Halloysite-cyclodextrin hybrid was employed as carrier for sustained release of clotrimazole for vaginal or buccal treatment of Candidiasis. The nanocarrier was obtained by functionalization of halloysite surface with cyclodextrin moieties by means of microwave irradiation, with the final goal to obtain a scaffold for the covalent linkage of cysteamine hydrochloride. The interaction between clotrimazole and the pristine components, namely cyclodextrin and halloysite, was thoroughly investigated by several techniques such as DSC, TGA, UV–vis spectroscopy and some adsorption studies were, also, carried out. The release of the antifungine molecule was finally investigated in a medium that imitates the physiological conditions.

Marina Massaro, A.C. (2018). Functionalized halloysite nanotubes: Efficient carrier systems for antifungine drugs. APPLIED CLAY SCIENCE, 160, 186-192 [10.1016/j.clay.2018.01.005].

Functionalized halloysite nanotubes: Efficient carrier systems for antifungine drugs

Marina Massaro;Carmelo Giuseppe Colletti⁠;Giuseppe Lazzara⁠;Renato Noto⁠;Serena Riela⁠
2018-01-01

Abstract

Halloysite-cyclodextrin hybrid was employed as carrier for sustained release of clotrimazole for vaginal or buccal treatment of Candidiasis. The nanocarrier was obtained by functionalization of halloysite surface with cyclodextrin moieties by means of microwave irradiation, with the final goal to obtain a scaffold for the covalent linkage of cysteamine hydrochloride. The interaction between clotrimazole and the pristine components, namely cyclodextrin and halloysite, was thoroughly investigated by several techniques such as DSC, TGA, UV–vis spectroscopy and some adsorption studies were, also, carried out. The release of the antifungine molecule was finally investigated in a medium that imitates the physiological conditions.
2018
Settore CHIM/06 - Chimica Organica
Settore CHIM/02 - Chimica Fisica
Marina Massaro, A.C. (2018). Functionalized halloysite nanotubes: Efficient carrier systems for antifungine drugs. APPLIED CLAY SCIENCE, 160, 186-192 [10.1016/j.clay.2018.01.005].
File in questo prodotto:
File Dimensione Formato  
functionalized_2018.pdf

Solo gestori archvio

Descrizione: Articolo in volume
Tipologia: Versione Editoriale
Dimensione 886.93 kB
Formato Adobe PDF
886.93 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/286244
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 48
  • ???jsp.display-item.citation.isi??? 40
social impact