The great therapeutical success achieved by oncology is counterbalanced by growing evidences of cardiovascular (CV) toxicity due to many antineoplastic treatments. Cardiac adverse events may cause premature discontinuation of effective oncologic treatments or occur as late events undermining the oncologic success. Arterial hypertension is both the most common comorbidity in cancer patients and a frequent adverse effect of anticancer therapies. A pre-existing hypertension is known to increase the risk of other cardiac adverse events due to oncologic treatments, in particular heart failure. Moreover, as a strict association between cancer and CV diseases has emerged over the recent years, various analyses have shown a direct relationship between hypertension and cancer incidence and mortality. Finally, many antineoplastic treatments may cause a rise in blood pressure (BP) values, particularly the novel anti VEGF agents, this possibly compromising efficacy of chemotherapy. Aim of this review is to revise the topic and the many aspects linking arterial hypertension and cancer, and to provide a comprehensive and practical guide of the current treatment approaches.

Tini, G., Sarocchi, M., Tocci, G., Arboscello, E., Ghigliotti, G., Novo, G., et al. (2019). Arterial hypertension in cancer: The elephant in the room. INTERNATIONAL JOURNAL OF CARDIOLOGY, 281, 133-139 [10.1016/j.ijcard.2019.01.082].

Arterial hypertension in cancer: The elephant in the room

Novo, Giuseppina;
2019-01-01

Abstract

The great therapeutical success achieved by oncology is counterbalanced by growing evidences of cardiovascular (CV) toxicity due to many antineoplastic treatments. Cardiac adverse events may cause premature discontinuation of effective oncologic treatments or occur as late events undermining the oncologic success. Arterial hypertension is both the most common comorbidity in cancer patients and a frequent adverse effect of anticancer therapies. A pre-existing hypertension is known to increase the risk of other cardiac adverse events due to oncologic treatments, in particular heart failure. Moreover, as a strict association between cancer and CV diseases has emerged over the recent years, various analyses have shown a direct relationship between hypertension and cancer incidence and mortality. Finally, many antineoplastic treatments may cause a rise in blood pressure (BP) values, particularly the novel anti VEGF agents, this possibly compromising efficacy of chemotherapy. Aim of this review is to revise the topic and the many aspects linking arterial hypertension and cancer, and to provide a comprehensive and practical guide of the current treatment approaches.
2019
Tini, G., Sarocchi, M., Tocci, G., Arboscello, E., Ghigliotti, G., Novo, G., et al. (2019). Arterial hypertension in cancer: The elephant in the room. INTERNATIONAL JOURNAL OF CARDIOLOGY, 281, 133-139 [10.1016/j.ijcard.2019.01.082].
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0167527318355682-main.pdf

Solo gestori archvio

Tipologia: Versione Editoriale
Dimensione 506.3 kB
Formato Adobe PDF
506.3 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/354558
Citazioni
  • ???jsp.display-item.citation.pmc??? 21
  • Scopus 50
  • ???jsp.display-item.citation.isi??? 39
social impact