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EnglishDeveloping new treatment strategies for acute ischemic stroke in the last twenty years has offered some important successes, but also several failures. Most trials of neuroprotective therapies have been uniformly negative to date. Recent research has reported how excitatory amino acids act as the major excitatory neurotransmitters in the cerebral cortex and hippocampus. Furthermore, other therapeutic targets such as free radical scavenger strategies and the anti-inflammatory neuroprotective strategy have been evaluated with conflicting data in animal models and human subjects with acute ischemic stroke. Whereas promising combinations of neuroprotection and neurorecovery, such as citicoline, albumin and cerebrolysin have been tested with findings worthy of further evaluation in larger randomized clinical trials. Understanding the complexities of the ischemic cascade is essential to developing pharmacological targets for acute ischemic stroke in neuroprotective or flow restoration therapeutic strategies
Tuttolomondo, A., Pecoraro, R., Arnao, V., Maugeri, R., Iacopino, D., & Pinto, A. (2015). Developing drug strategies for the neuroprotective treatment of acute ischemic stroke. EXPERT REVIEW OF NEUROTHERAPEUTICS, 15(11), 1271-1284 [10.1586/14737175.2015.1101345].
| Data di pubblicazione: | 2015 | |
| Titolo: | Developing drug strategies for the neuroprotective treatment of acute ischemic stroke. | |
| Autori: | ||
| Citazione: | Tuttolomondo, A., Pecoraro, R., Arnao, V., Maugeri, R., Iacopino, D., & Pinto, A. (2015). Developing drug strategies for the neuroprotective treatment of acute ischemic stroke. EXPERT REVIEW OF NEUROTHERAPEUTICS, 15(11), 1271-1284 [10.1586/14737175.2015.1101345]. | |
| Rivista: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1586/14737175.2015.1101345 | |
| Abstract: | Developing new treatment strategies for acute ischemic stroke in the last twenty years has offered some important successes, but also several failures. Most trials of neuroprotective therapies have been uniformly negative to date. Recent research has reported how excitatory amino acids act as the major excitatory neurotransmitters in the cerebral cortex and hippocampus. Furthermore, other therapeutic targets such as free radical scavenger strategies and the anti-inflammatory neuroprotective strategy have been evaluated with conflicting data in animal models and human subjects with acute ischemic stroke. Whereas promising combinations of neuroprotection and neurorecovery, such as citicoline, albumin and cerebrolysin have been tested with findings worthy of further evaluation in larger randomized clinical trials. Understanding the complexities of the ischemic cascade is essential to developing pharmacological targets for acute ischemic stroke in neuroprotective or flow restoration therapeutic strategies | |
| Settore Scientifico Disciplinare: | Settore MED/09 - Medicina Interna | |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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| Expert Review of Neurotherapeutics Tuttolomondo ottobre 2015.pdf | Expert Rev Neurother. 2015 | N/A | Administrator Richiedi una copia |
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