This review deals with 1,5-diheterocines that exhibited biological properties and covers comprehensively the literature from 2007 to the end of February 2019. Among the six possible heterocyclic systems belonging to the eight-membered rings with two heteroatoms, N, O, and S, five had derivatives showing pharmacological activities: 1,5-diazocines, 1,5-oxazocines, 1,5-thiazocines, 1,5-dioxocins, and 1,5-dithiocins. Instead, literature reported no articles dealing with 1,5-oxathiocins of interest in medicinal chemistry. In addition to uncondensed derivatives, 1,5-diheterocines fused to five- and six-membered carbocycles or heterocycles are covered. Bridged 1,5-diheterocines are covered as well.

Parrino B., Cascioferro S., Carbone D., Cirrincione G., Diana P. (2020). Eight-membered heterocycles with two heteroatoms in a 1,5-relationship of interest in medicinal chemistry. In Advances in Heterocyclic Chemistry (pp. 135-239). Academic Press Inc. [10.1016/bs.aihch.2019.11.004].

Eight-membered heterocycles with two heteroatoms in a 1,5-relationship of interest in medicinal chemistry

Parrino B.;Cascioferro S.;Carbone D.;Cirrincione G.;Diana P.
2020-01-01

Abstract

This review deals with 1,5-diheterocines that exhibited biological properties and covers comprehensively the literature from 2007 to the end of February 2019. Among the six possible heterocyclic systems belonging to the eight-membered rings with two heteroatoms, N, O, and S, five had derivatives showing pharmacological activities: 1,5-diazocines, 1,5-oxazocines, 1,5-thiazocines, 1,5-dioxocins, and 1,5-dithiocins. Instead, literature reported no articles dealing with 1,5-oxathiocins of interest in medicinal chemistry. In addition to uncondensed derivatives, 1,5-diheterocines fused to five- and six-membered carbocycles or heterocycles are covered. Bridged 1,5-diheterocines are covered as well.
Parrino B., Cascioferro S., Carbone D., Cirrincione G., Diana P. (2020). Eight-membered heterocycles with two heteroatoms in a 1,5-relationship of interest in medicinal chemistry. In Advances in Heterocyclic Chemistry (pp. 135-239). Academic Press Inc. [10.1016/bs.aihch.2019.11.004].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/414878
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