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EnglishBackground: Dyslipidaemias is a recognized risk factor for atherosclerosis, however, new evidence brought to light by trials investigating therapies to enhance HDL-cholesterol have suggested an increased atherosclerotic risk when HDL-C is high. Results: Several studies highlight the central role in atherosclerotic disease of dysfunctional lipoproteins; oxidised LDL-cholesterol is an important feature, according to “oxidation hy-pothesis”, of atherosclerotic lesion, however, there is today a growing interest for dysfunctional HDL-cholesterol. The target of our paper is to review the functions of modified and dysfunctional lipoproteins in atherogenesis. Conclusion: Taking into account the central role recognized to dysfunctional lipoproteins, measurements of functional features of lipoproteins, instead of conventional routine serum evaluation of lipoproteins, could offer a valid contribution in experimental studies as in clinical practice to stratify atherosclerotic risk.
Arnao V., Tuttolomondo A., Daidone M., & Pinto A. (2019). Lipoproteins in atherosclerosis process. CURRENT MEDICINAL CHEMISTRY, 26(9), 1525-1543.
| Data di pubblicazione: | 2019 | |
| Titolo: | Lipoproteins in atherosclerosis process | |
| Autori: | PINTO, Antonio [Supervision] | |
| Citazione: | Arnao V., Tuttolomondo A., Daidone M., & Pinto A. (2019). Lipoproteins in atherosclerosis process. CURRENT MEDICINAL CHEMISTRY, 26(9), 1525-1543. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.2174/0929867326666190516103953 | |
| Abstract: | Background: Dyslipidaemias is a recognized risk factor for atherosclerosis, however, new evidence brought to light by trials investigating therapies to enhance HDL-cholesterol have suggested an increased atherosclerotic risk when HDL-C is high. Results: Several studies highlight the central role in atherosclerotic disease of dysfunctional lipoproteins; oxidised LDL-cholesterol is an important feature, according to “oxidation hy-pothesis”, of atherosclerotic lesion, however, there is today a growing interest for dysfunctional HDL-cholesterol. The target of our paper is to review the functions of modified and dysfunctional lipoproteins in atherogenesis. Conclusion: Taking into account the central role recognized to dysfunctional lipoproteins, measurements of functional features of lipoproteins, instead of conventional routine serum evaluation of lipoproteins, could offer a valid contribution in experimental studies as in clinical practice to stratify atherosclerotic risk. | |
| URL: | http://www.eurekaselect.com/172162 | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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