Background: Dyslipidaemias is a recognized risk factor for atherosclerosis, however, new evidence brought to light by trials investigating therapies to enhance HDL-cholesterol have suggested an increased atherosclerotic risk when HDL-C is high. Results: Several studies highlight the central role in atherosclerotic disease of dysfunctional lipoproteins; oxidised LDL-cholesterol is an important feature, according to “oxidation hy-pothesis”, of atherosclerotic lesion, however, there is today a growing interest for dysfunctional HDL-cholesterol. The target of our paper is to review the functions of modified and dysfunctional lipoproteins in atherogenesis. Conclusion: Taking into account the central role recognized to dysfunctional lipoproteins, measurements of functional features of lipoproteins, instead of conventional routine serum evaluation of lipoproteins, could offer a valid contribution in experimental studies as in clinical practice to stratify atherosclerotic risk.

Arnao V., Tuttolomondo A., Daidone M., Pinto A. (2019). Lipoproteins in atherosclerosis process. CURRENT MEDICINAL CHEMISTRY, 26(9), 1525-1543 [10.2174/0929867326666190516103953].

Lipoproteins in atherosclerosis process

Arnao V.
Writing – Original Draft Preparation
;
Tuttolomondo A.
Conceptualization
;
Daidone M.
Writing – Review & Editing
;
Pinto A.
Supervision
2019-01-01

Abstract

Background: Dyslipidaemias is a recognized risk factor for atherosclerosis, however, new evidence brought to light by trials investigating therapies to enhance HDL-cholesterol have suggested an increased atherosclerotic risk when HDL-C is high. Results: Several studies highlight the central role in atherosclerotic disease of dysfunctional lipoproteins; oxidised LDL-cholesterol is an important feature, according to “oxidation hy-pothesis”, of atherosclerotic lesion, however, there is today a growing interest for dysfunctional HDL-cholesterol. The target of our paper is to review the functions of modified and dysfunctional lipoproteins in atherogenesis. Conclusion: Taking into account the central role recognized to dysfunctional lipoproteins, measurements of functional features of lipoproteins, instead of conventional routine serum evaluation of lipoproteins, could offer a valid contribution in experimental studies as in clinical practice to stratify atherosclerotic risk.
http://www.eurekaselect.com/172162
Arnao V., Tuttolomondo A., Daidone M., Pinto A. (2019). Lipoproteins in atherosclerosis process. CURRENT MEDICINAL CHEMISTRY, 26(9), 1525-1543 [10.2174/0929867326666190516103953].
File in questo prodotto:
File Dimensione Formato  
Tuttolomondo Lipoproteins.pdf

Solo gestori archvio

Tipologia: Versione Editoriale
Dimensione 8.76 MB
Formato Adobe PDF
8.76 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/401980
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 10
social impact