Derivatives of the new ring system pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate as DNA intercalating agents.
LAURIA, A., ABBATE, I., PATELLA, C., GAMBINO, N., SILVESTRI, A., BARONE, G., et al. (2008). Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement. TETRAHEDRON LETTERS, 49(35), 5125-5128 [10.1016/j.tetlet.2008.06.104].
Pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine: a new ring system through Dimroth rearrangement
LAURIA, Antonino;ABBATE, Ilenia;PATELLA, Chiara;GAMBINO, Noemi;SILVESTRI, Arturo;BARONE, Giampaolo;ALMERICO, Anna Maria
2008-01-01
Abstract
Derivatives of the new ring system pyrazolo[3,4-d][1,2,3]triazolo[1,5-a]pyrimidine were synthesized from the corresponding angular isomers, through a Dimroth rearrangement, in quantitative yields. Preliminary computational studies demonstrated that this class of compounds could be a good candidate as DNA intercalating agents.
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