Megalencephaly and macrocephaly present with a head circumference measurement 2 standard deviations above the age-related mean. However, even if pathologic events resulting in both megalencephaly and macrocephaly may coexist, a distinction between these two entities is appropriate, as they represent clinical expression of different disorders with a different approach in clinical work-up, overall prognosis, and treatment. Megalencephaly defines an increased growth of cerebral structures related to dysfunctional anomalies during the various steps of brain development in the neuronal proliferation and/or migration phases or as a consequence of postnatal abnormal events. The disorders associated with megalencephaly are classically defined into 3 groups: idiopathic or benign, metabolic, and anatomic. In this article, we seek to underline the clinical aspect of megalencephaly, emphasizing the main disorders that manifest with this anomaly in an attempt to properly categorize these disorders within the megalencephaly group.

Pavone P, P.A. (2017). A clinical review on megalencephaly: A large brain as a possible sign of cerebral impairment. MEDICINE, 96(26) [10.1097/MD.0000000000006814].

A clinical review on megalencephaly: A large brain as a possible sign of cerebral impairment.

Corsello G;Falsaperla R
2017-01-01

Abstract

Megalencephaly and macrocephaly present with a head circumference measurement 2 standard deviations above the age-related mean. However, even if pathologic events resulting in both megalencephaly and macrocephaly may coexist, a distinction between these two entities is appropriate, as they represent clinical expression of different disorders with a different approach in clinical work-up, overall prognosis, and treatment. Megalencephaly defines an increased growth of cerebral structures related to dysfunctional anomalies during the various steps of brain development in the neuronal proliferation and/or migration phases or as a consequence of postnatal abnormal events. The disorders associated with megalencephaly are classically defined into 3 groups: idiopathic or benign, metabolic, and anatomic. In this article, we seek to underline the clinical aspect of megalencephaly, emphasizing the main disorders that manifest with this anomaly in an attempt to properly categorize these disorders within the megalencephaly group.
2017
Pavone P, P.A. (2017). A clinical review on megalencephaly: A large brain as a possible sign of cerebral impairment. MEDICINE, 96(26) [10.1097/MD.0000000000006814].
File in questo prodotto:
File Dimensione Formato  
Pavone_A clinical review on megalencephaly_2017.pdf

accesso aperto

Tipologia: Versione Editoriale
Dimensione 326.63 kB
Formato Adobe PDF
326.63 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/393792
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 51
  • ???jsp.display-item.citation.isi??? 48
social impact