OBJECTIVE: Persistent villous atrophy in patients with celiac disease (CD) on a gluten-free diet (GFD) is reported with increasing frequency. The aim of this study was to evaluate a possible association between persistent damage of the villi and "atypical" gastrointestinal symptoms in CD patients on a GFD. MATERIAL AND METHODS: Sixty-nine CD patients on a GFD were divided into two groups: Group A included 42 patients (6 M, 36 F, age range 17-62 years) undergoing esophagogastroduodenoscopies (EGDs) due to the presence of symptoms; Group B included 27 control patients (6 M, 21 F, age range 24-71 years) who were asymptomatic at the time of the study. Both groups underwent EGDs and a duodenal histologic study. RESULTS: Persistent endoscopic lesions were more frequent in Group A (30/42) than in Group B (12/27; p=0.01). Villous atrophy was significantly more frequent in Group A than in Group B: 85% versus 33% (p<0.0001; odds ratio (OR)=12; 95% CI 3.7-38.9). Gastrointestinal symptoms in the Group A patients were different from those present at CD diagnosis: anemia/diarrhea/weight loss in 6 cases; gastroesophageal reflux disease (GERD)-like symptoms in 12 cases; abdominal pain/constipation in 24 cases. In Group A there was no difference in gender distribution, age and duration of GFD between subjects with normal villi and those with persistent partial villous atrophy. Patients with persistent symptoms showed a higher intraepithelial eosinophil count (p=0.005) than the asymptomatic patients (p=0.01). CONCLUSIONS: Persistent intestinal villous atrophy in CD patients on a GFD is associated with gastrointestinal symptoms considered "atypical" for CD and not present at CD diagnosis.
Carroccio, A., Ambrosiano, G., DI PRIMA, L., Pirrone, G., Iacono, G., Florena, A., et al. (2008). Clinical symptoms in celiac patients on a gluten-free diet. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 43(11), 1315-1321.
|Data di pubblicazione:||2008|
|Titolo:||Clinical symptoms in celiac patients on a gluten-free diet.|
|Citazione:||Carroccio, A., Ambrosiano, G., DI PRIMA, L., Pirrone, G., Iacono, G., Florena, A., et al. (2008). Clinical symptoms in celiac patients on a gluten-free diet. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 43(11), 1315-1321.|
|Appare nelle tipologie:||1.01 Articolo in rivista|