The neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase.
KOCH G, BRUSA L, CALTAGIRONE C, PEPPE A, OLIVERI M, STANZIONE P, et al. (2005). rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease. NEUROLOGY, 65(4), 623-625 [10.1212/01.wnl.0000172861.36430.95].
rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease
OLIVERI, Massimiliano;
2005-01-01
Abstract
The neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
