Background: One of the most important vulnerabilities falling the efficacy of recombinant human growth hormone (r-hGH) treatment is low adherence especially in young patients. This study was planned to describe the correlation between r-hGH treatment efficacy and adherence in real-life setting using easypod™. Methods: Forty patients younger than 18 years, affected by a clinical condition in which r-hGH is available and treated with r-hGH easypod™, were enrolled in a retrospective, observational, real-world data, monocentric trial. The study design provided the retrospective collection of records collected by a questionnaire proposed to the patients and their parents and compared with registered data by the new generation electronic device r-hGH easypod™. Number of injections and doses were collected and used to assess the percentage of administered GH doses to measure treatment adherence. The r-hGH treatment efficacy was evaluated comparing standard deviation score for height (SDS) between baseline and follow-up visit, according to clinical practice. Results: The mean treatment adherence was 92.20% and it was inversely related to patients' age (R = - 0.358, p = 0.023), and significantly higher in the sub-group of patients with age between 10 and 13 years. Treatment adherence showed an inverse correlation with the years of therapy (R = - 0.453, p = 0.003) and with the number of r-hGH administrations (R = - 0.392, p = 0.012). However, the height increase did not reach a significant correlation with treatment adherence (R = - 0.067, p = 0.683). Conclusions: Children and adolescent patients with GH deficiency due to different clinical conditions show high adherence to r-hGH treatment tested by easypod™. Easypod™ could be used as an important device to control patients' adherence in daily treatment for chronic diseases with expensive drugs.

Maggio, M.C., Vergara, B., Porcelli, P., Corsello, G. (2018). Improvement of treatment adherence with growth hormone by easypod™ device: Experience of an Italian centre. THE ITALIAN JOURNAL OF PEDIATRICS, 44, 1-8 [10.1186/s13052-018-0548-z].

Improvement of treatment adherence with growth hormone by easypod™ device: Experience of an Italian centre

Maggio, Maria Cristina
;
Vergara, Beatrice;Corsello, Giovanni
2018-01-01

Abstract

Background: One of the most important vulnerabilities falling the efficacy of recombinant human growth hormone (r-hGH) treatment is low adherence especially in young patients. This study was planned to describe the correlation between r-hGH treatment efficacy and adherence in real-life setting using easypod™. Methods: Forty patients younger than 18 years, affected by a clinical condition in which r-hGH is available and treated with r-hGH easypod™, were enrolled in a retrospective, observational, real-world data, monocentric trial. The study design provided the retrospective collection of records collected by a questionnaire proposed to the patients and their parents and compared with registered data by the new generation electronic device r-hGH easypod™. Number of injections and doses were collected and used to assess the percentage of administered GH doses to measure treatment adherence. The r-hGH treatment efficacy was evaluated comparing standard deviation score for height (SDS) between baseline and follow-up visit, according to clinical practice. Results: The mean treatment adherence was 92.20% and it was inversely related to patients' age (R = - 0.358, p = 0.023), and significantly higher in the sub-group of patients with age between 10 and 13 years. Treatment adherence showed an inverse correlation with the years of therapy (R = - 0.453, p = 0.003) and with the number of r-hGH administrations (R = - 0.392, p = 0.012). However, the height increase did not reach a significant correlation with treatment adherence (R = - 0.067, p = 0.683). Conclusions: Children and adolescent patients with GH deficiency due to different clinical conditions show high adherence to r-hGH treatment tested by easypod™. Easypod™ could be used as an important device to control patients' adherence in daily treatment for chronic diseases with expensive drugs.
2018
Maggio, M.C., Vergara, B., Porcelli, P., Corsello, G. (2018). Improvement of treatment adherence with growth hormone by easypod™ device: Experience of an Italian centre. THE ITALIAN JOURNAL OF PEDIATRICS, 44, 1-8 [10.1186/s13052-018-0548-z].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/356565
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