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EnglishThis review deals with 1,5-diheterocines that exhibited biological properties and covers comprehensively the literature from 2007 to the end of February 2019. Among the six possible heterocyclic systems belonging to the eight-membered rings with two heteroatoms, N, O, and S, five had derivatives showing pharmacological activities: 1,5-diazocines, 1,5-oxazocines, 1,5-thiazocines, 1,5-dioxocins, and 1,5-dithiocins. Instead, literature reported no articles dealing with 1,5-oxathiocins of interest in medicinal chemistry. In addition to uncondensed derivatives, 1,5-diheterocines fused to five- and six-membered carbocycles or heterocycles are covered. Bridged 1,5-diheterocines are covered as well.
Parrino B., Cascioferro S., Carbone D., Cirrincione G., & Diana P. (2020). Eight-membered heterocycles with two heteroatoms in a 1,5-relationship of interest in medicinal chemistry. In Advances in Heterocyclic Chemistry (pp. 135-239). Academic Press Inc. [10.1016/bs.aihch.2019.11.004].
| Data di pubblicazione: | 2020 | |
| Titolo: | Eight-membered heterocycles with two heteroatoms in a 1,5-relationship of interest in medicinal chemistry | |
| Autori: | DIANA, Patrizia (Corresponding) | |
| Citazione: | Parrino B., Cascioferro S., Carbone D., Cirrincione G., & Diana P. (2020). Eight-membered heterocycles with two heteroatoms in a 1,5-relationship of interest in medicinal chemistry. In Advances in Heterocyclic Chemistry (pp. 135-239). Academic Press Inc. [10.1016/bs.aihch.2019.11.004]. | |
| Abstract: | This review deals with 1,5-diheterocines that exhibited biological properties and covers comprehensively the literature from 2007 to the end of February 2019. Among the six possible heterocyclic systems belonging to the eight-membered rings with two heteroatoms, N, O, and S, five had derivatives showing pharmacological activities: 1,5-diazocines, 1,5-oxazocines, 1,5-thiazocines, 1,5-dioxocins, and 1,5-dithiocins. Instead, literature reported no articles dealing with 1,5-oxathiocins of interest in medicinal chemistry. In addition to uncondensed derivatives, 1,5-diheterocines fused to five- and six-membered carbocycles or heterocycles are covered. Bridged 1,5-diheterocines are covered as well. | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/bs.aihch.2019.11.004 | |
| Appare nelle tipologie: | 2.01 Capitolo o Saggio |
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