI is a valuable indicator of "visceral adipose function" and insulin sensitivity, and its increase is strongly associated with cardiometabolic risk.

Amato, M.C., Giordano, C., Galia, M., Criscimanna, A., Vitabile, S., Midiri, M., et al. (2010). Visceral Adiposity Index (VAI): A Reliable Indicator Of Visceral Fat Function Associated With Cardiometabolic Risk. DIABETES CARE, 2010-01.

Visceral Adiposity Index (VAI): A Reliable Indicator Of Visceral Fat Function Associated With Cardiometabolic Risk.

AMATO, Marco Calogero;GIORDANO, Carla;GALIA, Massimo;CRISCIMANNA, Angela;VITABILE, Salvatore;MIDIRI, Massimo;GALLUZZO, Aldo
2010-01-01

Abstract

Objective: To individuate a novel sex-specific index, based on Waist Circumference (WC), Body Mass Index (BMI), Triglycerides (TG) and HDL cholesterol (HDL), indirectly expressing visceral fat function. Research design and Methods: Visceral Adiposity Index (VAI) was first modelled on 315 non-obese healthy subjects. Using two multiple logistic regression models, VAI was retrospectively validated in 1,498 primary care patients in comparison to classical cardio and cerebrovascular risk factors. Results: All components of metabolic syndrome increased significantly across VAI quintiles. VAI was independently associated with both cardiovascular (OR:2.45; 95%CI: 1.52-3.95; p<0.001) and cerebrovascular events (OR:1.63; 95%CI: 1.06-2.50; p=0.025). VAI also showed significant inverse correlation with insulin sensitivity during euglycemic-hyperinsulinemic clamp in a subgroup of patients (R(s)= -0.721; p<0.001). By contrast, no correlations were found for WC and BMI. Conclusions: Our study suggests VAI is a valuable indicator of "visceral adipose function" and insulin sensitivity, and its increase is strongly associated with cardiometabolic risk.
2010
Amato, M.C., Giordano, C., Galia, M., Criscimanna, A., Vitabile, S., Midiri, M., et al. (2010). Visceral Adiposity Index (VAI): A Reliable Indicator Of Visceral Fat Function Associated With Cardiometabolic Risk. DIABETES CARE, 2010-01.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/46943
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1099
  • ???jsp.display-item.citation.isi??? 985
social impact